Sarah Cannon

Codex: Planetary Adaptation and Human Sustainability Beyond Earth

Abstract Human existence is deeply tied to Earth’s environment—oxygen-rich air, stable gravity, and a biosphere optimized over millions of years. Yet the future of civilization demands expansion beyond Earth, into planets such as Mars and the Moon, which lack the fundamental cond...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...