Qassim University

Novel pyrazolo[3,4-d]pyrimidine–hydantoin hybrids as selective anticancer agents: Synthesis, cytotoxicity, structural activity relationship (SAR), and molecular docking studies

Cancer remains one of the most serious global health challenges, and the limited selectivity and high toxicity of many current chemotherapeutic agents highlight the urgent need for new, more effective anticancer drugs. In this study, a novel series of pyrazolo[3,4-d]pyrimidine de...

Metabolite profiling and molecular docking insights into the wound healing efficacy of Pelargonium zonale in a rat burn model

Pelargonium zonale has a long history of use in traditional medicine for wound healing, supported by scientific evidence of its topical, hemostatic, and antibacterial properties. The current study aims to comprehensively investigate the wound healing potential and phytochemical p...

One Subspace, Many Residuals: Columnwise Stopping and Rank Deflation for Block Projected Iterated Tikhonov Regularization

Discrete ill-posed problems with several right-hand sides and a common forward operator arise in multichannel imaging and in repeated or parameter-dependent experiments. A block Golub–Kahan reduction builds one solution subspace for all right-hand sides, and iterated Tikhonov reg...

Burden of CNS neoplasms in the Middle East and North Africa from 1990 to 2023, with projections to 2050

Central nervous system (CNS) neoplasms are uncommon but highly consequential malignancies that account for substantial neurological disability and premature mortality. The Middle East and North Africa (MENA) region is marked by rapid population growth, aging, and uneven health sy...

Fractional q-Starlikeness in Mittag–Leffler and Limaçon Domains

In this paper, we use a normalized fractional q-derivative operator, constructed by combining Jackson’s q-difference operator with a fractional q-integral, to introduce two subclasses of normalized analytic functions in the open unit disk whose fractional transforms are starlike...

A Hybrid ViT-ECA-CF Framework with Adaptive Loss Reweighting for Imbalanced White Blood Cell Classification

Background: White blood cells (WBCs), also known as leukocytes, play a central role in immune defense, and accurate WBC classification is essential for a hematological assessment and computer-assisted diagnosis. However, a severe class imbalance remains a major challenge in deep-...

An Optimized Audio–Visual Deepfake Detection Framework Using Mamba Vision Transformers with Linear Complexity

The rise of advanced deepfake technologies presents new challenges to media authenticity, making it harder to spot manipulated videos through traditional approaches. Current approaches have a quadratic time complexity O(n2), poor cross-dataset generalization with 20 to 35% accura...

An Explainable Deep Learning Framework for Musculoskeletal Abnormality Detection

Accurate detection of musculoskeletal abnormalities from radiographs remains challenging because abnormal findings can be subtle and radiographic appearance may vary considerably across examinations. This study aimed to develop and systematically evaluate a deep learning framewor...

An AI-Enabled Multi-Level Governance Framework for Consulting and Research Institutes in Saudi Public Universities

This study examines the governance of institutes of studies and consulting services in Saudi public universities, which operate as hybrid entities combining academic and contract-based consulting functions. Despite their strategic role, these institutes face governance challenges...

Prevalence and clinical characteristics of cracked posterior teeth among adult patients referred to selected endodontic centres in Saudi Arabia: a cross-sectional study

Cracked posterior teeth represent a persistent diagnostic and therapeutic challenge in dental practice. When undetected, crack propagation may result in pulpal and periapical complications. Epidemiological data on cracked teeth in Saudi and Middle Eastern populations remain limit...

Optimal Control and Cost-Effectiveness Analysis of Measles Transmission

This study develops and analyzes a deterministic compartmental model for measles transmission incorporating two-dose vaccination, imperfect dose-specific vaccine protection, breakthrough infection, and nonlinear saturated incidence. The population is divided into susceptible, fir...

Geochemical Profiling and Health Risk Assessment of Heavy Metals in Yemeni Bottled Water: A Multivariate Statistical Approach

Objectives The quality and safety of bottled drinking water are of growing concern in Yemen due to increasing dependence on groundwater resources and potential contamination by trace metals. This study presents an integrated secondary analysis of previously published inductively...

Depressive, Anxiety, and Stress Symptoms Among Respiratory Therapists in Two Tertiary Hospitals in Saudi Arabia: Differences According to Sociodemographic Characteristics

Background: Respiratory Therapists (RTs) work in high-stress environments, predisposing them to psychological distress. This study evaluated the proportion of depressive, anxiety, and stress symptoms and their differences across sociodemographic groups among RTs in two Saudi Arab...

From Antimicrobial Biomaterials to Infection-Resilient Interfaces: Engineering the Host, Microbe, and Material Interface Against Drug-Resistant Biofilms

Drug-resistant biofilm infections remain a major challenge for medical devices and implants. Biofilm formation can reduce antimicrobial effectiveness through physiological heterogeneity, tolerance, persistence, and interactions with the host and biomaterial surface. Antimicrobial...

Addition of low-load blood flow restriction training to conventional physiotherapy improves handgrip strength and function in patients with lateral epicondylitis at the short-term: A single-blind randomized clinical trial

Background Evidence regarding Blood Flow Restriction (BFR) training for the management of lateral epicondylitis (LE) remains limited and conflicting, although BFR has shown potential to improve muscle strength in other musculoskeletal rehabilitation settings. Objective To investi...

Prevalence of malaria in the United Villages region, Northern Khartoum State, during armed conflict

Malaria remains a major public health concern in sub-Saharan Africa, where under-resourced health systems and environmental conditions continue to facilitate transmission. In Sudan, the situation has been further aggravated by the ongoing armed conflict that began in April 2023,...

Energy-aware scheduling approach for enhanced performance of parallel applications in simulated heterogeneous cloud environments

Energy-constrained workflow scheduling seeks to minimize application makespan while preserving a finite energy budget across heterogeneous DVFS-enabled resources. Existing pre-assignment methods generally distribute energy using a single task-level criterion, which can restrict t...

Chebyshev Spectral Collocation with an Exact Operational Integration Matrix for Nonlinear Volterra–Hammerstein Equations

This paper proposes a Chebyshev spectral collocation method for nonlinear Volterra–Hammerstein integral equations of the second kind with smooth kernels. We approximate the unknown solution using a finite Chebyshev expansion and place collocation points at the Chebyshev–Gauss–Lob...

Design of a novel chimeric multi-epitope vaccine construct against Staphylococcus lugdunensis using pan-genome analysis and immunoinformatics approaches

Abstract Staphylococcus lugdunensis has emerged as an increasingly important opportunistic pathogen associated with invasive infections and rising antimicrobial resistance, creating a need for new preventive approaches. In this study, a reverse-vaccinology strategy integrated wit...

Reimagining sustainable education in Africa through decolonial pathways and indigenous knowledge systems

Despite the growing recognition of Indigenous Knowledge Systems (IKS) as vital for the sustainability of education in Africa, the majority of education systems across the continent still embody colonial epistemologies that marginalise local knowledge traditions. Existing literatu...