Princess Margaret Cancer Centre

Autoimmune glial fibrillary acidic protein astrocytopathy: a case report from Hong Kong

Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a rare autoimmune disorder first described in 2016. 1 It typically presents as acute or subacute meningitis, encephalitis, and/ or myelitis, with symptoms such as fever, cognitive decline, limb weakness, and au...

Role of consolidative surgery after chemotherapy in recurrent/metastatic adrenal cortical cancer (ACC): Princess Margaret Cancer Centre experience

Recurrent/Metastatic (R/M) ACC is aggressive with few effective treatment options. The role of surgery after chemotherapy remains unclear. Moreover, prognostic factors in R/M ACC are not well defined. R/M ACC patients treated at Princess Margaret Cancer Centre (2002–2019) were re...

Lupus Double-Negative B Cells Harbor Expanded Somatic Mutations in Lymphoma-Relevant Pathways

Objectives Systemic lupus erythematosus (SLE) patients have a 2–7-fold increased risk of hematologic malignancies, particularly B-cell non-Hodgkin lymphoma (B-NHL).[1] Although germline susceptibility shared between SLE and B-NHL is minimal,[2] somatic evolution of autoreactive B...