Second Affiliated Hospital of Anhui Medical University

Multi-label arrhythmia classification from Holter scatter plots using deep learning and clinically oriented thresholds

Abstract Automated analysis of long-term Holter recordings is important for efficient arrhythmia screening, but most deep learning approaches rely on raw electrocardiographic waveforms. Heart-rate scatter plots provide a compact visual representation of rhythm dynamics and may su...

Association Between Interlimb Asymmetry in Normalized Vastus Medialis sEMG Amplitude and Functional Mobility in Patients with Post-Traumatic Knee Contracture: A Cross-Sectional Study

Background/Objectives: Patients with post-traumatic knee contracture often present with limited range of motion (ROM) and impaired functional mobility, but functional performance may not be fully explained by ROM and pain alone. This study aimed to examine whether normalized vast...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Diagnostic Utility of Complete Blood Count Indices in Ferritin‐Defined Microcytosis Among United States Women Aged 18–49 Years

ABSTRACT Introduction Complete blood count (CBC) discrimination indices are widely used as low‐cost triage tools for microcytosis, but their diagnostic utility in population‐based samples with ferritin‐defined iron status is uncertain. We evaluated whether commonly used indices d...

A Kinetic Originof Vps34-IN-3 Selectivityfor VPS34 over PI3Kα Revealed by Supervised Molecular Dynamicsand Potential of Mean Force Analysis

Abstract The rational design of selective kinase inhibitors is hampered by the conserved ATP-binding pockets. Vps34-IN-3, a potent VPS34 inhibitor developed by Genentech, Inc., showed ∼95-fold selectivity over the closely related PI3Kα, yet the atomic-level mechanism underlying t...

Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus

Objectives Systemic lupus erythematosus (SLE) is a major autoimmune disease. Recent studies have found that changes in lipid metabolism and gut microbes are associated with the pathogenesis of SLE. However, the coordination of gut commensal bacteria and SLE lipid metabolism is no...

Adipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma

Multiple myeloma (MM) remains an incurable blood cancer. Obesity is a known risk factor, but how adipocytes promote MM progression is not fully understood. Here, we uncover a metabolic crosstalk between adipocytes and MM cells that promotes MM cell survival under glucose deprivat...

The endothelial activation and stress index (EASIX) as a prognostic predictor in aggressive B-cell lymphoma

Aggressive B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma, with a generally poor prognosis. This study aimed to evaluate the prognostic value of the endothelial activation and stress index (EASIX) score in patients with newly diagnosed aggressive B-cell lympho...

Prenatal exposure to metal mixtures and newborn birth size in an industrial city: Evidence from cord blood metabolomics

Background Prenatal exposure to metal mixtures may influence newborn birth size, but the underlying metabolic mechanisms remain unclear. This study aimed to evaluate the associations of 19 individual maternal metals and metal mixtures during pregnancy with birth size indicators,...

CTC-AttnNet: development and validation of an attention-based neural network for staging gastrointestinal malignancies

To develop and validate a noninvasive model for classifying T stage in gastrointestinal malignancies using circulating tumor cells (CTCs) and serum tumor markers and to compare the predictive value of CTCs with that of conventional tumor markers. This retrospective study included...