Qilu Hospital of Shandong University

Joint associations of cardiovascular health and depression with all-cause mortality among middle-aged and older adults

To examine the association between cardiovascular health (CVH), assessed using the American Heart Association’s Life’s Essential 8 (LE8) score, and depression, and to evaluate their independent and joint associations with all-cause mortality among adults aged 50 years and older....

Integrating neuroimaging, transcriptomics and single-cell sequencing identifies candidate molecular features of cortical vulnerability in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that leads to reductions in cortical surface area (SA) and thickness (TH). However, the genetic and molecular mechanisms underlying these cortical structural alterations remain unclear. This st...

Triglycerides and gestational diabetes mellitus: integrated clinical and genetic evidence linking LPL-related lipid metabolism

Abstract Background Gestational diabetes mellitus (GDM) is associated with adverse maternal and offspring outcomes, and disturbances in lipid metabolism may contribute to its metabolic pathophysiology. Elevated triglyceride (TG) levels have been consistently associated with GDM;...

Enhanced mortality prediction using frailty models in cardiac surgery patients: evidence from the MIMIC-IV database

The Frailty Index based on Laboratory Tests (FI-Lab) and the Hospital Frailty Risk Score (HFRS) represent two frailty measures, yet their comparative and combined prognostic utility in cardiac surgical populations remains unclear. We conducted a retrospective cohort study using t...

Comparative Efficacy of Bone Defect Filler Strategies Following Lesion Debridement for Osteonecrosis of the Femoral Head: A Systematic Review and Network Meta‐Analysis

ABSTRACT Objective This study aimed to systematically review and compare the clinical and radiographic outcomes of different bone defect filler materials following lesion debridement for osteonecrosis of the femoral head (ONFH). Existing evidence on filler materials relies heavil...

Lateral transperitoneal versus retroperitoneal laparoscopic adrenalectomy for large (≥ 50 mm) pheochromocytoma: a single-centre retrospective study

Laparoscopic adrenalectomy (LA) has gained popularity for the surgical treatment of large pheochromocytomas in recent years. However, the perioperative outcomes of the lateral transperitoneal and lateral retroperitoneal approaches remain uncertain. In addition, owing to the catec...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

NIR‐Responsive CaMoO 4 /Mo 3 N 2 Heterojunction Modified Biomimetic Periosteum: Synergistic Anti‐Infection and Promotion of Bone Defect Repair

ABSTRACT Treating infected bone defects remains a formidable clinical challenge due to robust bacterial antioxidant resistance and severe microenvironmental deterioration. Herein, an antibacterial biomimetic periosteum (ABP) is rationally engineered by in situ anchoring ultrasmal...

Suturing strategies for annular defects following lumbar discectomy: a structured narrative review and a hypothesis-generating functional assessment framework

Residual annular defects after lumbar discectomy may contribute to recurrent disc herniation, and several repair strategies—including direct annulus-to-annulus suturing, bone-anchored repair, and soft-tissue augmentation—have been described. However, evidence directly comparing s...

Selection and prediction of targeted serum protein biomarkers for early diagnosis of esophageal squamous cell carcinoma

Achieving early diagnosis of esophageal squamous cell carcinoma (ESCC) is crucial for reducing the disease burden. This study aims to identify potential serum protein biomarkers associated with the early diagnosis of ESCC in two independent populations and further develop diagnos...

Sclareol Production Driven by Advanced Synthetic Biology Strategies

Abstract Sclareol, a plant-derived diterpene, holds significant industrial value in perfumery, pharmaceuticals, and agriculture. Traditional production from Salvia sclarea or chemical synthesis has faced challenges such as low yield, high cost, and sustainability concerns. Recent...

CD80-targeted songorine nanotherapy restores PINK1-dependent mitophagy in proinflammatory macrophages for osteoarthritis treatment

Synovial macrophage-mediated inflammation and mitochondrial dysfunction are increasingly implicated in osteoarthritis (OA) progression, yet targeted restoration of mitochondrial quality control remains challenging. Here, we developed a macrophage-targeted, targeted delivery nanop...

Comparison of clinical efficacy and gut microbiota characteristics in children with ASD treated with fecal microbiota transplantation and ketogenic diet

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and interaction, along with restricted, repetitive patterns of behavior. It is often accompanied by gastrointestinal dysfunction and gut microbiota dysbiosis. Feca...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Targeting p38α promotes Parkin-mediated mitophagy to attenuate severe acute pancreatitis via suppressing the mtDNA/cGAS-STING signaling pathway

Abstract Severe acute pancreatitis (SAP) is a life-threatening acute inflammatory disorder characterized by systemic inflammation and high mortality, for which specific targeted therapeutic strategies are still severely lacking in clinical practice. Mitochondrial dysfunction and...

A multiomics-clinical model to predict treatment response in psoriasis

Psoriasis is a chronic inflammatory skin disease with highly variable responses to biologic therapies. Predictive tools to guide personalized treatment remain an unmet clinical need. To develop and validate a multiomics-clinical model for predicting a 75% reduction in the Psorias...

Lower respiratory microbiome and metabolome alterations in pediatric ARDS secondary to community-acquired pneumonia

Abstract Background Pediatric acute respiratory distress syndrome (ARDS) is a severe complication of community-acquired pneumonia (CAP) with high mortality, but the microbial and metabolic mechanisms driving its onset remain unclear. This study aimed to characterize these disturb...

Hepatocyte Hedgehog activation attenuates acetaminophen-induced liver injury through a Vegfa-associated vascular response

Abstract Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure, yet early pathways linking hepatocellular stress to tissue integrity remain incompletely defined. Here, we demonstrate that canonical Hh signaling is rapidly activated in centrilobula...

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Triple-negative breast cancer (TNBC) is characterized by high metastatic tendency and poor prognosis, largely driven by dynamic crosstalk between cancer cells and the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are a major component of the TME, yet their fu...