Second Affiliated Hospital of Harbin Medical University

Chlorambucil-LoadedNanomicelles against HepatocellularCarcinoma

Abstract For hepatocellular carcinoma (HCC) therapy, an NQO1-responsive chlorambucil-loaded nanomicelle (CLB-AZO-mPEG5) was designed and synthesized to overcome the poor water solubility of chlorambucil and to explore its mechanism against HCC. CLB-AZO-mPEG5 was constructed by co...

Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy

Intrathecal delivery for central nervous system (CNS) therapy lacks spatiotemporal control due to spinal canal anatomical constraints, especially at human scale. We developed an adaptive magnetic nanorobotic platform enabling multimode swarm mobility for in vivo spinal canal navi...

A Multi-omics Regulated Cell Death Framework Defines Immune Phenotypes and Guides Precision Therapy in Colorectal Cancer

Colorectal cancer (CRC) is molecularly and immunologically heterogeneous, contributing to variable treatment response. Because regulated cell death (RCD) intersects with tumor metabolism, immune regulation, and therapeutic susceptibility, we built an RCD-centered framework for CR...