Second Hospital of Hebei Medical University

Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Background Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. Methods We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical...

Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer

Background Citrullination, a post-translational modification catalyzed by protein arginine deiminases (PADIs), has been implicated in malignant progression across multiple cancer types. However, its cellular distribution, functional significance, and role in microenvironment remo...

MD-Mamba: A multi-scale dilated state-space network for breast cancer histopathology image classification

Background Automated breast histopathology classification requires models that can capture both local cellular morphology and broader tissue architecture while remaining computationally efficient. Methods We developed MD-Mamba, a multi-scale dilated state-space network with dual-...