Scuola Superiore Sant'Anna

Exercise and Thoracic Aortic Aneurysms: A Paradigm Shift Toward Informed, Personalized Activity Guidelines

Exercise is widely recognized for its cardiovascular benefits; however, its safety and role in patients with thoracic aortic aneurysms (TAAs) remains complex due to its distinctive biomechanical vulnerabilities. Fundamentally different from abdominal aortic aneurysms, TAAs develo...

From Photosynthesis to Polyphenols: Caffeine Enhances Fruit Quality, Ripening, and Secondary Metabolism in Olive (Olea europaea L.) cv. ‘Leccino’

Despite growing interest in caffeine as a potential plant biostimulant, its effects on perennial crops such as olive remain poorly understood. This study investigated the effects of low-dose caffeine application on leaf gas exchange and photosynthetic activity, fruit ripening, an...

There are different shades of green: heterogeneous environmental innovations and their effects on firm performance

While an established literature highlights the variety of firms' eco-innovation strategies, systematic evidence on the heterogeneous effects of different environmental innovations on different dimensions of firm performance is lacking. This study contributes to filling this resea...

Drug shortages in Italy: strategic insights and empirical evidence from the Italian pharmaceutical market

Abstract Drug shortages disrupt healthcare delivery and pose a critical challenge to the resilience of pharmaceutical supply chains. This study investigates the drivers of drug shortages in Italy – Europe’s leading pharmaceutical producer – to identify the factors associated with...

Azospirillum–Methylobacterium Inoculation Enhances Olive Growth and Reshapes Root Exudate Chemistry: A Preliminary TD-GC-MS Characterization

Abstract Plant growth–promoting bacteria (PGPB) are increasingly applied to perennial crops, yet their chemical footprints at the root–soil interface remain poorly investigated in species such as olive. In the present study, greenhouse-grown plants of Olea europaea L. cv. Leccino...

Cell-type-specific mechanoadaptation to sustained hydrostatic pressure and flow in glioblastoma cells and astrocytes

Abstract Mechanical forces are increasingly recognized as regulators of cellular behavior, yet their impact on glioblastoma cells and astrocytes remains incompletely understood. Here, we investigated the effects of fluid flow and hydrostatic pressure (HP) on human glioblastoma U8...

Beyond optimisation: Revisiting energy demand management

Energy demand reduction (EDR) in households has re-emerged as a central pillar of climate and energy transition strategies in Europe and beyond. While energy efficiency has long dominated policy frameworks, growing evidence shows that efficiency alone is insufficient to achieve a...

Digital Populism and EU Regulatory Responses: An Ecosystem Analysis

Abstract A novel form of populism has emerged from the power of online platforms and the piecemeal regulation of the internet; it is digital in nature. Populist leaders have exploited the opportunities afforded by social media platforms to enlarge their audience. The digital mani...

Learning-Based Methods and the Future of Numerical Ocean and Sea-Ice Modeling

The field of operational oceanography is undergoing a significant evolution with the increasing integration of artificial intelligence (AI) methods, which are complementing and, in some cases, redefining traditional numerical modeling approaches. This review explores how AI metho...

On and off the podium: long-term impact evaluation of European R&D Grants on patenting performance

Abstract This study evaluates the impact of the European SME Instrument (SMEi) on patent performance and technological specialization in small and medium-sized enterprises (SMEs). More specifically, using data from Phase 2 of the European program (2014–2018), we compare SMEs that...

How Organizations Evaluate Eco‐Innovation Investability: A Managerial Cognition Perspective

ABSTRACT Eco‐innovation is widely recognized as a key mechanism through which firms pursue sustainability objectives. However, little is known about the microfoundations through which specific eco‐innovation initiatives secure internal investment support within organizations. Dra...

Integrated Phenolic, Volatilomic and Sensory Profiling of Two Finger Lime Cultivars and Faustrime Grown in a Mediterranean Region

Finger lime (Citrus australasica) is an Australian native citrus valued as a “citrus caviar” in high-end gastronomy, and its cultivation is expanding in the Mediterranean region. Comparative quality data for different genotypes grown under Italian conditions are still scarce. Thi...

Space Medicine and cardiovascular mathematical-computational simulation: Applications of Navier-Stokes Solutions to Astronaut Cardiovascular Systems

Prolonged human exposure to microgravity precipitates severe cardiovascular deconditioning driven by the elimination of hydrostatic pressure gradients. Gravitational unloading triggers an immediate cephalad fluid shift, progressive myocardial atrophy, spaceflight-associated neuro...

Modelling and characterization of the unzipping dynamics of dielectric fluid actuators

Dielectric Fluid Actuators (DFAs) are variable capacitors that contract as a result of electrostatic forces acting on a compliant multilayer structure composed of a polymer film and an insulating liquid. Differences in the dielectric time constants of the liquid and polymeric lay...

Treatment and Outcomes of Kawasaki Disease Over 40 Years

BACKGROUND Kawasaki disease (KD) is the leading cause of acquired heart disease in children in developed countries. Long-term prognosis depends on coronary sequelae, yet Western longitudinal data integrating acute-phase features, treatment, and long-term coronary outcomes remain...

Advanced Mathematical Models, Biomathematics and Spatial Bioinformatics for the Discovery of Novel Therapeutic Targets

Rational therapeutic target discovery and systems biology face a decisive epistemological challenge: the fragmentation between the kinetic dynamics of intracellular pathways and the spatial-geometric complexity of macromolecular interactions. This work outlines an integrated anal...

The carbon content of billionaire wealth: composition, concentration and taxation

Abstract How large are billionaires' carbon footprints? While increasing evidence highlights large disparities in emissions between and within countries, detailed individual‐level data on emissions portfolios remain scarce. In this paper, we analyse the wealth composition of the...

Osseoperceptive EMG Feedback Improves Grasp Force Control in Myoelectric Prosthetic Hands

Restoring sensory feedback is essential for achieving accurate and natural control of myoelectric prosthetic hands, yet most clinical systems remain open loop. Osseoperception, the transmission of vibrotactile and auditory sensations through bone-conducted mechanical stimulation,...

Physical and Mathematical Modeling of the Cardiovascular System: An Overview of Aortic Hemodynamics, 3D Heart Simulation, and Fluid-Structure Interaction

A comprehensive overview of cardiovascular mathematics, a multidisciplinary field at the intersection of biomedical engineering, fluid dynamics, and computational mechanics is provided for analyzing multicomplex systems of blood circulation and the cardiovascular system. By trans...

Pain Matters? The New Life of Poena Naturalis

Abstract What purpose does legal punishment serve when the offender is already enduring profound suffering as a consequence of the offence itself? This paper addresses that question through the concept of poena naturalis: the severe suffering that may result from a grave misfortu...