Poznan University of Medical Sciences

Recommendations of Multiple Sclerosis and Neuroimmunology Section of the Polish Neurological Society and the Polish Society of Gynecologists and Obstetricians for family planning and pregnancy management in women with multiple sclerosis: an update

INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the Central Nervous System that most commonly affects females of reproductive age. Therefore, the issue of family planning is relevant in this population, especially in the context of starting a...

Associations of IL-2, IL-6 and IL-10 Gene Polymorphisms with Biochemical Parameters and Calcineurin Inhibitor Dosing in Kidney Transplant Recipients

Background/Objectives: Kidney graft dysfunction remains a major challenge limiting long-term transplant survival despite advances in immunosuppressive therapy. Cytokine signaling pathways have been implicated in the regulation of alloimmune responses and chronic inflammation, but...

Geriatric nutritional risk index as a potential prognostic indicator in pancreatic cancer: evidence from a systematic review and meta-analysis

Malnutrition is highly prevalent among patients with pancreatic cancer and has a substantial impact on prognosis, treatment tolerability, and quality of life. However, the prognostic significance of the Geriatric Nutritional Risk Index (GNRI), a simple and objective tool for asse...

Severe visual impairment as a complication of autism spectrum disorder

Purpose To report the irreversible vision loss caused by optic neuropathy in a course of a vitamin A deficiency. Methods Electroretinography (ERG) and pattern visual evoked potentials (PVEP) were used to establish a diagnosis, and to monitor the treatment in a child suffering fro...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

Preoperative Plasma Cell-Free DNA Integrity Index in Clear Cell Renal Cell Carcinoma: An Exploratory Case–Control Study

Background/Objectives: Evaluation of renal tumour masses relies on conventional imaging, which cannot reliably characterise the histopathological type, and no validated blood-based diagnostic marker is available for renal cell carcinoma. The cfDNA integrity index, the ratio of lo...

No Conscious Units: A Relational Theory of Consciousness and the Dissolution of the AI Consciousness Question

This paper challenges a largely unexamined assumption of contemporary consciousness studies: that consciousness is an intrinsic property of objects. Drawing on the Madhyamaka analysis of emptiness (sunyata) and dependent origination, and on independent convergences in relational...

Unmasking Behçet’s disease in the European population: a case series report

Behçet’s disease (BD) is rare in European populations. Because clinical and immunological characteristics may differ between Caucasians and Middle Eastern patients, we analyzed BD patients from the Polish population. Data from eight patients with BD treated at a rheumatology clin...

The evolution of thyroid cancer diagnostics: Historical milestones and their impact on contemporary clinical practice

Thyroid cancer represents the most prevalent malignancy of the endocrine system, with its incidence exhibiting a significant rise in recent years. Diagnostic methods have undergone profound evolution over the past century, progressing from basic clinical examination to a sophisti...

Sub‐ UV Trichoscopy for the Assessment of Acute and Subacute Form of Alopecia Areata

The authors declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

The impact of FTO and ADRB3 gene variants, physical activity and proper diet on weight gain and perinatal outcomes in pregnant women with obesity

This study aimed to evaluate the effects of FTO (rs9939609) and ADRB3 (rs4994) gene variants, dietary intervention, and physical activity on gestational weight gain and perinatal outcomes in women with obesity and early gestational diabetes (GDM). In this prospective study, 115 p...

Coronary Calcified Nodules: From Pathological Definitions to Intravascular Imaging- and Morphology-Guided PCI

Coronary artery calcification (CAC) is a hallmark of advanced atherosclerosis and a major determinant of procedural complexity during percutaneous coronary intervention (PCI). Once considered a passive consequence of vascular degeneration, CAC is now recognized as an active, high...

KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications - Supplementary Methods

Supplementary Materials and Methods for "KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications" accepted for publication in Haematologica (2026) The published article includes an abbreviated Methods sec...

KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications - Supplementary Methods

Supplementary Materials and Methods for "KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications" accepted for publication in Haematologica (2026) The published article includes an abbreviated Methods sec...