Sechenov University

IgG4-related lesion of the retroperitoneum, ureter, and kidney, mimicking infiltrating endometriosis

Urinary tract endometriosis is rare, and ureteral involvement is particularly insidious due to its asymptomatic nature. The absence of symptoms can lead to ureteral stricture, hydronephrosis, chronic kidney disease up to end-stage renal failure, and irreversible loss of kidney fu...

Amino Acid Profiles in Dried Blood Spots and Clinical Outcomes in Selective Fetal Growth Restriction: A Twin-Pair Study

Selective fetal growth restriction (sFGR) remains a leading cause of perinatal morbidity in multiple pregnancies; however, its pathogenesis is not yet fully elucidated. Investigating amino acid metabolism in weight-discordant twins may uncover critical metabolic pathways involved...

Postprocessing of Structural En Face OCT Images of the Choroidal Haller Layer for Quantitative Assessment: An Exploratory Pilot Study

Background/Objectives: To develop a binarization workflow for structural en face OCT images of the choroidal Haller layer and examine how postprocessing parameters affect measurements, using chronological age as an exploratory reference. Methods: We included 66 healthy volunteers...

Thermal Phase Behavior of PNIPAM-Based Hydrogels: Different Scenarios and Implications in Injectable Hydrogel Design

Poly(N-isopropylacrylamide) (PNIPAM)-based hydrogels are “smart” materials of great interest and demand, primarily in a variety of biomedical applications, due to their LCST close to physiological temperature. The basic biomedical applications of PNIPAM-based injectable hydrogels...

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

Background: Growing evidence supports a bidirectional relationship between ‘emotional’ (psychological) stress and intestinal inflammation. ‘Emotional stress’, a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk...

Neutralizing Activity of Vaccine-Induced Antibodies Against Vaccine-Derived Polioviruses Type 2

Background: Nowadays, poliomyelitis caused by wild polioviruses (PVs) has been virtually eradicated. However, since the removal of the type 2 component from the oral polio vaccine (OPV), immunity to PV2 has declined despite expansion of the use of the inactivated polio vaccine (I...

Cdc42 in Tumor Hypoxia: Molecular Mechanisms of Cellular Adaptation

Tumor hypoxia is a hallmark of solid tumors that promotes aggressiveness and resistance to therapy. Within hypoxic tumors, hypoxia-inducible factor (HIF)-dependent transcriptional programs drive metabolic reprogramming, lactate accumulation, extracellular acidosis, angiogenesis,...

New perspectives in phenotyping and endotyping of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition and a leading cause of morbidity and mortality worldwide. COPD represents a constellation of distinct etiotypes, clinical phenotypes, and pathogenetic endotypes, which necessitates a shift toward personaliz...

Provision of biologic therapy for severe asthma and chronic obstructive pulmonary disease: an analysis of data from 51 regions of the Russian Federation

Objective. To assess the actual coverage of biologic therapy in patients with asthma and chronic obstructive pulmonary disease (COPD), the structure of its funding channels and between-region variability of provision, and to compare two independent data sources on biologic use. M...

The effect of enhanced external contrpulsation on the diaphragm mobility and power of the patient with a combination of bronchial asthma and chronic obstructive pulmonary disease

Respiratory muscle weakness is an important factor aggravating pulmonary dysfunction and reducing quality of life in patients with chronic lung diseases. Objective. To evaluate the efficacy of enhanced external counterpulsation as an additional non-pharmacological method aimed at...

Chronic bronchitis in outpatient practice: unsolved diagnostic problems and therapeutic challenges

Chronic non-obstructive bronchitis (CB) represents an independent clinical condition characterized by high prevalence and a considerable contribution to respiratory morbidity, alongside a significant economic burden. Despite its seemingly benign nature, the management of patients...

Mass-momentum synergistic transport criterion in gravity-controlled closed phase-change systems: Numerical validation using nanofluid-enhanced heat pipes

In closed phase-change heat transfer system under gravitational control, the essence of coordinating the material basis (mass source) and the driving potential (momentum source) to maintain efficient circulation dynamics lies in the fact that the geometric topology of the liquid...

Asymmetric Metal-Templated Synthesis of Congested Proline Derivatives via [3 + 2] Cycloaddition Reaction

Abstract An asymmetric synthesis of congested proline derivatives with three defined carbon stereocenters (including two quaternary ones) through an Ag(I)-catalyzed [3 + 2] cycloaddition reaction is described. The atom-economic coupling of a chiral dehydroalanine Ni(II) complex w...

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptos...

Macrophage Density Patterns in Uterine Leiomyomas Across Patient Age Groups: Evaluation of Separately Quantified CD68-Positive and CD163-Positive Cells

Tumor-associated macrophages (TAMs), key effectors of the innate immune system, actively participate in extracellular matrix remodeling, angiogenesis, and tumor growth. However, their age-associated quantitative and phenotypic distribution in uterine leiomyoma microenvironment re...

Vaginal formulations selectively target Lactobacillus iners and Candida spp. while preserving Lactobacillus crispatus

Vaginal eubiosis is associated with low bacterial diversity and Lactobacillus crispatus dominance, whereas Lactobacillus iners often persists after antibiotics. We evaluated complementary approaches to inhibit L. iners and Candida spp. while preserving L. crispatus . Carbohydrate...

Cellular and Tissue Mechanisms of Laser-Assisted Regeneration of Tympanic Membrane Perforation

Chronic tympanic membrane (TM) perforations remain a significant clinical problem due to limited spontaneous healing and the drawbacks of surgical interventions. The present study aimed to evaluate the effects of low-intensity infrared laser irradiation on cellular mechanisms of...

Escherichia coli -derived enterobactin is associated with delayed gut microbiome maturation in infants born to mothers with obesity

ABSTRACT Maternal obesity has been increasingly recognized as a factor influencing early-life microbiome development. However, its impact on the infant gut resistome and virulome remains insufficiently characterized. In this prospective longitudinal study, we investigated gut mic...

Surgical treatment of advanced age patients with bilateral carotid artery disease

Objective. To analyze the effectiveness of surgical treatment in elderly patients with bilateral atherosclerotic lesions of carotid arteries. Material and methods. Carotid endarterectomy was performed in 91 patients aged 75—90 years (62 men, 29 women; mean age 78±2 years) with bi...

Composite homograft in a pediatric patient with prosthetic aortic valve endocarditis

A composite aortic homograft was used in a 14-year-old patient with prosthetic aortic valve endocarditis. There were severe prosthesis-patient mismatch and active infection confirmed by Staphylococcus aureus isolation. Redo surgery implied removal of infected prosthesis, debridem...