San Francisco VA Health Care System

β3‑adrenergic receptor agonist improves recovery after volumetric muscle loss and is associated with increased intramuscular brown/beige adipogenic activity in mice

Abstract Background Volumetric muscle loss (VML) often results in chronic muscle weakness, limb dysfunction, and even permanent disability. Current research primarily focuses on cell and extracellular matrix transplantation, but there is a lack of studies on the physiologically s...

Designing for access: implementation determinants of harm reduction vending machines in veterans supportive housing

Abstract Background Harm reduction vending machines (HRVMs) are an emerging strategy to provide convenient, low-threshold access to harm reduction and other health-related supplies, yet evidence and practical guidance on implementation, particularly in supportive housing and for...

Functional seizures: care experiences of U.S. Veterans and their care partners

Functional seizures (FS) present substantial diagnostic and treatment challenges, particularly for Veterans with multiple medical and psychiatric comorbidities including post traumatic stress disorder, mood disorders and traumatic brain injury. To more effectively care for Vetera...

Harm Reduction Vending Machines in Supportive Housing for Veterans

Importance Harm reduction vending machines (HRVMs) are an evidence-based strategy to provide low-barrier access to harm reduction and health supplies; however, little is known about their perceived impacts in permanent supportive housing for US veterans. Objective To evaluate vet...

Perceptions of Incidental Findings on Lung Cancer Screening Exams: A National Survey of Primary Care Clinicians and Radiologists

RATIONALE: Unlike other common cancer screenings, annual lung cancer screening often identifies a spectrum of incidental findings unrelated to lung cancer. While these findings could be actionable, how to best communicate and manage them can be a challenge, often falling upon pri...

Community-Based Surgery and Postoperative Survival Among Veterans Affairs Enrollees

Importance: The Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks (VA MISSION) Act of 2018 greatly expanded Veterans Affairs (VA) enrollees' access to non-VA (community care) services. Since then, community-based utilization has increased...

Heterogeneous human muscle fibroadipogenic progenitors include a DLK1 + subpopulation that prevents fatty infiltration after injury

Fatty infiltration and fibrosis drive poor outcomes after chronic muscle injury. Here, we characterized fibroadipogenic progenitor cell (FAP) subpopulations from healthy and injured human rotator cuff muscle by single-cell RNA sequencing, full-spectrum flow cytometry, and functio...

Centering Veteran expertise: advancing peer-led harm reduction in the Veterans health administration

Abstract The principle “Nothing about us without us” underscores the ethical imperative to involve people with lived and living expertise in shaping harm reduction praxis. While the United States Veterans Health Administration (VHA) has expanded harm reduction initiatives, such a...

Phenotypic divergence in rotator cuff tear and volumetric muscle loss mouse models following fibroadipogenic progenitor depletion

Aims: Fibroadipogenic progenitors (FAPs) are a group of resident muscle stem cells capable of differentiating into fibroblasts and adipocytes, contributing to intramuscular fibrotic and fatty degeneration after injury. However, FAPs are also thought to play a crucial role in musc...