Rigshospitalet

Internet-based Emotion Regulation Individual Therapy for Adolescents (IERITA) plus treatment as usual versus treatment as usual for adolescent outpatients with non-suicidal self-injury—the TEENS multi-site trial: study protocol and statistical analysis plan for a multi-site randomised clinical trial

Non-suicidal self-injury (NSSI) is a public health concern and a widespread behaviour, especially among adolescents. NSSI is an indicator of psychological distress and a known risk factor for later suicidal behaviour and death by suicide; however, evidence-based treatment options...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

P1.158. Clinical Performance of a Liquid Fiducial Marker for Preoperative Marking of the Optimal Resection Line in Gastroesophageal Cancer Surgery

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal and gastroesophageal junction cancers have a poor prognosis despite improvements in curative treatment. Achieving microscopically cancer-free resection margins is essential for long-te...

Inter-Rater Agreement in PD-L1 (22C3) Expression Evaluation in Colon Cancer

Programmed death-ligand 1 (PD-L1) is a predictive biomarker in various cancers. In colorectal cancer, PD-L1 expression evaluation is not part of the routine examination and standardized evaluation methods are lacking. This study aimed to examine inter-rater agreement in PD-L1 exp...

Prognostic Impact of Kidney Function before Transcatheter Aortic Valve Implantation - A Nationwide study

Abstract Background Prognosis after transcatheter aortic valve implantation (TAVI) keeps improving, yet some high-risk groups persist with chronic kidney disease being one. Contemporary data on the prognostic importance of pre-TAVI kidney function are sparse, leaving uncertainty...

Contrast-free super-resolution ultrasound imaging for microvascular assessment of murine subcutaneous tumour models in preclinical oncology

<title>Abstract</title> <bold>Introduction</bold> . Tumour vascularity is an important biomarker of tumour growth and therapeutic response. Current in vivo imaging methods have a limited ability to detect individual tumour vessels due to the small vessel size and low flow rates c...

Current Use, Monitoring and Reversal of Neuromuscular Block in Pediatric Anesthesia and Intensive Care: A Web‐Based Cross‐Sectional ESAIC Survey

BACKGROUND: Neuromuscular blocking agents are recommended by the European Society of Anaesthesiology and Intensive Care (ESAIC) and European Society of Paediatric Anaesthesia (ESPA) for facilitating tracheal intubation in children. Despite these recommendations, real-world data o...

Prevalence, Incidence and Mortality of Chronic Kidney Disease in Type 1 and Type 2 Diabetes—A Nationwide Danish Register‐Based Cohort Study

ABSTRACT Aims Chronic kidney disease (CKD) remains a leading complication of diabetes, and understanding population‐level trends is crucial for prevention and healthcare planning. We examined national trends in CKD prevalence, incidence, and mortality among people with diabetes....

Exercise training during hospitalization in community-acquired pneumonia: effects on functional ability, body composition, and physical activity level

Abstract Background Physical inactivity contributes to functional decline and is associated with increased risk of adverse outcomes in patients hospitalized with community-acquired pneumonia (CAP). Exercise programs applied during acute hospitalization may mitigate these effects,...

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years. The...

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid or...

Associated prognostic impact of opioid use before Transcatheter aortic valve implantation – A Danish nationwide cohort study

Background Opioid use is frequently reported as a baseline characteristic in transcatheter aortic valve implantation (TAVI) cohorts, yet its prognostic implications have not been examined. Aim To examine the association between pre-procedural opioid use and post-TAVI outcomes. Me...

A temporal differentiation program after birth delineates γδ T cell immunity

Type 1 and type 3 γδ T cells develop in the embryonic thymus, yet it is not known whether they continue to differentiate after birth in tissues. Here, we show that in the first week of life, intestinal γδ T cells up-regulated many T cell activation and type 3 genes, while the pos...

Predicting future risk of type 1 and type 2 diabetes after gestational diabetes mellitus using polygenic scores: a cohort study

AIMS/HYPOTHESIS: Women with previous gestational diabetes mellitus (GDM) have an increased risk of developing both type 1 and type 2 diabetes. However, predicting the risk on a personal level is challenging. Polygenic scores (PGSs), which capture an individual's genetic susceptib...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...

Development and validation of a theoretical test for ultrasound-guided biopsy competence in the head and neck

PURPOSE: This prospective study is designed to test the validity of a multiple-choice question (MCQ) test in assessing theoretical knowledge of ultrasound-guided fine-needle aspiration biosy and core-needle biopsy of the head and neck. METHODS: Seven international experts reached...

Risk factors for tuberculosis: a nationwide cohort study among Greenlanders in Denmark, 2005–2022, highlighting social vulnerability

In tuberculosis (TB) low-incidence countries, TB is becoming increasingly concentrated in marginalised populations. Progress towards TB elimination therefore requires targeted interventions informed by knowledge on the determinants of disease in specific subpopulations. In Denmar...