Institution
Rockefeller University
Recent research
- Health & MedicineOpen access
A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors
Abstract The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (...
- Biology
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...
- BiologyOpen access
Corema album is a perennial, dioecious shrub endemic to the Atlantic coast of the Iberian Peninsula and the Azores. It inhabits coastal dune ecosystems from Galicia to the Strait of Gibraltar, where it plays an important ecological role. The goal of this study was to assemble and...
- Society & EconomicsOpen access
The effect of judges’ institutional interests on a free press
Abstract Free press protections are fundamental to constitutional democracy, yet their enforcement varies when judges themselves face media scrutiny. Drawing on 658 decisions from eight democratic countries and the European Court of Human Rights, we show that judges are significa...
- Health & MedicineOpen access
Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...
- BiologyOpen access
We present a genome assembly from an individual male Dermanura phaeotis (Chordata; Mammalia; Chiroptera; Phyllostomidae). The genome sequence is 2.2 Gb in span. The majority of the assembly is scaffolded into 30 chromosomal pseudomolecules, with the X and Y sex chromosomes assemb...
- BiologyOpen access
Abstract In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on...
- BiologyOpen access
Genetic variants in the RNA-binding protein bicaudal C1 (BICC1) have been linked to very-early-onset polycystic kidney disease (PKD). This study identifies a crucial integrin-beta1 (ITGB1)-BICC1-polycystin-1 (PC1) complex that regulates F-actin organization and cell adhesion in h...
- Health & MedicineOpen access
Abstract Chikungunya virus (CHIKV) infection is typically not life-threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0–89 years, n = 245), 20...
- BiologyOpen access
RTF2 and CLASPIN localize CHK1 to the replication fork to control S-phase progression
The essential kinase ataxia telangiectasia and Rad3-related (ATR) monitors the replicative (S) phase of the cell cycle to ensure faithful propagation of genetic material. While much is known about the mechanisms governing ATR activity at replication forks, how its effector checkp...
- Health & MedicineOpen access
The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential
The cGAS/STING pathway is a central innate immune DNA-sensing system that links aberrant DNA species to innate immune and stress-response transcriptional programs and has emerged as a key regulator of tumor-immune interactions. In cancer, pathway outputs are shaped by interconnec...