Shanghai Institute of Materia Medica

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...

2-Alkynyl-1-Naphthoate:A Reactive and Base-TolerantLeaving Group for Gold(I)-Catalyzed Glycosylation

Abstract 2-Alkynyl-1-naphthoate is disclosed as a reactive, base-tolerant leaving group for gold(I)-catalyzed glycosylation. Relocating the alkyne from C8 to C2 reduces steric congestion, facilitating donor preparation while preserving the anomeric ester under saponification cond...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...