Qingdao National Laboratory for Marine Science and Technology

Uncertainty quantification-driven shear wave velocity prediction using a spatiotemporal Bayesian neural network

Abstract Shear wave velocity (Vs) is a key parameter used for seismic data processing and evaluating oil and gas reservoirs. Conventional logging and machine learning methods are hampered by the provision of fixed Vs predictions, which limits their capacity to effectively quantif...

Energetic near-inertial waves induced by winter storms and mesoscale eddies in the subtropical Northwestern Pacific Ocean

Abstract. Near-inertial waves (NIWs) play a fundamental role in transferring wind energy into the ocean interior and sustaining diapycnal mixing, yet their wintertime characteristics and interactions with mesoscale eddies remain insufficiently understood. Using subsurface mooring...

FBMN-Guided Discovery of Cyanogrisides from Mutant Strain CRM005 and Structural Diversification

Abstract Through genome mining and metabolomic analysis of the mutant strain CRM005, combined with feature-based molecular networking (FBMN) deduplication, five novel natural cyanogrisides (1–5) were selectively isolated and characterized, alongside six previously reported analog...

Fluid–substrate coupled controls on mineral‑phase selection in the Kunlun hydrothermal system

Abstract Mineral precipitation at submarine hydrothermal vents transfers redox‑sensitive elements from the lithosphere to the ocean. However, conventional plume and sediment‑trap sampling poorly preserves particle‑scale signatures generated at reactive interfaces, hindering robus...

Design, Synthesis, and Anti-Inflammatory Activity Evaluation of Novel thieno[2,3- d ]Pyrimidin-4(3 H )-One-Based NLRP3 Inflammasome Inhibitors

Abstract The NLRP3 inflammasome plays a critical role in the pathogenesis of inflammatory diseases and has emerged as a promising therapeutic target. Our preliminary studies revealed that istradefylline, an anti-Parkinsonian agent, exhibits moderate NLRP3 inhibitory activity. Fur...

FoxL2 exhibits two-stage expression and maintains the ovarian niche in a lophotrochozoan

The genetic pathways governing sex determination remain a key enigma in lophotrochozoans, a major branch of bilaterian animals, hindering a comprehensive understanding of their evolution. Here, we enable genetic analysis in the gonochoristic scallop Chlamys farreri by developing...

Dual Magnetite Formation Pathways in Abyssal Serpentinites From the Mid‐Atlantic Ridge

Abstract Serpentinization, which involves hydrothermal alteration of olivine and pyroxene in ultramafic rocks, generates magnetite and strongly modifies the magnetic properties of oceanic lithosphere. However, the microstructural pathways of magnetite formation and their bulk mag...

Multifaceted Cross-Rational Modification of the α2,3-Sialyltransferase MsST for High-Efficiency Production of 3′-Sialyl-3-fucosyllactose via One-Pot Cascade Reaction

Abstract 3′-Sialyl-3-fucosyllactose (3′S3FL) is a representative fucose-containing sialylated human milk oligosaccharide with distinctive biological functions, but its in vitro synthesis is limited by the poor tolerance of α2,3-sialyltransferases toward fucosylated acceptors. Her...

Single-nucleus transcriptomics reveals cellular signatures of adaptive remodeling in the adult oyster nervous system after the life-history transition

How nervous systems adapt to major life-history transitions remains poorly understood in indirectly developing animals. The Pacific oyster ( Magallana gigas ) undergoes a planktonic-to-sessile transition during metamorphosis, but functional specialization of its adult ganglia rem...

Species and tissue-specific bioaccumulation and risk assessment patterns of heavy metals in bivalves from northern China

Bivalves play a crucial role in marine biogeochemical cycles and are highly sensitive to heavy metals (HMs) due to their filter-feeding behavior, making them widely recognized as bioindicators and an important human exposure pathway for these contaminants. This study employed sev...

Stoichiometric deviation and regulatory mechanisms of AOU–nutrient ratio in the oligotrophic Northwest Pacific Ocean

In oligotrophic oceans, the stoichiometric ratios of apparent oxygen utilization (AOU) to nutrients often deviate from the classical Redfield ratio, yet the mechanisms remain poorly constrained. Contrary to the commonly held view that these ratios are typically elevated, we found...

Poleward Redistribution of Tropical Cyclone Hazards over East Asia

Abstract Tropical cyclones (TCs) in the western North Pacific have undergone notable changes over recent decades alongside ocean warming and large-scale atmospheric circulation variability. Using TC best-track data from 1980 to 2025, we identify a pronounced poleward redistributi...

Transcriptomic Analysis of Somatic In Situ Regeneration in Green Macroalga Ulva prolifera (Ulvophyceae, Chlorophyta)

Somatic in situ regeneration (SISR) is a unique reproductive mode of the green-tide-forming alga Ulva prolifera. Based on reproductive and developmental characteristics, a previous study has speculated that SISR represents an early evolutionary form of somatic embryogenesis (SE)...

Discovery of an Iterative Terminal Condensation Domain Catalyzing Sequential Ester and Amide Bond Formation in Fungal Polyketide Synthase–Nonribosomal Peptide Synthetase Biosynthesis

Abstract Fungal polyketide–nonribosomal peptide (PK–NRP) hybrids are typically assembled by condensation (C) domains that form an amide bond between a polyketide and an amino acid unit. Here, we describe a family of bis-anthranilated PK–NRP hybrids, Neodiabzacids A and B, in whic...

Recent Advances in the Antihyperlipidemic Activity of Marine Polysaccharides

Hyperlipidemia is a chronic metabolic disorder in humans, contributing to the onset of cardiovascular diseases (CVDs) that remain the leading cause of death worldwide. Current clinical antihyperlipidemic agents are often accompanied by diverse adverse side effects. Therefore, dev...

Understanding projected uncertainty of Southern Ocean sea salt aerosol in CESM1-LE: role of internal variability

Abstract Southern Ocean (SO) sea salt aerosol is key to Earth’s energy budget, but its future changes are highly uncertain. Here using a 40-member ensemble from the Community Earth System Model Large Ensemble (CESM1-LE) project, we find that projected SO sea salt is modulated by...

Seasonal variations and controlling factors of nitrogen fluxes at the sediment-water interface in a semi-enclosed inland sea

Abstract. Nitrogen fluxes across the sediment-water interface and nitrogen removal from sediments are essential components of nitrogen cycle in semi-enclosed inland seas. However, the difficulty in observational sampling hinders continuous data availability that is necessary to u...

Hnf4α initiates hepatic lipid mobilization via activating fatty acid β-oxidation during starvation in tiger puffer (Takifugu rubripes)

Starvation is a natural stressor for fish, during which the liver adapts lipid metabolism to supply energy. Although our previous research clarified the effects of starvation on body composition in tiger puffer, the impact on hepatic lipid metabolism and the underlying molecular...

Hyperspectral Technology: A Method Framework for the Estimation of Metal Content in Cobalt-Rich Crusts

Cobalt-rich ferromanganese crusts are an important deep-sea mineral resource, and the ore grade is a key indicator for evaluating their resource potential. Conventional ore-grade assessment relies on representative samples and extensive laboratory analyses, posing significant cha...

The impacts of winter storms on sediment dynamics and shear front variability in the Yellow River Delta

Study region Yellow River Delta (YRD), China Study focus Delta evolution exhibits pronounced seasonal variability―seaward progradation in summer due to high sediment supply and weak ocean dynamics, versus winter retreat dominated by storm activity. However, winter storm impacts o...