Shandong Center for Disease Control and Prevention

Mechanisms and clinical characteristics of organ injury in severe fever with thrombocytopenia syndrome: a comprehensive review

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease caused by Bandavirus dabieense (commonly referred to as SFTS virus, SFTSV), with a case-fatality rate as high as 30%. Although SFTSV is mainly found in East Asia (China, Japan, and South...

Glyoxal induces arterial injury through the inactivation of receptors and signaling pathways

Glyoxal exposure is associated with a spectrum of adverse health outcomes, including arterial injury. While existing evidence confirms that glyoxal targets oxidative stress and the mitogen-activated protein kinase pathway, the precise underlying mechanism of glyoxal-induced arter...

Joint associations of non-intact family types and health-risk behaviors with mental health outcomes: evidence from a large-scale survey among adolescents in Shandong Province, China

Rising global divorce rates have increased the prevalence of non-intact families, which may be associated with adolescents’ behaviors and mental health. Non-intact family types (NIFTs) and health-risk behaviors (HRBs) are both associated with adolescent mental health, yet previou...

Physical and mental health conditions in men who have sex with men: a global umbrella review of meta-analyses

Men who have sex with men (MSM) face a disproportionate burden of health problems. Prior syntheses among MSM have not comprehensively addressed key areas such as non-communicable diseases, mental health, and comorbidities. This umbrella review aimed to synthesize and evaluate met...

The deubiquitinase PSMD14 accelerates cervical cancer progression, with thiolutin offering a novel therapeutic approach

Abnormal function of deubiquitination enzymes is implicated in cancer progression. However, the role of the 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) in cervical cancer development and its underlying mechanisms remain poorly understood. In our study, we evaluated t...

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...