Servicio de Salud de Castilla La Mancha

Association Between the GMI / HbA1c Ratio and Microvascular Complications in Type 1 Diabetes: A Multicenter Cross‐Sectional Study

ABSTRACT Objective To clarify whether the glucose management indicator (GMI)/glycated haemoglobin (HbA1c) ratio (GMI/HbA1c ratio) is an independent predictor of microvascular complications in Type 1 diabetes (T1D). Design and Methods Multicentre, cross‐sectional, observational st...

Development and Preliminary Psychometric Evaluation of a Questionnaire on Comprehensive Protection, Quality, and Humanization in Pediatric Hospital Care

Background/Objective: We aimed to develop a questionnaire for pediatric healthcare professionals assessing the rights of hospitalized children, service quality, clinical relationships, and care practices and to obtain preliminary evidence of its content validity, internal consist...

Trophic position structures physiological trade-offs between metabolic and detoxification pathways in sympatric passerines

Abstract Resource use links ecological context to organismal performance, yet whether dietary breadth or trophic position is more closely associated with physiological state in wild birds remains unclear. We used a natural trophic gradient in a sympatric passerine assemblage to t...

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...

Prevalence of neuropsychiatric and seizure disorders in neurofibromatosis type 1: a systematic review and meta-analysis

Neurofibromatosis type 1 (NF1) is associated with intellectual disability (ID), autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), emotional and seizure disorders. However, published prevalence estimates vary widely. The aim of this meta-analysis was...

Acceptance of the possibility of simulated patient death among final-year medical students: a repeated cross-sectional study across eight consecutive cohorts

Simulation scenario design has long been guided by a recommendation that the simulated patient should not be allowed to die, on the grounds that a fatal outcome may impair learning and compromise psychological safety. This "no-death paradigm" rests largely on expert opinion and o...

Lifestyle and its relationship with health literacy, sense of coherence and sociodemographic factors in a Spanish primary care population: a multicenter cross-sectional study

Health behaviors are driven by a complex interplay of individual and structural factors. While health literacy and sense of coherence are widely studied as psychosocial enablers of healthy lifestyles, evidence comparing their impact against broader social determinants of health r...

Adherence to the Mediterranean Diet and Academic Performance in University Students: A Systematic Review and Meta-Analysis

Background/Objectives: Adherence to the Mediterranean diet (MedDiet) has been associated with numerous health benefits, yet it is often suboptimal among university students. Its relationship with academic performance (AP), an outcome with potential long-term implications, has not...

High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2–induced prothrombotic state

The pathophysiological mechanisms underlying the hypercoagulable state and thrombotic events associated with COVID-19 remain incompletely understood. To investigate prothrombotic alterations during SARS-CoV-2 infection, we performed an exploratory and integrated analysis of cereb...

Women's Perceptions of Sexual Function During the Postpartum Period: Systematic Review of Qualitative Evidence

INTRODUCTION: Sexuality is a multifaceted aspect of life influenced by several dimensions, including biology, psychology, socioeconomics, and spirituality. Postpartum sexual health remains an understudied and relevant area for women. This systematic review of qualitative studies...

Are exercise benefits in older adults clinically meaningful?: An ancillary and follow-up analysis of a multicenter randomized controlled trial

Physical exercise is beneficial for older adults, but little is known about inter-individual response variability or whether its effects reach clinical significance. We analyzed individual clinically meaningful responses to exercise in older adults. This is an ancillary analysis...

Provincial Differences in Cardiometabolic and Work-Related Health Among Professional Spanish Wildland Firefighters: An Age- and Sex-Adjusted Cross-Sectional Study

Professional wildland firefighters are exposed to substantial physical, thermal, respiratory, and psychosocial demands. This cross-sectional study examined whether cardiometabolic and work-related health indicators differed among the five provinces of Castilla-La Mancha after acc...