Saitama International Medical Center

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by exposure to a traumatic event, which manifests with anguish, intrusive memories, and negative mood changes. So far, there is no efficient treatment for PTSD other than symptomatic palliative care. Howe...

Opioid use, disability, and patient‐reported cognitive impairment in migraine: Multi‐country results from the Chronic Migraine Epidemiology and Outcomes—International Study

OBJECTIVE: To characterize the population who do and do not use opioids to treat migraine in the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study. BACKGROUND: Opioids are not recommended for migraine treatment because of efficacy and safety limitations. ME...

Successful staged anatomic repair for congenitally corrected transposition with both atrioventricular valves’ regurgitation: a case report

Abstract A 4-year-old boy with dextrocardia, congenitally corrected transposition of the great arteries, pulmonary valve stenosis, and ventricular septal defect demonstrated progressive hypoxemia and mild-to-moderate mitral and tricuspid regurgitation. Cardiac magnetic resonance...

From Biological Insight to a New Class of Medicines for Hemophilia A

In this Perspective, the 2026 Lasker-DeBakey Clinical Medical Research Award winners describe the development of a bispecific antibody that mimics blood coagulation factor VIII, revolutionizing the treatment of hemophilia, a life-threatening bleeding disorder caused by lack of fa...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...

Influence of Anatomical Variations due to Horseshoe Kidney on Colorectal Cancer Surgery

BackgroundHorseshoe kidney is a rare renal fusion anomaly often associated with vascular and ureteral variations. Previous case reports have described technical considerations during colectomy in patients with horseshoe kidney. However, studies systematically evaluating the impac...

P1.232. Treatment Outcomes of Conversion Surgery for Advanced Esophageal Cancer Following ICI-Combined Chemotherapy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Immune checkpoint inhibitor (ICI)-based combination chemotherapy for advanced esophageal cancer demonstrates high response rates, enabling conversion surgery in some cases. H...

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC). H...

Accurate Diagnosis of Atrioventricular Nodal Reentrant Tachycardia With Very Short His‐Atrial Interval and Earliest Activation in the Proximal Coronary Sinus

ABSTRACT Introduction Differential diagnoses in atrioventricular nodal reentrant tachycardia (AVNRT) with His‐atrial (HA) interval of < 70 ms and earliest atrial activation site (EAAS) in the proximal coronary sinus (pCS) include slow‐fast AVNRT with inferior deviation of the...