Queen Mary Hospital

Retrieval of Thrombosed Inferior Vena Cava Filter and Mechanical Thrombectomy of Associated Caval Thrombosis Using FlowTriever and ClotTriever Systems With the ClotTriever as Embolic Protection

A 55-year-old Chinese male with anti-phospholipid syndrome presented with left lower limb deep venous thrombosis (DVT) on warfarin and had an inferior vena cava filter (IVCF) implanted before a radical resection of a perineal sarcoma. The inferior vena cava (IVC) filter removal w...

A territory-wide study on adults hospitalized for rhinovirus infection – mortality, severe adverse respiratory and renal outcomes and relationships with multiple comorbidities

Introduction. While rhinovirus was thought to cause mild infections such as the common cold, severe infections such as community-acquired pneumonia and asthma exacerbations can also occur. Children with chronic medical conditions have been shown to have increased risks of severe...

Maternal and paternal perspectives on breastfeeding knowledge, facilities, and support in Hong Kong

Despite high breastfeeding initiation rates in Hong Kong, duration remains far below World Health Organization recommendations. Although fathers significantly influence breastfeeding choices, few studies have simultaneously evaluated paternal and maternal perspectives on influenc...

Translocator Protein and Mitochondrial Dysfunction in Chronic Kidney Disease

Background: Dysregulation of mitochondrial homeostasis is associated with kidney tubular injury and subsequent tubulointerstitial fibrosis, contributing to the development of chronic kidney diseases (CKD). Translocator protein (TSPO), located on the outer mitochondrial membrane,...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

PROSPECTIVE DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL ON ROBOTIC ARM-ASSISTED VERSUS CONVENTIONAL ONE-STAGE BILATERAL TOTAL KNEE ARTHROPLASTY WITH TWO-YEAR FOLLOW-UP

Introduction Robotic arm assisted total knee arthroplasty(RA-TKA) has gained popularity. Yet for postoperative pain and patient reported outcomes, high quality evidence is lacking. We hypothesize that RA-TKA would provide better postoperative pain control and patient reported out...

International Travel for Organ Transplantation: 2024 Multinational Survey of Routes, Organs, and Donor Types

BACKGROUND: International travel for organ transplantation (ITOT) reportedly affects ≥2% of global solid organ transplant activity, yet detailed information about ITOT participants, organ types, travel configurations, and clinical settings remains scarce. Previous research has fo...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Stroke survivors’ health priorities and targeted interventions in home-based post-discharge rehabilitation

<title>Abstract</title> Background This study aimed to describe health problems of the stroke survivors and the corresponding nursing interventions implemented during 12-week home-based post-discharge rehabilitation. Methods This was a descriptive secondary analysis within the co...

Targeting PRMT5 alleviates diabetic cardiomyopathy: mechanisms involve Ndufs2 R118 dimethylation-mediated complex I protection and serum PRMT5 as a biomarker

Abstract Background Diabetic cardiomyopathy (DCM) is defined by progressive cardiac dysfunction driven by myocardial ATP depletion, where mitochondrial electron transport chain (ETC) Complex I dysfunction acts as a critical factor. Protein arginine methyltransferase 5 (PRMT5) mai...

Cost utility analysis of two BK polyomavirus screening strategies: quantitative polymerase chain reaction vs 2-stage approach

Screening for BK polyomavirus (BKPyV) with quantitative polymerase chain reaction (qPCR) or a 2-stage approach with urine cytology followed by qPCR are acceptable strategies. However, the magnitude of the health benefits and incremental cost of adopting these 2 screening strategi...

Healing Following Endoscopic Reconstruction of the Anterior Skull Base in Patients With Sinonasal Malignancies

ABSTRACT Background Healing dynamics after anterior skull base (ASB) reconstruction following transnasal endoscopic surgery (TES) for sinonasal malignancies remain poorly characterized. This study aimed to describe the postoperative healing process, quantify time to healing, iden...

Diagnosis and analysis of plasma phosphorylated tau 217 in a memory clinic cohort: limitations of Generative Pre-trained Transformer-5

INTRODUCTION: No published studies have evaluated the application of Generative Pre-trained Transformer-5 (GPT-5) in the analysis of memory clinic patient clinical notes or the interpretation of plasma phosphorylated tau (P-tau) 217 values. We compared Alzheimer's disease (AD) pr...

Surface selection at the gripping interface for tensile testing per ASTM F2516 affects the pseudoelastic stress-strain response of Nitinol

Complications such as premature failure and sample slippage associated with testing uniform cross-sectioned samples using conventional gripping systems are well known within the testing community. While these complications can be avoided for most materials using dogbone-shaped sa...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...