Seoul National University Bundang Hospital

Association between smoking status and choroidal thickness in the Korean population: Korea National Health and Nutrition Examination Survey 2017–2021

Smoking has been suggested to influence choroidal circulation and structure, but population-based evidence regarding its association with choroidal thickness remains limited. This cross-sectional, population-based study investigated the association between smoking status and subf...

Vascular Imaging Features and Time-Specific Recurrence Risk After Craniocervical Artery Dissection

Background and ObjectivesCraniocervical artery dissection (CCAD) is a major cause of stroke in young adults, yet its recurrence risk remains poorly defined because of delayed enrollment in prior research. We aimed to determine the temporal distribution of recurrent ischemic strok...

Optimizing the Hinge Length of Chimeric Antigen Receptor with a DdFP-Based Immunological Synapse Biosensor

Abstract Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative cancer immunotherapy, employing genetic engineering to express CARs in patient T cells. CARs are composed of a single-chain variable fragment (scFv), hinge, transmembrane, and intracellular si...

PLLA–ZnO nanowire nano-vaccine orchestrates balanced Th1/Th2 immunity and confers prophylactic antitumor protection

Cancer vaccines require both cellular and humoral immunity for optimal therapeutic efficacy. We previously demonstrated that carcinoembryonic antigen (CEA)-coated poly- l -lactic acid-zinc oxide (PLLA-ZnO) nanocomposites induce strong cellular immunity and therapeutic antitumor e...

Success criteria for dental implants over the past 48 years

More than a century has passed since dental implants were first introduced and documented in the English literature.As the Korean Academy of Implant Dentistry (KAID) celebrates its 50th anniversary, there is a critical need to clarify the dental implant success criteria establish...

Is Transanal Local Excision Oncologically Safe After Chemoradiotherapy? A Multicenter Phase II Study in ycT0–1 Rectal Cancer

PurposeTo evaluate the feasibility of local excision (LE) as an organ-preserving approach in patients with locally advanced rectal cancer showing a good response to neoadjuvant chemoradiotherapy (CRT). Materials and MethodsThis prospective, multicenter, single-arm phase II study...

Association of post-treatment ⁹⁰Y PET/CT–derived mean tumor absorbed dose with treated-lesion progression-free survival after glass-microsphere radioembolization for hepatocellular carcinoma

To assess the prognostic value of post-treatment yttrium-90 PET/CT–based dosimetry and an absorbed dose threshold for progression-free survival in large (> 8 cm) hepatocellular carcinomas treated with transarterial radioembolization. Fifty-eight patients with unresectable hepatoc...

Rehabilitation and airway clearance technique education in nontuberculous mycobacterial pulmonary disease: protocol for the NTM-Rehab study

BACKGROUND: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic, often progressive, respiratory infection with an increasing global incidence that is frequently accompanied by bronchiectasis. Although antimicrobial therapy is the cornerstone of treatment, culture...

Three-Year Outcomes of Drug-Eluting Stents, Drug-Coated Balloons, and Non-Drug-Eluting Devices in Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

Background: Although drug-eluting devices have demonstrated improved efficacy in femoropopliteal artery (FPA) disease, evidence on their long-term clinical outcomes in realworld practice remains limited.Methods: Using data from the multicenter Korean Vascular Intervention Society...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Rapidly Progressive Gastric Poorly Differentiated Neuroendocrine Carcinoma Mimicking Gastrointestinal Stromal Tumor: A Case Report

Poorly differentiated gastric neuroendocrine carcinoma (NEC) represents a rare but highly aggressive malignancy, typically diagnosed at advanced stages, which are associated with poor prognosis. We present a case of a 71-year-old male with a history of distal gastrectomy who deve...

Predictors of Early Versus Late Atrial Tachyarrhythmia Recurrence After Cryoballoon Ablation by Atrial Fibrillation Type

ABSTRACT Introduction Patient characteristics and predictors of early (ERAT) and late (LRAT) recurrence of atrial tachyarrhythmia by atrial fibrillation (AF) type after cryoballoon ablation (CBA) remain poorly defined. Methods Using the Korean Heart Rhythm Cryoballoon Registry (1...

Efficacy of Polyhexamethylene Biguanide Antibacterial Gel Coating of Orthopedic Implants in Infection Control and Immune Modulation

ABSTRACT With the growth of the older adult population and the increasing incidence of traumatic injuries, the use of orthopedic devices has risen significantly. However, in addition to material‐related limitations, one of the most serious challenges associated with these devices...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Bridging primary care with artificial intelligence: toward a global 1.5-Tier Healthcare System

Artificial intelligence is increasingly applied in primary care, yet systematic frameworks linking individual applications to health-system improvement remain lacking. This perspective proposes a “1.5-Tier Healthcare System,” in which AI forms an intermediary layer between primar...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Regional variation and healthcare utilization patterns in Medication-related osteonecrosis of the jaw: A nationwide cohort study in Korea

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication associated with antiresorptive and antiangiogenic agents. This study evaluated regional differences in MRONJ diagnosis and surgical management in Korea. METHODS: Using the National Health In...

Restricted Loss of Life Expectancy in Patients With Acute Myocardial Infarction: A Nationwide KAMIR Registry Study

Background The mortality risk of acute myocardial infarction declines rapidly after the initial period, yet the quantitative measures of residual risk in the follow‐up period remain limited. We aimed to assess restricted loss of life expectancy (LOLE) in patients with acute myoca...

Pituitary magnetic resonance imaging abnormalities and 1-year growth response in children with idiopathic growth hormone deficiency

Purpose: Brain magnetic resonance imaging (MRI) is used to assess anatomical abnormalities in children with idiopathic growth hormone deficiency (IGHD), but its prognostic relevance remains uncertain. We investigated whether structural abnormalities on brain MRI are associated wi...

Patterns of failure after primary treatment and prognostic factors in stage I, grade 2-3 endometrial cancer

Purpose: This study aimed to characterize recurrence patterns and identify prognostic factors in patients with stage I, grade 2-3 endometrioid endometrial cancer. Materials and Methods: We retrospectively analyzed 298 patients with 2009 International Federation of Gynecology and...