Shanghai Institute of Nutrition and Health

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

GPR87 protects UVB-damaged skin by coordinating antioxidant, DNA repair, and anti-inflammatory responses via Nrf2 and PI3K/AKT-NF-κB pathways.

data further showed that GPR87 deficiency aggravated inflammatory responses and cyclobutane pyrimidine dimer (CPD) accumulation while attenuating apoptosis in skin cells. Moreover, GPR87 facilitated CPD clearance by regulating the expression and ubiquitination of XPC, a key compo...

Powering the liver toxicity assessment in the organoid era

Hepatotoxicity assessment is paramount in drug development and food safety. Traditional in vitro models suffer from insufficient physiological relevance and poor functional reproducibility. Liver organoids have rapidly emerged as three-dimensional culture models capable of recapi...

An East Asian blood eQTL meta-analysis highlights ancestry-matched eQTL resources for complex-trait genetics

Abstract Expression quantitative trait loci (eQTLs) link genetic variation to gene regulation and complex traits, yet population-scale blood eQTL resources remain limited in East Asian populations. We mapped cis-eQTLs in 1,005 Chinese individuals and meta-analysed them with a Jap...

Acute Kidney Injury During Vancomycin Treatment in Adult Patients With Haematologic Malignancies: A Multicentre Retrospective Study

ABSTRACT Background Acute kidney injury (AKI) during vancomycin treatment remains a rare occurrence in adult patients with haematological malignancies (HMs). The objective of this multicentre study was to investigate the incidence and risk factors for AKI during vancomycin treatm...

Sensitivity Study of the Reactivity-Equivalent Physical Transformation Method for Fluoride Salt Coolant Pebble Bed Reactor Lattice

Conventional dispersed-particle fuel systems, such as TRISO fuel, exhibit typical double heterogeneity. The Reactivity-equivalent Physical Transformation (RPT) method can convert a double-heterogeneity system into a single-heterogeneity system by simplified geometric modelling. I...

Skeletal muscle H3K18 lactylation inhibits hepatic gluconeogenesis through IL-6 mediated interorgan communication

The mechanisms underlying the dynamic interplay between skeletal muscle and systemic glucose homeostasis in type 2 diabetes remain elusive. Increased lactate level has long been noticed in diabetes, however, whether the elevated lactate is a cause or consequence of impaired gluco...