Second Hospital of Hebei Medical University

XGBoost–SHAP-based interpretable predictive website for postoperative in-hospital mortality in patients with acute aortic dissection

Developing a convenient and accurate prognostic model for patients with acute aortic dissection (AAD) using routine demographic and clinical data is challenging. This study aimed to develop an interpretable web-based prediction model using extreme gradient boosting with Shapley a...

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

ABSTRACT Pigs share a germ cell regulatory network highly similar to that of humans, yet lack a robust system for inducing and expanding germ cells from pluripotent stem cells, impeding large‐animal gametogenesis research. Here, we established a modular platform capable of effici...

Evaluation of the efficacy of oral propranolol combined with pulsed dye laser versus monotherapy with oral propranolol in the treatment of mixed infantile hemangiomas

Oral propranolol is first-line for problematic infantile hemangiomas (IHs) but often leaves superficial residual lesions. This study assessed the efficacy and safety of adding pulsed dye laser (PDL) to propranolol versus propranolol alone for mixed IHs. This single-center retrosp...

Association between respiratory phenotypes and successful ventilator liberation in early-onset and late-onset ARDS: a multicenter cohort study

Early-onset and late-onset acute respiratory distress syndrome (ARDS) differ in clinical course and outcomes, but their longitudinal respiratory trajectories remain unclear. We aimed to characterize respiratory trajectories in early- and late-onset ARDS and identify trajectory-ba...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Clinical and imaging predictors of cerebrovascular stroke in patients with acute isolated dizziness/vertigo: a retrospective cohort study

Abstract Background Acute isolated dizziness/vertigo represents a significant diagnostic challenge, as it can be the sole manifestation of posterior circulation stroke. This study aimed to identify clinical and imaging features associated with stroke in a specific high-risk subgr...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Brodifacoum poisoning complicated by intestinal necrosis

Dear Editor,Brodifacoum is a potent, long-acting second-generation 4-hydroxycoumarin anticoagulant rodenticide that inhibits vitamin K epoxide reductase, impairing hepatic synthesis of coagulation ...

Prenatal management and outcomes in mirror syndrome: report of two cases

Mirror syndrome (MS) is a rare obstetric complication characterized by fetal hydrops, placental edema, and maternal edema accompanied by the triad of hemodilution. MS is often misdiagnosed as preeclampsia, and its management must target the underlying fetal etiology. Currently, t...

A Novel Suture-Based Otoplasty Technique Combining Figure-of-Eight and Mattress Sutures for Prominent Ear Correction: A Retrospective Study of 89 Patients

BACKGROUND: Prominent ear is a common congenital deformity that can cause significant aesthetic and psychosocial concerns. This study introduces a novel suture-based otoplasty technique that combines figure-of-eight and mattress sutures to achieve natural-appearance aesthetic out...

The membrane skeleton density of red blood cells in MYH9 -related disease patients is decreased

MYH9-related disease (MYH9-RD) is a rare autosomal dominant disorder caused by mutations in MYH9 gene, which encodes the heavy chain of nonmuscle myosin IIA. Nearly all MYH9-RD patients present with macrothrombocytopenia, characterized by decreased platelet count and increased pl...

Effectiveness and clinical characteristics of biologic switching in severe asthma patients with inadequate response to initial biologic therapy: a systematic review

Bronchial asthma (hereafter referred to as asthma) is a common chronic inflammatory airway disease affecting more than 300 million people worldwide. Although most patients achieve control with conventional or biologic therapies, a subset of patients with severe asthma has an inad...

Correlation Between CT Manifestations and Treatment Strategy in Nasal Bone Fractures

Objective: To determine the association between detailed CT manifestations of nasal bone fracture and treatment strategy, emphasizing whether CT-derived structural severity can stratify conservative treatment, closed reduction, and open reduction/septorhinoplasty. Methods: This r...

New findings of swept-source optical coherence tomography angiography in Sturge–Weber syndrome with circumscribed choroidal hemangioma: a case report

Abstract Background Circumscribed choroidal hemangioma is not associated with systemic diseases,while it can also occasionally occur in Sturge-Weber syndrome patients. Swept-source optical coherence tomography angiography (SS-OCTA) offers a non-invasive imaging modality for diagn...

Nocardia gipuzkoensis: clinical characterization, identification, and antimicrobial susceptibility

Nocardia gipuzkoensis was first described as a novel species in 2020. To date, infections caused by N. gipuzkoensis have rarely been reported. The prevalence of N. gipuzkoensis may be severely underestimated because N. gipuzkoensis was misidentified as Nocardia abscessus with 16...

Association between disease awareness and prognosis in patients with glioblastoma

This study aimed to evaluate whether disease awareness among Chinese patients with glioblastoma was associated with prognosis. This single-center, retrospective cohort study included consecutive patients diagnosed with glioblastoma between February 2009 and August 2020. Disease a...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Left bundle branch area pacing in atrial fibrotic cardiomyopathy manifesting as atrial standstill: two case reports and mechanistic insights

Atrial standstill (AS) is a rare arrhythmogenic disorder characterized by the complete absence of atrial electrical and mechanical activity, most commonly resulting from atrial fibrotic cardiomyopathy (AFC). Optimal management remains challenging, particularly when selecting an a...

The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a novel marker for periodontitis risk

Periodontitis has been linked to dyslipidemia, but the relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and periodontitis remains unclear. This study aimed to investigate their association and develop a risk pr...

Expression, association with clinicopathological features and prognostic potential of FOXR2, mTOR, HIF−1α and PKM2 in high−grade serous carcinoma of the ovary

High−grade serous carcinoma (HGSC) of the ovary is the most common and deadly subtype of gynecological malignancy. More and more studies have shown that Forkhead Box R2 (FOXR2) is a carcinogenic driver that can enhance cell growth and tumor formation. However, the role of FOXR2 i...