Rega Institute for Medical Research

Uncovering lung virome signatures of COPD severity and acute exacerbations in longitudinally sampled AERIS cohort

Chronic Obstructive Pulmonary Disease (COPD) is increasingly recognized as a complex disorder in which microbial communities may modulate disease progression and exacerbation risk. We investigated the contribution of the respiratory virome to disease severity and acute exacerbati...

Repurposing Thiazole/Benzothiazole-Based Thiazolidinone Derivatives as SARS-CoV-2 Main Protease (Mpro) Inhibitors: An Integrated Computational and Experimental Study

Background/Objectives: SARS-CoV-2, the causative agent of COVID-19, relies on its main protease (Mpro) for viral replication, making this enzyme an attractive target for antiviral drug development. In the present study, we investigated whether a library of previously synthesized...

Five-country analysis of geographic and dietary drivers of gut microbiome composition and genomic variation

Abstract Human diet and lifestyle vary widely across cultures, shaping global diversity in gut microbiome composition and function. However, comparable cross-population studies have been limited by methodological heterogeneity. The Human Diets and Microbiome Initiative (THDMI) in...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Abstract Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus , including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome virus (MERS-CoV), have attracted particular attention due to their re...

Declines in European bumblebee habitat suitability attributable to climate change

Climate change is increasingly implicated in the decline of insect pollinator populations, which provide critical ecosystem services. Isolating its contribution from other co-occurring environmental stresses remains challenging yet crucial for informing conservation strategies an...

The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection

ABSTRACT Background Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented...

Oropouche virus causes severe congenital disease in embryonic mice

Abstract The recent outbreak of Oropouche virus (OROV) in Latin-America with unprecedented reports of vertical transmission resulting in congenital malformations and fetal death, redefines the threat posed by this arbovirus. We discovered that injection of a low inoculum of the e...

Warped Geometries of Segre–Veronese Manifolds

Abstract. Segre–Veronese manifolds are smooth submanifolds of tensors comprising the partially symmetric rank-1 tensors. We investigate a one-parameter family of warped geometries of Segre–Veronese manifolds which includes the standard Euclidean geometry. This parameter controls...