Royal Netherlands Academy of Arts and Sciences

Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding

Abstract Genome size varies more than 10,000-fold across eukaryotes, yet how the mitotic spindle adapts to this range remains unknown. Here we show that metaphase plate width scales with genome size following a power law with an exponent of ~1/3 across eukaryotes. Comparative ana...

Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Abstract Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses without affecting the kinematics of the movement. The simple spi...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...