Public Health Agency of Canada

AI-designed prion-capping proteins provide evidence that prion fibril ends are replication-competent surfaces that contribute to prion seeding activity and infectivity

ABSTRACT End-elongation of amyloid fibrils is a prevailing theory to explain prion replication, but direct experimental evidence for this phenomenon is limited by the lack of research tools. To serve as molecular probes for prion fibril termini, here, we designed protein binders...

A decision-tree for trend analyses following major survey redesigns: an analysis using the Canadian Community Health Survey (CCHS)

Abstract Background Monitoring health inequality trends is essential for assessing progress, stagnation, or regression on the reduction of health inequalities; assessing the impact of certain policies on health inequalities; and identifying emerging areas of concern. Because ineq...

Rapid, low-cost, and portable molecular detection of HIV-1 subtype B and HCV 1a directly from blood

Accessible molecular diagnostics for human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) remain constrained by the cost and infrastructure requirements of existing molecular point-of-care platforms. In this study, we describe a portable, proof-of-concept molecular...