Queen Mary Hospital

Stroke survivors’ health priorities and targeted interventions in home-based post-discharge rehabilitation

<title>Abstract</title> Background This study aimed to describe health problems of the stroke survivors and the corresponding nursing interventions implemented during 12-week home-based post-discharge rehabilitation. Methods This was a descriptive secondary analysis within the co...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Targeting PRMT5 alleviates diabetic cardiomyopathy: mechanisms involve Ndufs2 R118 dimethylation-mediated complex I protection and serum PRMT5 as a biomarker

Abstract Background Diabetic cardiomyopathy (DCM) is defined by progressive cardiac dysfunction driven by myocardial ATP depletion, where mitochondrial electron transport chain (ETC) Complex I dysfunction acts as a critical factor. Protein arginine methyltransferase 5 (PRMT5) mai...

Cost utility analysis of two BK polyomavirus screening strategies: quantitative polymerase chain reaction vs 2-stage approach

Screening for BK polyomavirus (BKPyV) with quantitative polymerase chain reaction (qPCR) or a 2-stage approach with urine cytology followed by qPCR are acceptable strategies. However, the magnitude of the health benefits and incremental cost of adopting these 2 screening strategi...

Healing Following Endoscopic Reconstruction of the Anterior Skull Base in Patients With Sinonasal Malignancies

ABSTRACT Background Healing dynamics after anterior skull base (ASB) reconstruction following transnasal endoscopic surgery (TES) for sinonasal malignancies remain poorly characterized. This study aimed to describe the postoperative healing process, quantify time to healing, iden...

Diagnosis and analysis of plasma phosphorylated tau 217 in a memory clinic cohort: limitations of Generative Pre-trained Transformer-5

INTRODUCTION: No published studies have evaluated the application of Generative Pre-trained Transformer-5 (GPT-5) in the analysis of memory clinic patient clinical notes or the interpretation of plasma phosphorylated tau (P-tau) 217 values. We compared Alzheimer's disease (AD) pr...

Surface selection at the gripping interface for tensile testing per ASTM F2516 affects the pseudoelastic stress-strain response of Nitinol

Complications such as premature failure and sample slippage associated with testing uniform cross-sectioned samples using conventional gripping systems are well known within the testing community. While these complications can be avoided for most materials using dogbone-shaped sa...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...