Qingdao Municipal Hospital

Prediction of prognosis and treatment effect of cervical cancer by immunogenic cell death-related genes

Background Immunogenic cell death (ICD) is a potential mechanism that mediates adaptive immune responses during anticancer therapy. However, expression patterns and clinical implications of ICD related genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CES...

Global epidemiological and genetic burden of rare neurological diseases in children

We assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar. Four neurological conditions were classified as rare childhood neuro...

Low miR-106a-5p is associated with burn-related DVT and may regulate endothelial injury via TXNIP

Among burn patients, deep vein thrombosis (DVT) frequently arises as a critical complication. This article aims to explore the mechanism of miR-106a-5p in DVT in burn patients, providing a basis for identifying early diagnostic markers and developing therapeutic targets. This stu...

Proximal socioecological profiles and their association with psychosexual health among adolescent students: a cross-sectional study

To identify the proximal socioecological profiles of adolescents and explore their associations with psychosexual health. A questionnaire survey was administered to 3,419 students aged 14–19 from three high schools in Shandong Province. Based on the socialecological theory, ten p...

Eupatilin Alleviates Acute Myocardial Ischemia‐Reperfusion Injury in Rats via the Akt/GSK‐3β Pathway by Targeting COXs

ABSTRACT Eupatilin confers cardioprotection against myocardial ischemia‐reperfusion injury (MIRI). Cyclooxygenases (COXs) serve as key rate‐limiting enzymes for prostaglandin biosynthesis. This study investigated the effects of eupatilin on COXs. H9c2 cells subjected to oxygen‐gl...

Work-related musculoskeletal disorders among teachers in China: a scoping review of prevalence and associated factors

Work-related musculoskeletal disorders (WMSDs) represent a prominent occupational health issue among teachers. Their high prevalence not only undermines teaching effectiveness but also impairs teachers’ quality of life. This study aimed to investigate the prevalence of and factor...

An intelligent OCR-LLM prescription review system for inpatient narcotic and psychotropic drugs

This study aimed to construct an intelligent prescription review system for inpatient narcotic and psychotropic drugs based on deep learning-based optical character recognition (OCR) and a local large language model (LLM) and evaluate its review performance and closed-loop manage...

UHPLC‐MS/MS‐Based Quantification of 14 Renshen Guben Oral Liquid–Related Constituents in Cancer Patients With Neutropenia

OBJECTIVES: This study aimed to develop and validate a UHPLC-MS/MS method for the simultaneous determination of 14 constituents related to Renshen Guben Oral Liquid (RSGB) in human plasma and to explore concentration-absolute neutrophil count (ANC) associations in cancer patients...

Antibody-Drug Conjugates in the Treatment of Esophageal Cancer

Esophageal cancer remains one of the most lethal malignancies worldwide, with particularly poor outcomes following disease progression after first-line chemoimmunotherapy. Antibody-drug conjugates (ADCs) have emerged as a transformative therapeutic class that combines the targeti...

Long-term effects of a family-centered comprehensive lifestyle intervention on body composition and cardiometabolic indicators in school-aged obese children aged 6–12 years

Childhood obesity increases risks for metabolic and cardiovascular disease, yet long-term effectiveness of family-centered interventions remains unclear. This retrospective study evaluated associations between a family-centered comprehensive lifestyle intervention and changes in...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

One vs twelve month aspirin after percutaneous coronary intervention for acute myocardial infarction: individual patient-data analysis of TARGET-FIRST and ULTIMATE-DAPT trials

Giuseppe Tarantini, Xiaojuan Zhang, Luca Nai Fovino, Jing Kan, Zhen Ge, Guillaume Cayla, Pieter C Smits, Benjamin Honton, Valeria Paradies, Yann Poezevara,

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...