Second Affiliated Hospital of Nanjing Medical University

Multimodal Transformer Integrating CT and Pathology for Postoperative Risk Stratification in Stage I Non–Small Cell Lung Cancer

A biologically interpretable multimodal artificial intelligence framework outperformed guideline-based postoperative risk stratification for stage I non–small cell lung cancer and identified patients who would benefit from adjuvant therapy.

TyG-ABSI and TyG-WWI as insulin-resistance body shape markers of mortality in middle-aged and older adults within the cardiovascular-kidney-metabolic framework

Insulin resistance, adiposity, kidney dysfunction, and cardiovascular disease are closely interconnected in middle-aged and older adults and are central to the cardiovascular-kidney-metabolic (CKM) framework. Triglyceride-glucose (TyG)-related indices combine routine lipid, gluco...

Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy

Abstract Combining chemotherapy and immunotherapy shows great promise for treating esophageal squamous cell carcinoma (ESCC), but its effectiveness is hindered by the immunosuppressive tumor environment and challenges in drug delivery. Recent research has focused on cell membrane...

Age-Associated Differences in Facial Skin Structure in Chinese Women: a Cross-Sectional Study

Facial skin aging is a process leading to structural degradation and visible phenotypical changes. Prior studies examined age-related skin parameters and suggested accelerated changes occurring in the early 30s, yet precise timing remains insufficiently defined, and few assessed...

Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study

BACKGROUND: Influenza, a prevalent disease, significantly threatens public health. Accurately predicting severe influenza occurrences is crucial for developing personalized prevention strategies and treatment plans. AIMS: This study aimed to construct a highly interpretable model...

Operating room spatial layout, capacity utilization, and resource efficiency: evidence from a tertiary hospital in China

Purpose Operating rooms (ORs) are among the most resource-intensive hospital units. This study examines how OR spatial layout influences surgical preparation time, staff movement, equipment utilization, patient flow, and OR utilization in a large tertiary hospital in China. Desig...

Intraoperative free-running electromyography as a dynamic adjunct during microvascular decompression for hemifacial spasm

To characterize intraoperative free-running electromyography (EMG) patterns during microvascular decompression (MVD) for hemifacial spasm (HFS) and to evaluate their potential clinical significance, including their distribution across key surgical steps, their utility in distingu...

METTL16 supports arginine biosynthesis and suppresses IL-1β production to attenuate allergic asthma

Allergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergic asthma and in a murine model...

Smarter AI, Healthier Students? How Perceived AI Assistant Intelligence Shapes Medical Students’ Mental Health Through Learning Goal Progress and Academic Anxiety

As artificial intelligence (AI) adoption grows in medical education, AI assistants have become important learning support tools for medical students. However, existing research has primarily focused on learning performance and technology adoption, while little is known about how...

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

ABSTRACT Renal allograft interstitial fibrosis/tubular atrophy (IF/TA) is the pathological hallmark of chronic renal allograft dysfunction (CAD) and endothelial‐to‐mesenchymal transition (EndMT) has been implicated as one of the key triggering factors. Here, we identified tumor n...

Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis

Onvansertib (ONV) is a selective inhibitor of polo-like kinase 1 (PLK1) and has promise in treating cancer. However, its potential effects on male reproductive function remain insufficiently characterized. In this study, male mice received clinically relevant doses of ONV by intr...

Machine learning for predicting prolonged length of stay among children with infectious mononucleosis

Infectious mononucleosis (IM) is usually self-limited in children but can require a prolonged inpatient course. Prediction of prolonged length of stay (PLOS) from information available at admission may inform the development of future early risk-stratification approaches; however...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

Abstract Postoperative recurrence remains a critical challenge in cancer management, necessitating innovative strategies to reshape the tumor microenvironment (TME) and enhance immune surveillance. This review highlights nanomedicine‐driven breakthroughs in postoperative immunoth...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus

The early-life gut microbiome may influence susceptibility to antibody-mediated neonatal autoimmunity, but the underlying mechanisms remain poorly understood. We investigated whether gut microbial functional capacity and metabolites influence autoantibody-dependent immune activat...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Silicon Nitride Nanofilm Functionalized Titanium Mesh for Boosting Osseointegration by Macrophage-Related Immunomodulation

Abstract Titanium mesh-supported guided bone regeneration (TM-GBR) has emerged as a clinically effective strategy for alveolar bone augmentation in complex defects, primarily through its ability to preserve osteogenic space and correct bone volume deficiencies. However, due to th...

Learning curve for single-surgeon robot-assisted single-port extraperitoneal radical prostatectomy

To evaluate surgical outcomes of robot-assisted single-port extraperitoneal radical prostatectomy (E-sp-RALP) performed by a single surgeon and to characterize the procedural learning curve. Clinical data from 50 consecutive E-sp-RALP procedures performed at the Affiliated Hospit...

Pachymic acid exhibits synergistic antitumor efficacy with lenvatinib in hepatocellular carcinoma by targeting PPARγ to inhibit glycolysis

Lenvatinib is a first-line treatment for hepatocellular carcinoma (HCC), though drug resistance may develop with long-term use. to investigate the potential of pachymic acid to enhance lenvatinib’s anti-tumor efficacy. HepG2 and LM3 cells were exposed to pachymic acid and/or lenv...