Second Affiliated Hospital of Anhui Medical University

Endoscopic Endonasal Approach to the Medial Aspect of the Temporomandibular Joint Region

ABSTRACT Background The temporomandibular joint (TMJ) region is the most superolateral aspect of exposure via an endonasal corridor, while studies regarding the endonasal approach to this specific region are lacking. This study aimed to provide a detailed step‐by‐step surgical te...

Preprocedural estimated glomerular filtration rate and all-cause mortality after TIPS in cirrhosis: a single-center retrospective cohort study

Abstract Background : Renal dysfunction is increasingly recognized as an important determinant of prognosis in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS). However, the prognostic value of preprocedural estimated glomerular filtration r...

Altered Intersubject Variability of Morphological Connectivity in Cerebral Small Vessel Disease and Its Associations With Gene Expression and Cell Types

Background Cerebral small vessel disease (CSVD) is a heterogeneous disorder; however, interindividual variability in morphometric brain connectivity remains unclear, as does its association with gene expression. Methods We enrolled 65 patients with CSVD and 35 healthy controls. I...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Mechanism of HO-1 in alleviating sepsis-associated acute kidney injury via regulating mitochondrial proteostasis and targeted intervention with DNA nanomaterials

Sepsis-associated acute kidney injury (S-AKI) is a major driver of systemic mortality and chronic renal dysfunction, yet effective mechanism-based interventions are lacking. Clinical analysis revealed significant oxidative stress imbalance in patients with S-AKI, characterized by...

Discovery of Novel Pyridazine-Containing Nicotinamide Derivatives as Potent FTO Inhibitors for Acute Myeloid Leukemia

Abstract FTO has been recognized as a promising therapeutic target for acute myeloid leukemia (AML). However, the development of FTO inhibitors with anti-leukemia effects was still limited. Here, based on reasonable design and SAR, a total of 67 compounds were synthesized, among...

THBS1+ macrophages fuel pathogenic inflammation in alcohol-associated liver disease.

BACKGROUND: Alcohol-associated liver disease (ALD) is one of the most common chronic liver diseases worldwide, with a pathological spectrum ranging from simple steatosis to steatohepatitis and, ultimately, cirrhosis. Severe alcohol-associated hepatitis (sAH) arises acutely within...

Differential Psychological Effects of Daytime and Nighttime Heat Exposures on Anxiety: A Randomized Crossover Trial

Abstract Although heat exposure has been linked to adverse mental health outcomes, little is known about the different psychological effects of daytime and nighttime heat exposure. This study employed a randomized controlled crossover trial design. Between July and August 2025, 4...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Hsa_circ_0001944 promotes colorectal cancer progression through the miR-665/IGF2BP1/PKM2 axis-mediated glycolysis

Colorectal cancer (CRC) is a highly heterogeneous malignancy with a poor prognosis. Although previous studies have suggested that circular RNA hsa_circ_0001944 is involved in CRC progression, its precise biological role remains unclear. This study aimed to investigate the functio...

Senescent pulmonary epithelial cells-derived S100A10 drives epithelial-fibroblast crosstalk through inhibiting vimentin ubiquitination in pulmonary fibrosis

Pulmonary fibrosis is a chronic, lethal, and ageing-associated interstitial lung disease of unknown aetiology, involves pulmonary epithelial cell senescence and fibroblast activation. However, the underlying mechanism remains elusive. This study aims to investigate the role and p...

Structural correlates of attentional performance in children with ADHD and their transcriptomic and neurotransmitter architectures

Attention deficits are a core feature of attention deficit hyperactivity disorder (ADHD), yet the biological architecture underlying attentional variation remains incompletely understood. We integrated structural MRI, transcriptomics, and neurotransmitter mapping to investigate a...

Regulatory roles of G-quadruplexes and G-quadruplex-binding proteins across the enhancer and promoter of the HBV genome

Hepatitis B virus (HBV) infection poses a global threat to human health due to the limited availability of effective treatment options. Recent studies have shown that the structures of G-quadruplex (G4) are related to the pathogenesis of the virus and potential targets for antivi...

Driver gene-based prognostic model benchmarked against machine learning survival models is associated with a CAF–TGFβ–EMT-like phenotype in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is molecularly heterogeneous, limiting conventional prognostic tools. Whole-genome resequencing of six HCC cases was used only to filter candidates. Somatically mutated genes were intersected with HCC-annotated entries from five predefined driver re...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Lactate-induced H3K9 lactylation disrupts the inner blood–retinal barrier by activating the PTK2–FMNL2 axis in diabetic retinopathy

Disruption of the inner blood–retinal barrier (iBRB) is a major cause of vascular leakage and vision impairment in diabetic retinopathy (DR), yet the metabolic mechanisms driving endothelial barrier failure remain incompletely understood. Here, we investigated whether lactate-ind...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Gestational Exposure to the Food Processing Contaminant 3-MCPD Impairs Fetal Growth by Disrupting Placental Taurine Metabolism to Drive Vascular Senescence

Abstract 3-Monochloro-1,2-propanediol (3-MCPD), a common food contaminant, induces fetal growth restriction in mice by triggering senescence in the placental vasculature. Transcriptomic analysis reveals suppression of the taurine–hypotaurine pathway through downregulation of Fmo1...

SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease

Aims: Despite major advances with sodium–glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, progressive tubulointerstitial injury remains a major determinant of renal function decline in diabetic kidney disease (DKD), and the molecul...

Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development

This study aimed to integrate in vitro dissolution testing, in vivo pharmacokinetic (PK) studies, and computational simulation to develop a physiologically based biopharmaceutics model (PBBM) for fixed-dose combination ibuprofen/diphenhydramine citrate tablets, thereby evaluating...