Seoul National University Bundang Hospital

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Salivary Digital PCR With Epigenetic Cell Counting Correction as a Feasible Non-Invasive Platform for Longitudinal JAK2V617F Monitoring in Myeloproliferative Neoplasms

Abstract Intensive longitudinal monitoring of somatic mutation variant allele frequency (VAF) is needed to characterize clonal dynamics during therapy in myeloproliferative neoplasms (MPN). Salivary digital PCR, corrected for buccal epithelial DNA contamination by epigenetic cell...

Lymphocyte-predominant inflammation refines lung histopathology scoring in preclinical respiratory viral infection: support from deep learning analysis

Respiratory viral infections such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain major causes of morbidity and mortality. Although lung histopathology is a major endpoint in preclinical studies, conventional H&E-based grading primarily evalua...

Cardiac Reverse Remodeling and Clinical Outcomes Following Angiotensin Receptor‐Neprilysin Inhibitor Therapy in Heart Failure With Reduced Ejection Fraction

Background Cardiac reverse remodeling and associated clinical outcomes following angiotensin receptor‐neprilysin inhibitor (ARNI) therapy in patients with heart failure (HF) with reduced ejection fraction (EF) remain unclear. We investigated differences in 1‐year echocardiographi...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

Beyond body mass index: A contemporary review of obesity and female infertility

Obesity is increasingly understood as a reproductive-metabolic condition that can affect female fertility across the continuum from natural conception to assisted reproductive technology (ART). Excess adiposity may disrupt hypothalamic-pituitary-ovarian regulation, insulin signal...

Seroprevalence and Clinical Characteristics of Hepatitis D Virus Infection in Korean Patients with Chronic Hepatitis B, Liver Cirrhosis, and Hepatocellular Carcinoma

Background/Aims: Hepatitis delta virus (HDV) coinfection exacerbates clinical outcomes in chronic hepatitis B (CHB) patients.With emerging HDV-targeted therapeutics, accurate prevalence and clinical impact data are essential.In this study, the seroprevalence, clinical significanc...

Lipid Burden and Efficacy of Preventive PCI of Vulnerable Atherosclerotic Coronary Plaques: Post Hoc Analysis From the PREVENT Trial

BACKGROUND: Preventive percutaneous coronary intervention (PCI) of non–flow-limiting lesions (fractional flow reserve >0.80) that are high-risk plaques has emerged as a potential strategy to reduce cardiac events. However, identifying which lesions derive the greatest benefit fro...

Sensory gamma entrainment in older adults with or without cognitive impairment: a systematic review and exploratory meta-analysis

Gamma entrainment using sensory stimulation (GENUS) is a noninvasive approach under investigation in older adults with and without cognitive impairment, including Alzheimer’s disease; however, human evidence remains scattered across structural, functional, biomarker, electrophysi...

Criteria-based probable REM sleep behaviour disorder and risk of Lewy body dementia: analyses of a memory clinic cohort and a community cohort

Abstract Background REM sleep behaviour disorder (RBD) is the strongest prodromal marker of alpha-synucleinopathies, but whether a brief questionnaire carries prognostic information for Lewy body dementia is unclear. We tested whether criteria-based probable RBD (pRBD)—a question...

Efficacy of popliteal plexus block for opioid sparing and pain management after lower extremity surgery: a meta-analysis

Background: Postoperative pain management often depends on opioids, despite the associated adverse effects. The popliteal plexus block (PPB) presents a promising technique to reduce opioid consumption in surgeries. Methods: This meta-analysis evaluates the effectiveness of PPB wh...

2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation: a secondary publication

The 2025 Korean Guidelines for Cardiopulmonary Resuscitation provide updated, evidence-based recommendations to optimize the transition from intrauterine to extrauterine life. While approximately 85% of term newborns initiate spontaneous breathing independently, timely interventi...

Analytical Performance Evaluation of the Sysmex XR-9000 Hematology Analyzer in a Clinical Laboratory Setting

Background: Automated hematology analyzers are essential for clinical diagnostics.We evaluated the analytical performance of the Sysmex XR-9000 (Sysmex Corporation, Kobe, Japan) by comparing it with the XN-9000 (Sysmex Corporation) system.Methods: Analytical performance of the XR...

On-Device ECG and Vital-Sign Prediction of 24-Hour Mortality and Unplanned ICU Admission in Emergency Department Patients: A Retrospective Evaluation of MEDI-AI

Background/Objectives: Smartphone-based analysis of electrocardiograms (ECGs) and vital signs may support risk assessment without an integrated electronic health record feed. We evaluated MEDI-AI for 24 h mortality and unplanned intensive care unit (ICU) admission, with secondary...

Large language model–assisted scoring of physician-administered parent interviews for autism screening in young children: a retrospective diagnostic case-control and agreement study

Large language models (LLMs) may assist clinicians in scoring narrative parent-report interviews, but diagnostic discrimination, score agreement, output repeatability, and clinical utility are distinct claims. We evaluated an LLM-assisted workflow for scoring a physician-administ...

Seroprevalence of Toxoplasma gondii among animal-associated workers and companion animals in South Korea

Abstract Toxoplasma gondii is a widely distributed zoonotic parasite at the human–animal interface. However, studies simultaneously evaluating animal-associated workers and companion animals remain limited in South Korea. This multi-regional cross-sectional study aimed to estimat...

Prognostic associations of anthropometric indices with major health outcomes: A nationwide cohort study of 1.1 million adults

Background and Aims The global escalation of obesity necessitates precise tools for assessing diverse health risks. This study aimed to compare the prognostic associations of body mass index (BMI), waist circumference (WC), and the body roundness index (BRI) across multiple cardi...

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial

Evorpacept blocks the CD47–signal regulatory protein α interaction, enhancing antibody-dependent cellular phagocytosis. In the phase 2 portion of ASPEN-06 (a multicenter, open-label, randomized phase 2/3 study), 127 patients with pretreated, human epidermal growth factor receptor...

Prognostic implications of the duration of continuous kidney replacement therapy in 3-month survivors of acute kidney injury: findings from the LINKA cohort

The duration of continuous kidney replacement therapy (CKRT) represents a complex clinical surrogate reflecting the severity of systemic illness, the rate of metabolic recovery, and clinical decision-making regarding treatment discontinuation. The effect of CKRT duration on long-...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...