Rigshospitalet

Biologic-assisted house dust mite immunotherapy in allergic asthma: could it provide a bridge toward de-escalation?

To the Editor,We read with great interest the three-year randomized study by Bozek and colleagues comparing omalizumab, subcutaneous house dust mite allergen immunotherapy (HDM-SCIT), their combina...

Growth and Fibrosis in Children With Biliary Atresia: A Retrospective Cohort Study

ABSTRACT Aim To determine growth patterns and catch up potential in children with biliary atresia, in relation to liver disease severity and liver transplantation. Methods This retrospective cohort study was conducted at Copenhagen University Hospital between 1 January 2006 and 3...

Perioperative Use of Vasoactive Agents in Patients Undergoing Gastrointestinal Surgery: A Protocol for a Scoping Review

BACKGROUND: Perioperative hypotension in patients undergoing gastrointestinal surgery is a known and well-described condition. Timely treatment of perioperative hypotension, regardless of the reason, is important in order to reduce the associated postoperative complications. The...

Paired comparison of extrinsic feedback effects on motor learning and functional recovery after stroke: a secondary analysis of randomized controlled trials

Introduction Extrinsic feedback (EF) provides external signals during motor practice to enhance knowledge of performance or results. While EF can improve outcomes after stroke, its relative effects on motor learning versus functional recovery remain unclear.Objective To directly...

A Novel Tool to Create Digital Twin Temporal Bone Models for Virtual and 3D-Printing: Proof-of-Concept and Evaluation

Objective: To develop a haptic software tool for creating digital twin models for virtual or physical interaction based on cone beam (CB) computed tomography (CT) temporal bone imaging and to evaluate the quality of resulting 3D-printed models. Background: Temporal bone surgery i...

Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway

Abstract Recent genetic studies have identified defects in the PIWI-interacting RNA (piRNA) pathway to cause nonobstructive azoospermia. However, limited knowledge of piRNA function in human spermatogenesis makes it difficult to quantify the number of cases affected. Central to t...

Prevalence of hearing loss and tinnitus after childhood cancer treatment: a Danish nationwide registry-based study

Background Despite rising survival rates and high-quality health data available - no large-scale study has mapped the full Danish Childhood Cancer Survivor population with auditory late effects.Aims/objectives This study aimed to estimate the prevalence of auditory late effects a...

Laser interstitial thermal therapy in pediatric neurosurgery: a prospective nationwide study on indications, safety, and early outcomes

Abstract Purpose To evaluate indications, safety, and early outcomes of MRI-guided laser interstitial thermal therapy (LITT) in a nationwide prospective pediatric cohort and to assess the feasibility of same-session stereotactic biopsy. Methods All consecutive pediatric patients...

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024...

Durability of RSV Prefusion F Vaccine Protection across Two RSV Seasons

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death among older adults. Although first-season vaccine effectiveness against RSV-related hospitalization has been demonstrated for the bivalent RSV prefusion F protein-based vaccine (RSVpr...

The historical development of sample size estimation: from Huygens and Bernoulli to the present

This paper traces the historical development of frequentist sample size estimation from its philosophical origins to its present-day complexity. Preliminary concepts were identified by Christiaan Huygens’ work on expected value and Jacob Bernoulli’s law of large numbers , which f...

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

AIMS: Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, c...

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis

BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Lessons from the Danish Vascular (DanVasc) pilot survey: patient-reported outcomes following lower extremity, carotid and aortic artery disease

Patient-reported outcomes are insufficiently studied across the three predominant vascular diseases: lower extremity artery disease (LEAD), symptomatic carotid stenosis (SCS) and abdominal aortic aneurysm (AAA). To address this gap, the Danish Vascular (DanVasc) survey was develo...

Uncovering dynamic human brain phase coherence networks

Abstract Complex cognitive functions rely on coordinated communication between distributed brain regions, yet capturing these interactions as they evolve over time remains challenging. Traditional analyses of functional brain connectivity largely rely on correlations in signal am...

Evaluation of a human slow-release buprenorphine formulation in rats – tactile sensitivity and plasma concentration

Abstract Background Opioids are considered ideal for managing moderate to severe post-operative pain in laboratory rodents, with buprenorphine being one of the most commonly used analgesics in rats. A long-acting buprenorphine formulation would be highly beneficial to avoid frequ...

Error replication as an instructional strategy in simulation‐based procedural learning

Abstract Background Errors are an inevitable part of clinical learning, yet procedural training commonly emphasises error avoidance. This study examined the effect of deliberate replication of predefined procedural errors (Error Replication; ER), compared with error avoidance tra...

Low‐Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle‐Aged and Older Adults: Study Protocol for a Triple‐Blind, Randomised, Placebo‐Controlled Trial

ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and sen...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...