Second Affiliated Hospital of Guangzhou Medical University

A novel biomarker combination of adenosine deaminase and total bile acids for predicting 3-year coronary artery disease risk in middle-aged and older hospitalized patients

Coronary artery disease (CAD) onset is a leading cause of mortality and morbidity. Short-term risk assessment, which generates greater urgency than long-term estimates, can prompt immediate preventive actions. However, validated biomarkers and tools for near-term prediction are s...

Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays

The high cost and poor portability of external infrared thermal imagers have limited the widespread adoption of photothermal lateral flow immunoassays (PT-LFIAs) in on-site testing. To address this, we developed a smartphone-based handheld Thermal Contrast Amplification (TCA) Rea...

Shear Wave Elastography of the Tibial Nerve and Lower Limb Nerve‐Muscle‐Tendon Complex in Diabetic Peripheral Neuropathy

Objectives To investigate the associations among diabetic peripheral neuropathy (DPN), diabetic tendinopathy, and diabetic myopathy and their respective influencing factors using shear wave elastography (SWE). Methods This study enrolled 65 diabetic patients (22 with DPN [PN‐DM g...

Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients

ABSTRACT Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug‐induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (E...

Cognition, attitudes, and willingness toward biobank donation among the older adults: a cross-sectional survey of 1,143 participants in China

Abstract Background Biobanks are fundamental infrastructures for medical research, and their sustainable development depends on public participation and support. Older adults are at high risk of age-related diseases, making their biospecimens particularly valuable for scientific...

Engineering Nanoparticles to Navigate Biological Barriers for Deep Tumor Penetration

Deep and spatially uniform drug delivery remains a major challenge in nanomedicine for solid tumor therapy. During delivery, nanoparticles must sequentially traverse multiple biological barriers, from systemic circulation and tumor accumulation to vascular extravasation, basement...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...

Clinical features of oxcarbazepine-associated cutaneous reactions in patients with bipolar disorder: a retrospective case series

Oxcarbazepine (OXC) is a second-generation antiepileptic drug that has been used in selected clinical settings as an alternative or adjunctive treatment option for bipolar disorder (BD). However, reports describing OXC-associated cutaneous reactions in patients with BD remain lim...

Epigenetic training licenses naïve CD8 + T cell metabolic fitness and function

Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8 + T cells for future activation. H2A.Z def...

Saquinavir inhibits pyroptosis by regulating NLRP3 degradation to alleviate acute lung injury

Background In critically ill patients, sepsis can precipitate acute lung injury (ALI), a syndrome with high incidence in intensive care settings. Pyroptosis plays an important role in ALI, highlighting its potential as a drug target. The NLRP3-mediated classical pyroptosis pathwa...

Pan-cancer screening and integrative multi-omics and deep learning reveal the prognostic significance of an IBD-CRC shared host–microbe signature in bladder urothelial carcinoma

Background The prognostic relevance of inflammatory bowel disease (IBD)–colorectal cancer (CRC) shared host–microbe signatures in non-intestinal epithelial malignancies remains unclear. This study aimed to evaluate the prognostic and biological significance of an IBD-CRC shared h...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Burden dynamics of pulmonary arterial hypertension in China and the G20 aggregate: a comparative analysis based on the global burden of disease study 2023

BACKGROUND: Pulmonary arterial hypertension (PAH) causes substantial premature mortality and disability. Updated evidence comparing long-term PAH burden in China with the Group of Twenty (G20) aggregate remains limited. We assessed changes from 1990 to 2023 and projected future t...

Genomic and transcriptomic landscape of overweight Chinese breast cancer reveals NOTCH2 mutation–mediated endocrine resistance and therapeutic strategies

Abstract Background Obesity (OB) and overweight (OW) are common in patients with breast cancer and are associated with inferior outcomes, yet their impact on tumor molecular architecture remains incompletely understood. This study aimed to define the genomic and transcriptomic fe...

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

ABSTRACT Intrauterine injury triggers a self‐reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with h...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Neonatal hypoxia promotes pulmonary hypertension by upregulating ALKBH5 expression

Postnatal hypoxia in high-altitude regions drives pulmonary developmental impairment in neonates, which may subsequently progress to pulmonary hypertension and right ventricular failure. N6-methyladenosine (m6A) RNA modification regulates mRNA fate and cellular responses to stres...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

IS 26 -mediated circular bla KPC transposon in ST2483 Pseudomonas aeruginosa

ABSTRACT The global spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a critical clinical threat, with bla KPC as a key mobile carbapenem resistance gene. Here, we investigated a novel bla KPC-2 genetic element and its transmission in clinical ST2483 isolate PA10...