Sechenov University

The impact of the World War I (1914—1918) on evolution of transfusion medicine

The knowledge of transfusion therapy that existed in medicine by the beginning of the First World War formed the foundation of transfusion medicine in the 19th century. These knowledges were further expanded in the early years of the 20th century with immunological characteristic...

In vitro evaluation of pH, calcium ion release and interfacial characterization of calcium silicate–based and epoxy resin–based sealers

Abstract This in vitro study evaluated the physicochemical properties and interfacial behavior of four calcium silicate–based sealers (CSBS) compared to an epoxy resin–based sealer. Specimens were prepared under standardized conditions, and pH and calcium (Ca 2+ ) ion release wer...

Approaches to the Development and Quality Control of Vaccine for Allergen-Specific Immunotherapy of Ragweed Pollen Allergy

Ragweed (Ambrosia artemisiifolia) pollen allergy is a major and growing public health problem worldwide, with clinical manifestations ranging from rhinitis and conjunctivitis to asthmatic episodes and anaphylaxis. The major ragweed allergen, Amb a 1, exhibits high IgE-binding pot...

Resolution of the Expert Council “Non-steroidal anti-inflammatory drugs in the treatment of non-specific back pain and radiculopathy in the 2026 RASP guidelines”

In June 2025, an Expert Council of the Russian Association for the Study of Pain (RASP) was held. Specialists discussed the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of nonspecific (musculoskeletal) lower back pain. The meeting presented data from stu...

Time to pacemaker insertion in older adults: A perspective on mortality and functional outcomes

Pacemaker insertion is common in older adults, yet the implications of procedural delays remain unclear. Nguyen and colleagues reported that longer time to implantation was associated with increased mortality over nearly five years. While this contribution is valuable, several me...

When Personalization Does Not Change Care: A Critical Narrative Review and an Organizational Decoupling Framework

Background/Objectives: Patient-centred practices do not by themselves show whether an individual’s priorities influence care. This review asks how organizational decoupling theory can inform a traceable response to those priorities and locate a loss of influence. Methods: A theor...

Re-Evaluating Multi-Kinase Inhibitors Targeting FGFR and VEGFR Pathways for Combined Therapy in Colorectal Cancer: A Preclinical Study

Background: Overexpression and increased activity of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1/P-gp), breast cancer resistance protein (ABCG2/BCRP), and multidrug resistance-associated proteins (ABCC/MRPs), are known to be among the major contributors...

Indications and Contraindications for Minimally Invasive Rib Remodeling

Background: A narrow waist is one of the central objectives of esthetic body contouring, and it is closely tied to the waist-to-hip ratio that observers associate with a feminine silhouette. Conventional soft-tissue techniques such as liposuction and liposculpture are constrained...

Predicting the Unpredictable: Development and External Validation of the GO SOAR Surgical Risk Calculator for Data-Driven Predictions of Surgical Complications in Gynaecological Oncology Surgery

Background/Objectives: Universal surgical risk calculators are not validated for use and poorly predict postoperative morbidity and mortality for women undergoing gynaecological oncology surgery. This adversely affects communication of risk resulting in poorly informed decisions...

Walking difficulty as a marker of high health need and education-related healthcare response in older adults: a cross-national multicohort study

Health systems need simple ways to identify older adults with high health need and to assess whether healthcare response is distributed according to need rather than social position. Walking difficulty is inexpensive to ascertain and widely harmonisable across ageing cohorts, but...

Auricular autologous cartilage in redo rhinoseptoplasty

Objective. To analyze techniques and indications for redo rhinoseptoplasty with auricular autologous cartilage. Material and methods. The authors analyzed 39 articles containing retrospective and prospective data on outcomes, descriptions and complications of autologous cartilage...

Management of metastatic spinal disease in low- and middle-income countries: an international survey of practices and challenges in Latin America

Spinal metastases impose urgent diagnostic and therapeutic demands; however, evidence from low- and middle-income countries (LMICs) in Latin America is sparse. We aimed to characterize real-world practices, access gaps, and priorities to in-form context-adapted guidelines. We con...

Anatomical features and hemodynamic aspects of vascular anastomoses in reconstructive cardiovascular surgery

Objective. To determine the anatomically optimal configuration and hemodynamic parameters of various types of vascular anastomoses by numerical simulation to ensure long-term patency. Material and methods. Numerical modeling of blood flow in three types of anastomoses was perform...

Efficacy of Potassium-Competitive Acid Blockers Versus Proton Pump Inhibitors in Eradication Regimens for Clarithromycin-Resistant Helicobacter pylori: A Systematic Review and Meta-Analysis

Background: Clarithromycin resistance represents the primary obstacle to the success of conventional proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori (H. pylori) eradication. Potassium-competitive acid blockers (P-CABs) offer faster and more potent acid su...

Neural Network-Based System for Rapid Diagnostic Decision Support Using FLIM Data: Segmentation and Classification in Liver, Skin, and Pancreatic Tissues

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool for analyzing metabolic changes by measuring the fluorescence lifetime of endogenous fluorophores such as the reduced form of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H), enabling differentiation betwe...

Vasorelaxant Effects of Wild Jujube Leaf Aqueous Extract: Endothelial NO/cGMP/SERCA Signaling, Antioxidant Activity, and AI-Based Molecular Docking

Ziziphus lotus (L.) Lam (wild jujube) leaves are traditionally used in Moroccan medicine to treat hypertension. The present study evaluated the aqueous extract of Z. lotus leaves (ZLAqExt) for its vasorelaxant effects, mechanisms of action, acute toxicity, antioxidant potential,...

Muscle Dysfunction as the Missing Link in Ventral Hernia Pathogenesis: Toward a Functional Herniology Framework

This study aimed to perform a conceptual analytical synthesis of the available evidence on the functional state of the musculofascial system of the anterior abdominal wall in ventral hernia, to appraise the potential contribution of muscular dysfunction and neuromuscular discoord...

Protein Variability Patterns in Ovarian Serous Carcinoma

Protein variability patterns in cancer reflects both technical variation and biological heterogeneity and may provide information beyond mean abundance changes. We analyzed protein-level coefficients of variation across four ovarian cancer proteomic datasets, comparing controls a...

Quantum Dot Bioconjugates Enable Order(s)-of-Magnitude Enhancement of Immunoglobulin E Detection Sensitivity

Abstract Improving the sensitivity of immunoglobulin E (IgE) detection is crucial because the concentrations of allergen-specific IgE antibodies are often very low, particularly at early sensitization stages or in patients with weak immune responses. Bright, photostable detection...

The influence of physical, respiratory, and vocal exercises on the acoustic characteristics of the voice of professional vocalists

The article examines the impact of functional tests on the acoustic characteristics of professional singers. Particular attention is paid to an objective analysis of changes in the main acoustic parameters before and after performing exercises. OBJECTIVE: To identify and characte...