Royal Prince Alfred Hospital

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Acute Effects of Impella 5.5 on Biventricular Filling and Pressure–Volume Area in Patients With Heart Failure Associated Cardiogenic Shock

Use of Impella 5.5 in patients with decompensated heart failure-associated cardiogenic shock (ADHF-CS) is increasing as a bridge to advanced therapies. The effects of maximal trans-valvular unloading on biventricular filling and pressure–volume area (PVA) in ADHF-CS are poorly un...

Free Mucosal Grafting Is a Simple Adjunct for Rapid Re‐Epithelization in Septal Perforation Repair

ABSTRACT Objective Mucosal grafting has become more established in rhinology. While it is accepted that free mucosal grafts take to bone and vascularized recipient beds, the use of mucosal grafting on the contralateral side during nasal septal perforation (NSP) repair with vascul...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Patient perspectives on cardioprotective medication during breast cancer treatment

Cardiotoxicity remains a key concern of HER2-directed therapies, with no proven prevention strategies. The success of cardioprotective interventions will depend not only on efficacy, but on patient acceptability, an underexplored determinant of trial participation and clinical im...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Evaluation of 18 S rRNA as an endogenous control in OpenArray® plasma RNA qPCR workflows

Abstract Background Reliable qPCR analysis depends on stable endogenous controls, particularly in high-throughput pre-amplification workflows where technical bias may arise. The suitability of highly abundant 18 S rRNA as a reference gene in multiplex OpenArray ® platforms remain...

Evaluating the use, acceptability, usability, and perceptions of melanoma risk prediction tools for estimating melanoma risk among the community and patients in Australia: a mixed methods study

Abstract Background To identify high-risk individuals, melanoma risk prediction tools have been developed. However, little is known about their use in practice by patients and the community. We assessed the use, usability and acceptability of two validated melanoma risk predictio...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

A Silent Killer in an Unlikely Place: Necrotizing Fasciitis of the Breast

Background: Primary necrotizing fasciitis (NF) of the breast is a rare, life-threatening soft tissue infection that is frequently misdiagnosed due to its non-specific early presentation and uncommon anatomical location. Objective: We report a case of primary NF of the breast to h...

Health‐Related Quality of Life in Adults With Congenital Heart Disease: A Population‐Based Study

Background As survival into adulthood improves for patients with congenital heart disease (CHD), quality of that survival is paramount. We assessed health‐related quality of life (HRQL) in a large adult CHD cohort. Methods We studied 868 participants from a multicenter registry w...

Survival among patients with systemic sclerosis‐associated pulmonary arterial hypertension in the Australian scleroderma cohort study

BACKGROUND AND AIMS: Systemic sclerosis (scleroderma; SSc) patients can develop pulmonary arterial hypertension (PAH), which is a leading cause of death. We sought to evaluate severity, therapeutic strategy and survival of SSc-PAH in the Australian Scleroderma Cohort Study (ASCS)...

Indices of obesity, malnutrition and inflammation are strong predictors of mortality in adults with type 2 diabetes: the FIELD study

Abstract Aims/hypothesis Metabolic risk in type 2 diabetes is not fully captured by standard clinical measures. Use of NMR-based metabolomic indices may enhance risk prediction, but their role in individuals with type 2 diabetes is unresolved. Methods We analysed data from 9550 a...

Long‐Term Health‐Related Quality of Life After Jaw Reconstruction With Fibula Free Flaps Using Primary Endosseous Implants and Buried Skin Grafts to Facilitate Implant‐Retained Dental Prostheses

ABSTRACT Background Data on health‐related quality‐of‐life (HRQoL) is indispensable in understanding patient outcomes following jaw reconstruction. This study aims to evaluate long‐term HRQoL using validated patient‐reported outcome measures (PROMs) following jaw reconstruction u...

Implementation and Management of Cancer Clinical Quality Registries in Australia: A Qualitative Study

ABSTRACT Background In Australia, clinical quality registries (CQRs) for cancer care are becoming increasingly common, requiring integration across multiple sectors of the health system. This study sought to identify the means to successful implementation of CQRs in Australia by...

Sodium butyrate rescues long-term neurodevelopmental deficits following perinatal methadone exposure

Abstract Background Prenatal opioid exposure (POE) induces long-term neurodevelopmental, behavioral and cognitive deficits for which no targeted treatments are available. The mechanisms underlying POE deficits are poorly understood, but have been linked to a range of central, per...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Level IA Nodal Involvement in Parotid Cutaneous Squamous Cell Carcinoma

ABSTRACT Background The frequency of Level IA metastasis in advanced cutaneous squamous cell carcinoma (cSCC) remains undefined yet determines the oncological safety of submental island flap (SIF) reconstruction. Methods A retrospective cohort study was performed on 131 adults wh...