Second Affiliated Hospital of Nanjing Medical University

Piezo1 drives fibroblast activation in epidural fibrotic remodelling via the ET-1/HIF-1α pathway

Aims: Epidural fibrosis is a major cause of failed back surgery syndrome following laminectomy. While previous studies have focused primarily on the early phases of scar formation, fibrotic remodelling remains poorly understood. This study aimed to investigate the interaction bet...

Air pollution-related proteomic signatures, molecular mediators, and AF-free life loss: A large-scale proteome-wide analysis

Background Air pollution is a major environmental risk factor for Atrial Fibrillation (AF). We aimed to derive robust, pollutant-specific proteomic signatures to elucidate the biological mechanisms and evaluate their potential risk-stratification utility. Methods We analyzed plas...

Sigh ventilation versus conventional protective ventilation in cardiac surgery: a proof-of-concept randomized controlled trial

Lung protective ventilation is crucial for preventing ventilator-induced lung injury in cardiac surgery. The protective role of a low tidal volume (V T ) has been established, whereas the added protection afforded by lung recruitment remains uncertain. We investigated whether sig...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

LPA deficiency in follicular fluid linked to impaired oocyte maturation through BCAA metabolism-mediated mitochondrial dysfunction

Abstract Lysophosphatidic acid (LPA) is known to be crucial for oocyte developmental competence, but the underlying molecular mechanisms remain unclear. In this study, we investigated the mechanistic relationship between follicular fluid LPA levels and oocyte quality determinants...

Effects of Parathyroidectomy on Muscle Mass, Strength, and Physical Function in Uremia-Associated Secondary Hyperparathyroidism

Objective: To investigate the effects of parathyroidectomy (PTX) on muscle mass, muscle strength, and motor function at different postoperative stages in uremic patients with secondary hyperparathyroidism (SHPT). Methods: A total of 47 uremic patients with SHPT who underwent PTX...

Per- and PolyfluoroalkylSubstances in Pediatric CerebrospinalFluid: Evidence of Central Nervous System Exposure

Abstract Per- and polyfluoroalkyl substances (PFAS) have been implicated in neurodevelopmental toxicity, yet direct evidence of their presence within the central nervous system (CNS) of children remains limited. We quantified 12 PFAS in cerebrospinal fluid (CSF) samples from 47 p...

Low tube voltage with deep learning and freezing for coronary CTA in obese patients with suspected CAD

Objective to investigate the application of low tube voltage combined with deep learning reconstruction algorithms and freeze technology in obese patients undergoing coronary computed tomography angiography (CCTA). A total of 100 patients with a BMI of 28 kg/m2 or higher who unde...

Proteome-wide interaction study of fatty acids and mortality in the UK Biobank

The heterogeneity in associations between circulating fatty acids (FA) and mortality remained underexplored. Proteomics can profile the human physiological status. This study aimed to estimate interactions between FA and proteins in relation to mortality. We randomly divided 30,1...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

Preoperative triglyceride–glucose index and 30-day surgical site infection in OSCC patients without documented diabetes: a retrospective cohort study

Surgical site infection (SSI) remains an important complication after oral squamous cell carcinoma (OSCC) surgery. Although diabetes is a recognized infection risk factor, metabolic vulnerability in patients without documented diabetes is less understood. The triglyceride–glucose...

The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure

Patients with chronic heart failure (CHF) have a high mortality rate. The aim of this research is to examine the clinical value and molecular mechanisms of the lncRNA T cell receptor gamma chain-associated AS1 (TRG-AS1) in CHF. The TRG-AS1 expression in 116 CHF patients was asses...

A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases

Dysregulated activation of the stimulator of interferon genes (STING) pathway underlies various inflammatory and autoimmune pathologies. Since STING oligomerization is fundamental to its biological function, targeted modulation of this polymerization process presents a promising...

Monoclonal immunoglobulin‐associated kidney lesions with coexistent pathological patterns: clinicopathological features and outcomes

AIMS: Monoclonal gammopathy-associated kidney lesions typically present with a single pathological pattern, but the coexistence of multiple patterns in the same patient is rare and poorly characterized. This study aimed to delineate the clinicopathological spectrum and outcomes o...