Institution
Shanghai Institute of Materia Medica
Recent research
- Health & MedicineOpen access
Obesity has become a major global public health challenge, and its rising prevalence contributes to substantial health and economic burdens. Existing systematic reviews are largely confined to a single intervention category or to mixed populations, which limits targeted recommend...
- BiologyOpen access
Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...
- Biology
Fungal Phosphatase-Dependent Induction of Host Cell Pyroptosis by Candidalysin
Abstract Fungal infections pose a major public health threat and can cause host cell damage through diverse forms of regulated cell death. However, our understanding of how fungal pathogens interact with host to elicit pyroptosis remains in its infancy. Here, we show that candida...
- Health & MedicineOpen access
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...
- Health & Medicine
ABSTRACT Background and Aim Practical implementation of integrated chemical–biological quality control in Traditional Chinese Medicine (TCM) remains challenging. This study used Salvia miltiorrhiza as a model to develop an exploratory integrated quality‐evaluation strategy that c...
- Health & MedicineOpen access
ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...
- Materials & EnergyOpen access
Machine Learning-Guided Strategy Selection and Condition Prediction for Photoredox Catalysis
Abstract Photoredox catalysis offers powerful opportunities for organic synthesis, yet its broader application remains limited by the difficulty of identifying viable synthetic routines and conditions. Here, we present an experimentally validated, machine-learning-assisted workfl...
- Materials & EnergyOpen access
Pulmonary fibrosis (PF) and acute lung injury (ALI) represent mechanistically interrelated stages along a shared inflammatory-fibrotic disease continuum, both driven by dysregulated macrophage responses and reactive oxygen species (ROS)-mediated signaling. Effective intervention...
- Biology
Abstract Phytochemical investigation of Croton laevigatus yielded six macrocyclic diterpenoids, craeviganoids A–F (1–6), featuring three novel carbon skeletons: two distinct types of 13-membered diterpenoid lactones (1–3) bearing a rare bridgehead alkene, and a 14-membered furano...
- BiologyOpen access
Structure based discovery of antipsychotic-like TAAR1 agonists
Abstract Schizophrenia is a severe mental illness whose current treatments primarily target dopamine and serotonin receptors. These drugs often cause side effects and vary in effectiveness across patients. The trace amine-associated receptor 1 (TAAR1), which modulates monoamine s...
- Health & Medicine
Analysis of Blood Components of Xiangju Tablets Based on UPLC‐QTOF‐MS/MS and Network Pharmacology
ABSTRACT Based on serum pharmacochemistry and network pharmacology, the pharmacodynamic material basis and mechanism of Xiangju tablets (XJPs) in the treatment of rhinitis and sinusitis were discussed. UPLC‐QTOF‐MS/MS technology combined with Compound Discover 3.0 was used to ana...
- Materials & Energy
ABSTRACT Atomically precise metal nanoclusters (metal NCs) provide ideal platforms for probing structure–performance relationship in electrochemical CO 2 reduction reaction (eCO 2 RR). However, how ligand hydrophobicity governs long‐term electrode stability at the molecular level...
- Health & MedicineOpen access
Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition
In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...
- BiologyOpen access
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...
- Materials & Energy
2-Alkynyl-1-Naphthoate:A Reactive and Base-TolerantLeaving Group for Gold(I)-Catalyzed Glycosylation
Abstract 2-Alkynyl-1-naphthoate is disclosed as a reactive, base-tolerant leaving group for gold(I)-catalyzed glycosylation. Relocating the alkyne from C8 to C2 reduces steric congestion, facilitating donor preparation while preserving the anomeric ester under saponification cond...
- Health & MedicineOpen access
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...