Second Affiliated Hospital of Chongqing Medical University

Graph neural network-based service migration decision in vehicular networks

Abstract The rapid development of the Internet of Vehicles (IoV) has led to an exponential increase in the number of latency sensitive and computationally intensive tasks. Due to the limitations of onboard computing resources in vehicles, offloading these tasks generated during v...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

Abstract Expanding the repertoire of usable E3 ubiquitin ligases remains a critical challenge in the field of targeted protein degradation. For the emerging E3 ligase Kelch domain‐containing protein 2 (KLHDC2), currently reported ligands have a carboxylate moiety in common that m...

Assessing the content quality of Douyin and Bilibili as health information sources for pulmonary tuberculosis: a cross-sectional study

Pulmonary tuberculosis (PTB) remains a major global infectious disease, and short-video platforms are increasingly used for health information seeking. However, the quality, reliability, disease-specific accuracy, and safety of PTB-related videos on major Chinese platforms have n...

Synergistic catalytic therapy of severe acute pancreatitis using gold-doped prussian blue nanozymes via targeting ROS-NLRP3 inflammatory cascade

Severe acute pancreatitis (SAP) is characterized by a complex and poorly understood pathogenesis, with a lack of specific therapeutic agents. Herein, we develop morphology-engineered gold-doped Prussian blue nanozymes (AuPB), designed as reactive oxygen species (ROS) scavengers f...

Clues From the Device: Individualized Programming to Solve a Pacing‐Facilitated AVNRT

ABSTRACT A dual‐chamber pacemaker patient with sick sinus syndrome presented with a slow, long‐RP′ tachycardia. Device interrogation revealed that a spontaneous PVC reset the tachycardia, excluding atrial tachycardia. A subsequent atrial paced beat advanced the next QRS, excludin...

Validation of Newcastle ENDOPREM for assessing patient experience with colonoscopy: a multicenter prospective study

Patient experience is a key quality indicator for colonoscopy, yet standardized assessment tools are lacking in China. The Newcastle ENDOPREM scale has shown promise internationally but requires validation in China. To translate, adapt, and preliminarily evaluate the psychometric...

Regional ventilation at EIT-guided PEEP and mortality in severe ARDS: a prospective observational study

Severe acute respiratory distress syndrome (ARDS) is characterized by regional mechanical heterogeneity and systemic inflammation. Electrical impedance tomography (EIT) can individualize positive end-expiratory pressure (PEEP), but the prognostic value of EIT-derived variables me...

Bone cement pulmonary and intracardiac embolism following percutaneous vertebroplasty: a case report and literature review

Pulmonary embolism and intracardiac cement embolism caused by venous leakage of bone cement are the most serious complications following percutaneous vertebroplasty. Although the incidence of such events is low, they are insidious due to variable clinical symptoms, prone to being...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, with podocyte injury driving disease progression. Mitochondrial dysfunction and ferroptosis contribute to podocyte loss, yet the underlying molecular mechanisms remain incompletely understood. The anti-a...

Renal tubule-targeted biomimetic nanodrugs achieve precise AKI treatment by halting pro-inflammatory crosstalk between proximal tubular epithelial cells and macrophages

Acute kidney injury (AKI) is a critical clinical disorder characterized by high incidence, high mortality, and numerous complications. However, current supportive therapies cannot reverse established injury, leading to poor outcomes in some patients, and thus, necessitating the d...

Serum neutrophil elastase as a potential non-invasive biomarker for assessing hepatic fibrosis in chronic hepatitis B patients

The role of neutrophil elastase (NE) in liver fibrosis caused by chronic hepatitis B (CHB) has not been fully clarified. This study sought to measure serum NE concentrations in individuals with CHB and to determine whether NE could serve as a noninvasive indicator for assessing C...

Leptomeningeal fibroblasts promote glioblastoma progression by regulating cerebrospinal fluid dynamics

Abstract Cerebrospinal fluid contributes to homeostasis in the central nervous system, but how its dynamics are altered in glioblastoma is unclear. We find that glioblastoma drives leptomeningeal perivascular fibrosis that is associated with impaired fluid transport and clearance...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Paeoniflorin Alleviates Oxygen–Glucose Deprivation/Reoxygenation Injury by Mediating Crosstalk Between Neurons and Endothelial Cells Through the VEGF/PI3K-AKT/mTOR Pathway

Background/Objectives: Cerebral ischemia–reperfusion injury (CIRI) poses therapeutic challenges because of oxidative stress, blood–brain barrier disruption, and neuronal apoptosis, limiting current treatments. Paeoniflorin (PF) from Paeonia lactiflora has neuroprotective potentia...

ElectrochemiluminescenceMicroscopy

Abstract Electrochemiluminescence (ECL) microscopy is an emerging imaging technology that combines electrochemistry with optical microscopy. It operates without external light excitation, effectively eliminating photobleaching, phototoxicity, and scattered light noise, and thus e...

Temporal dynamics of PrEP adherence, self-efficacy, and risk perception among men who have sex with men in western China: a cross-lagged panel network analysis

<title>Abstract</title> Background Pre-exposure prophylaxis (PrEP) effectively reduces HIV infection risk among men who have sex with men (MSM), but its benefit depends on adherence. The longitudinal item-level relationships among PrEP adherence, self-efficacy, and risk perceptio...

TREM2 regulates continual efferocytosis of apoptotic neurons by monocyte-derived macrophages via AKT-PFKFB2-mediated glycolytic reprogramming after acute ischemic stroke

Efficient clearance of apoptotic neurons is crucial for mitigating secondary injury after acute ischemic stroke (AIS). Although monocyte-derived macrophages (MDMs) rapidly infiltrate the ischemic brain and upregulate triggering receptor expressed on myeloid cells 2 (TREM2) expres...