Qilu Hospital of Shandong University

ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility

Fatty Acid Oxidation (FAO) dysfunction induces pro-fibrotic transition in tubular epithelial cells (TECs) and contributes to renal fibrosis in chronic kidney disease (CKD); however, the drivers of metabolic reprogramming in TECs remain unclear. We investigate the role of aldehyde...

The Effects of Acupuncture at Shuigou (GV26) on Patients With Disorders of Consciousness: An EEG Nonlinear Dynamics Analysis

Background Disorders of consciousness (DOC) lack objective biomarkers. We evaluated the immediate cortical effects of acupuncture at Shuigou (GV26) in DOC patients using nonlinear EEG parameters: approximate entropy (ApEn), Lempel–Ziv complexity (LZC), correlation dimension ( D 2...

Reduced SRSF1 Expression Correlates with LCK Exon Skipping and Impaired Treg Induction in Immune Thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction and impaired regulatory T-cell (Treg) function, yet its molecular basis remains poorly defined. Here, we show that CD4+ naive T cells from patients with ITP exhibit dim...

A tumor-on-a-chip model reveals and targets reciprocal macrophage–NK cell crosstalk to advance immunotherapy screening

Effective cancer immunotherapy is hindered by immunosuppressive crosstalk within the tumor microenvironment. We engineered a tumor immune microenvironment-on-a-chip (TIMoC) that recapitulates the vascularized, hypoxic, and spatially organized niche of human solid liver tumors. We...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

A seven-gene signature diagnostic model for early-onset colorectal cancer and the tumor-suppressive role of SLC26A2 via redox modulation

The rising incidence and poor prognosis of early-onset colorectal cancer (EOCRC) highlight an urgent need for effective diagnostic biomarkers. This study integrates RNA sequencing data with machine learning algorithms to identify EOCRC-specific genes and construct a diagnostic mo...

Comparison of Two Specimen‐Extraction‐Site Loop Ileostomy Construction Strategies After Laparoscopic Low Anterior Resection: A Retrospective Study

ABSTRACT Background Specimen‐extraction‐site (SES) loop ileostomy has been used to avoid an additional abdominal incision after laparoscopic low anterior resection. However, the optimal technique for constructing this type of ileostomy remains uncertain. This study aimed to compa...

Cumulative body mass index burden from childhood to mid-adulthood in relation to subclinical cardiovascular outcomes: The potential mediating role of cardiovascular risk factors

The associations of long-term body mass index (BMI) exposure, including both cumulative burden and increasing trends from childhood to adulthood, with subclinical cardiovascular outcomes remain incompletely understood, especially across distinct life stages. This study aimed to e...

The deubiquitinase PSMD14 accelerates cervical cancer progression, with thiolutin offering a novel therapeutic approach

Abnormal function of deubiquitination enzymes is implicated in cancer progression. However, the role of the 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) in cervical cancer development and its underlying mechanisms remain poorly understood. In our study, we evaluated t...

SPARC Promotes Corneal Epithelial Wound Healing Through β-catenin Nuclear Translocation and c-Met Activation

Purpose: To investigate the molecular mechanism through which secreted protein acidic and rich in cysteine (SPARC) facilitates corneal epithelial wound healing via the β-catenin/c-Met signaling pathway. Methods: Wild-type C57BL/6 mice, Sparc-/- mice, and human corneal epithelial...

Early echocardiographic changes during hematopoietic stem cell transplantation

Patients undergoing hematopoietic stem cell transplantation (HSCT) are exposed to intensive conditioning regimens that may impose substantial cardiac stress during the peri-transplant period; however, early cardiac functional changes during this phase remain poorly characterized,...

Dual-targeted bioengineered bacterial extracellular vesicles ameliorate senile osteoporosis via SAE1-mediated NAT10 SUMOylation and ac4C-dependent glycolysis

Senile osteoporosis (SOP) is an age-related skeletal disease characterized by progressive bone loss and the deterioration of bone microarchitecture. Promoting the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is a potential strategy for SOP intervention...

Biophysical reprogramming of immunosuppressive neutrophils by cold atmospheric plasma reinvigorates antitumor immunity

Neutrophils are increasingly recognized as key orchestrators of the immunosuppressive tumor microenvironment, yet their intrinsic plasticity, short lifespan and resistance to genetic manipulation have impeded therapeutic targeting. Here, we report a non-pharmacological, biophysic...