Sechenov University

Siteomix: a PyMOL plugin for the detection, alignment, and similarity analysis of protein‒ligand binding sites

The analysis of structural similarity among protein active sites is fundamental to understanding functional relationships between proteins and plays a critical role in structure-based drug design. Detailed characterization of protein‒ligand binding site similarity requires not on...

Thematic Structure of Clinical Rehabilitation Research in the Early Post-Pandemic Period: An LDA-Based Analysis of Publications from 2022 to 2025

Background/Objective: Recent advances in scientometric topic modeling have enhanced the capacity to rapidly assess evolving research priorities. This study aimed to characterize the thematic reorganization of clinical rehabilitation research during the early post-pandemic period...

High-Ratio Partial Proteolysis with Carrier Proteome (HOLSER) Enables Global Structure Profiling and Site-Resolved Elucidation of Ligand-Protein Interactions.

Understanding how cellular proteins interact with their environment, including endogenous and exogenous molecules, is critical for elucidating mechanisms of cellular regulation and drug action. Partial proteolysis-based techniques offer peptide-level resolution of ligand-induced...

Nanoindentation in the assessment of biomechanical parameters of extraocular muscles

This article describes a technique for biomechanical testing of human extraocular muscle samples based on the principle of nanoindentation. The technique involves both static and dynamic testing of tissue samples. The study determines a set of biomechanical parameters that charac...

Bad Blood: Navigating VTE Risk in Breast, Ovarian, and Endometrial Cancer

Cancer-associated thrombosis (CAT) is defined as venous or arterial thrombotic events occurring in patients with active malignancy or during anticancer treatment, most commonly presenting as venous thromboembolism and representing a leading cause of morbidity and mortality in onc...

Does increased staging complexity influence expert agreement in dental age estimation?

Dental age estimation (DAE) is a well-established procedure in current practice, and it is frequently required in forensic and legal investigations. This study aimed to evaluate the intra- and inter-observer reliability of dental development staging among forensic practitioners u...

Non-Random Association of Ultraconserved Genomic Elements (UCE) with Human Genes

Ultraconserved elements (UCEs) are among the most evolutionarily conserved DNA sequences in vertebrate genomes, yet the biological mechanisms underlying their extraordinary conservation remain poorly understood. Using the recently developed dedUCE database comprising 12,813 human...

Electrospun Nanofibers Loaded with Verbena officinalis Extract as Multifunctional Bioactive Wound Dressings

Background/Objectives: Verbena officinalis has long been used in traditional medicine for treating skin disorders, yet its potential in advanced wound-dressing systems remains insufficiently explored. This study aimed to characterize V. officinalis extracts obtained using differe...

The janus-faced function of mesenchymal stem cells in oral cancer

Mesenchymal stem cells (MSCs), which exist in bone marrow, tooth pulp, and tumor microenvironments, have a dual role in oral malignancies. These cells interact closely with cancer stem cells (CSCs) and the tumor microenvironment (TME). On the one hand, MSCs accelerate the growth...

Photo-Responsive In Situ Forming Hydrogels for Drug Delivery: A Critical Review of Polymer Matrices, Photoinitiators, and the Gap Towards Clinical Translation

Local drug delivery increasingly relies on injectable hydrogels that form directly at the x‘administration site, among which light-cured systems are of particular interest: irradiation converts a liquid precursor into a depot and can trigger drug release with high spatiotemporal...

Dental caries experience in first permanent molars and its associated factors among Iranian primary school-aged children: a cross-sectional study

Abstract Background Dental caries in first permanent molars is a highly prevalent condition in primary school-aged children and represents a substantial oral health burden in Iran. This study aimed to assess dental caries experience, based on the decayed, missing, and filled teet...

Results of the meeting of the Interdisciplinary Expert Council on an integrated approach to the management of peri- and postmenopausal women with psycho-emotional and neurological disorders

The reduction in sex hormone levels during the menopausal period substantially impacts patients' quality of life and serves as a significant risk factor for psycho-emotional disorders. Current clinical guidelines from both Russian and international sources recognize menopausal ho...

Prevalence of mental disorders and syndromic mental distress in patients with chronic dermatoses: A cross-sectional epidemiological study

Objective. To evaluate the prevalence and clinical structure of comorbid mental disorders among patients with chronic dermatoses, to identify associations with specific nosological forms of skin diseases, and to perform a differential analysis of subsyndromal mental distress. Mat...

Medical students' health changes during their studies at the medical university

Investigating the health status of medical students, along with the factors that influence it, is essential for developing and evaluating preventive measures and health promotion initiatives within higher medical education institutions. Objective. To describe the medical and soci...

From Oncolysis to Adaptive Immunity: Yellow Fever Virus 17D and Ruxolitinib Activate Antitumor Immune Responses in Pancreatic Cancer Models

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, with a five-year survival rate of less than 12%. Oncolytic viruses are considered a promising immunotherapeutic approach, but their effectiveness is often limited by the innate interferon...

Specific features of arterial hypertension in various metabolic phenotypes of obesity

The adipose tissue, selectively affecting the metabolic profile, forms various phenotypes of metabolic health. The excess visceral fat can form both favorable metabolic phenotypes and unfavorable ones – associated pathogenically with arterial hypertension. This study is aimed at...

Beyond majority voting: a new framework for evaluating AI diagnostic systems against expert consensus

The integration of artificial intelligence (AI) into medical diagnostic workflows requires robust and consistent evaluation methods to ensure reliability, clinical relevance, and the inherent variability in expert judgments. Traditional metrics like precision and recall often fai...

The Effect of Low-Intensity Laser Irradiation on GAP-43 Expression in the Hippocampus of Rats

A study was conducted to examine the effects of visible red light phototherapy with a wavelength of 635 nm on the expression of the neuronal protein GAP-43 in the hippocampus of rats. It was shown that the use of PBMT promotes increased GAP-43 synthesis in the hippocampus, with t...

Results of the meeting of the Interdisciplinary Expert Council on an integrated approach to the management of peri- and postmenopausal women with psycho-emotional and neurological disorders

The reduction in sex hormone levels during the menopausal period substantially impacts patients’ quality of life and serves as a significant risk factor for psycho-emotional disorders. Current clinical guidelines from both Russian and international sources recognize menopausal ho...