Institution
RIKEN Center for Sustainable Resource Science
Recent research
- Health & Medicine
Structural and Mechanistic Basis of Bacterial 2-Methyl-ACC Synthases
Abstract Cyclopropane-containing amino acids are found in diverse natural products and contribute to their structural complexity and biological activity. However, the distribution of bacterial biosynthetic pathways that produce methylated cyclopropane amino acids and the structur...
- BiologyOpen access
Patescibacteria, also known as the Candidate Phyla Radiation (CPR), are among the most diverse yet functionally reduced bacterial lineages whose diversity in agricultural soils remains poorly characterized. We applied single-cell genomics to bulk soil from an unfertilized paddy f...
- BiologyOpen access
2-Aminoisobutylic Acid-Stabilized Helical Peptides for Selective Mitochondrial Gene Delivery
Abstract Efficient gene delivery to mitochondria remains a major challenge in the development of organelle-targeted therapeutics. Here, we report the rational design and evaluation of helix stabilized mitochondria-targeting peptides (MTPs) via the incorporation of 2-aminoisobutyr...
- BiologyOpen access
A repurposed pseudoenzyme enables redox- and acetylation-dependent control of CoA transferase
CoA transferases play essential roles in short-chain fatty acid and acyl-CoA metabolism, yet how their activities are regulated in response to metabolic signals remains unclear. Here, we show that a CoA transferase from Thermus thermophilus is controlled by a two-layer mechanism...
- BiologyOpen access
Lsp2 links early-life diet to adult translation and lifespan in Drosophila
Abstract Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia 1,2 . The effect of juvenile diet on adult physiology and lifespan has subsequently been described in other model organisms, including fruit flies 3–5...
- BiologyOpen access
ABSTRACT Microorganisms in nature form communities through diverse interactions, such as mutualism and competition, to adapt to their ecological environments. These interactions seem to be mediated by extracellular metabolites (exometabolites), yet the chemical and biological div...
- Biology
Fusarium oxysporum isolates causing Fusarium wilt in mitsuba (Cryptotaenia japonica Hassk.; also referred to as Japanese honeywort, Japanese honewort, or Japanese parsley) have traditionally been classified as f. sp. apii. However, some reports have indicated that the host-pathog...
- Materials & EnergyOpen access
ABSTRACT The development of a general strategy for accessing structurally diverse nanographenes and polycyclic aromatic hydrocarbons (PAHs) remains a central challenge in synthetic chemistry. Although annulative π‐extension (APEX) enables the direct construction of fused aromatic...
- Materials & Energy
Abstract A catalytic, site-selective silylation and borylation sequence allows the synthesis of unsymmetrically 1,3,5-trisubstituted arenes. A spirobipyridine ligand bearing a “steric roof”, in combination with iridium creates a catalyst that recognizes the shape of a monosubstit...
- Health & MedicineOpen access
Cancer cells maintain chronically elevated levels of reactive oxygen species (ROS) while relying on robust antioxidant programs to preserve redox homeostasis and viability. Although therapeutic strategies that disrupt this balance to induce lethal oxidative stress and ferroptosis...
- Materials & EnergyOpen access
Atomic-precision π-driven peptide hydrogel nanofibers with ordered water channels
Aromatic interactions organize molecules into ordered supramolecular architectures, while peptides form functional soft materials through hydrogen bonding and water-mediated assembly. In peptide-based systems, strong aromatic stacking is typically achieved by terminal capping, wh...