Second Hospital of Shanxi Medical University

Knowledge, attitudes, and practices regarding Helicobacter pylori resistance among physicians: a multicenter cross-sectional study in Shanxi, China

This study aimed to explore physicians’ knowledge, attitudes, and practices (KAP) regarding Helicobacter pylori ( H. pylori ) resistance to treatment in Shanxi Province, Central China. A multicenter, cross-sectional study was conducted from August to October 2024, enrolling physi...

Ki-67 Proliferation Index Improves the Prognostic Stratification Accuracy of International Staging System in Newly Diagnosed Multiple Myeloma

Objective: To investigate the clinical characteristics and prognostic significance of distinct Ki-67 proliferation indices in patients with newly diagnosed multiple myeloma (NDMM). Methods: A retrospective analysis of clinical data from 307 NDMM patients admitted to the Second Ho...

Focusing on VaIN2 +: Development and validation of a prediction nomogram based on a large colposcopy population

Abstract Introduction Vaginal intraepithelial neoplasia 2 or worse (VaIN2+) has long remained in a largely passive diagnostic pattern due to the lack of specific clinical manifestations and routine screening strategies. This study aimed to explore its clinical characteristics and...

Association of inflammatory biomarkers and pericoronary fat attenuation index with coronary functional ischemia in patients with metabolic dysfunction-associated fatty liver disease

Patients with metabolic dysfunction-associated fatty liver disease (MAFLD) and coronary heart disease (CHD) exhibit systemic and coronary inflammation. However, the value of integrating systemic inflammatory biomarkers and the pericoronary fat attenuation index (FAI) for identify...

Transillumination improves lymph node yield in left-sided colorectal cancer: an ambispective cohort study

Accurate lymph node (LN) staging is essential for prognosis and treatment decisions in colorectal cancer (CRC). Existing methods to assist LN retrieval, such as fat-clearing and methylene blue staining, improve yield but are complex, time-consuming, and require additional reagent...

Circ_0000745 Attenuates Sepsis-Induced Acute Kidney Injury Via the MiR‑671‑5p/IGFBP3 Axis, with Associated Changes in Autophagy-Related Markers

Sepsis-induced acute kidney injury (SAKI) is a frequent and life-threatening complication that currently lacks standardized therapeutic strategies. Circular RNAs have emerged as critical regulators in SAKI pathogenesis, and circ_0000745 has been identified as significantly downre...

The relationship between serum FSTL1 levels and bone destruction in patients with ankylosing spondylitis

A typical autoimmune disease, ankylosing spondylitis (AS), is characterized primarily by chronic inflammation of the axial skeleton and destruction of osseous structures. Follistatin-like protein 1 (FSTL1) is a glycoprotein that regulates inflammation and bone metabolism and has...

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF ‐3α‐ BNIP3 Axis

Mitochondrial quality control is severely impaired in the aging heart, largely attributed to disrupted mitophagy homeostasis. However, the key molecular drivers remain poorly defined, and the translational value of mitochondria-targeted therapy for cardiac aging is still underexp...

The Role of Eccentric Contraction Training in the Postoperative Rehabilitation of Patients With Total Knee Arthroplasty

ABSTRACT Background Eccentric contraction training may be associated with improved functional recovery after total knee arthroplasty (TKA), but its effects on pain, range of motion, and patient‐reported outcomes during the early postoperative period remain unclear. This randomize...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

Association between sarcopenia and hypertension: results from large databases in China and the United States

Sarcopenia and hypertension are prevalent conditions with substantial public health implications. However, whether their association is consistent across different populations remains unclear. This study aimed to investigate the association between sarcopenia and hypertension usi...

A dual GLP-1/GIP agonist inhibits oxidative stress in diabetic rats with cerebral ischemia-reperfusion injury by activating the Nrf2/ARE signaling pathway

Stroke is the leading cause of disability-affected life years in China, posing a great social hazard. Diabetes is a chronic disease that seriously affects human health that can aggravate cerebral ischemia - reperfusion injury. Oxidative stress is the main mechanism through which...

Stress hyperglycemia ratio as a risk factor for delirium in older intensive care unit patients: a retrospective cohort study

Delirium is a severe neurocognitive complication in older ICU patients, associated with poor outcomes. The stress hyperglycemia ratio (SHR), reflecting acute hyperglycemia relative to chronic glycemic control, may predict adverse outcomes. This study examined the association betw...

Small extracellular vesicles induced by Angiotensin-(1-7) enhance cardioprotection following myocardial ischemia-reperfusion injury

Although Angiotensin-(1-7) [Ang-(1-7)], a non-classical peptide of the renin-angiotensin system (RAS), is widely recognized for alleviating cardiovascular stress through activation of the Mas receptor. we identified a largely Mas receptor-independent pathway that expands its ther...

Distribution of human papillomavirus in cervical, vaginal and vulvar lesions: a single-center retrospective study from Shanxi, China

Unlike the well-studied cervical cancer caused by human papillomavirus (HPV), there is a lack of epidemiological data on HPV, which covers the entire lower genital tract and has regional characteristics. This study investigated the HPV distribution in cervical, vaginal and vulvar...

Noise‐Resistant Correlated Biphoton Imaging Based on the Superbunching Emission From Single Colloidal Quantum Dots

ABSTRACT Quantum‐correlated techniques enable high‐contrast and super‐resolution imaging through the feature of correlated photons. The superbunching effect with a second‐order correlation larger than 2, i.e., g (2) (0) > 2, demonstrates the existence of strong correlations betwe...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

The genetic association between celiac disease and risk of functional dyspepsia

Celiac disease (CeD) is a common autoimmune disease of the small intestine triggered by ingesting gluten-containing foods. Chronic symptoms are characteristic of functional dyspepsia (FD), including chronic epigastric pain and burning. The clinical and genetic overlap between FD...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

OBJECTIVE: Uterine cancer mortality is rising in the U.S. while other cancer deaths decline, posing a major public health challenge. High BMI is the strongest modifiable risk factor, but its full burden and associated inequalities remain poorly characterized. METHODS: Using data...