Post Graduate Institute of Medical Education and Research

Comparative analysis of low- and high-dose apheresis platelets in platelet-refractory patients with hematologic malignancies

Background Alloimmunization-induced platelet transfusion refractoriness represents a major clinical challenge in hematology-oncology. Optimal strategies for platelet support in this population remain to be established. Objective This study aimed to compare the efficacy of low-dos...

A narrative review of sildenafil dosing and monitoring by indication in neonatal pulmonary hypertension

Abstract Pulmonary hypertension in the neonate is a leading contributor to hypoxemic respiratory failure and carries substantial mortality across diverse etiologies, including persistent pulmonary hypertension of the newborn (PPHN), bronchopulmonary dysplasia-associated pulmonary...

Prophylactic interventions to prevent rebound pain after peripheral nerve block: a reply

We thank Mistry and Sukumaran [1] for their thoughtful comments on our network meta-analysis of prophylactic interventions for rebound pain following peripheral nerve block [2]. We agree that an important question is whether the observed reduction in rebound pain reflects true at...

[ 177 Lu]Lu‐PSMA‐617 Plus Short‐Course Priming With Enzalutamide in Metastatic Castration‐Resistant Prostate Cancer: A Single‐Arm Phase 2 Trial (Lu‐PRIME)

ABSTRACT Background [ 177 Lu]Lu‐PSMA‐617 has been an approved treatment modality for metastatic castration‐resistant prostate cancer (mCRPC). Recent studies have shown PSMA upregulation following enzalutamide, which may enhance the outcomes with [ 177 Lu]Lu‐PSMA‐617. This study a...

Bibliometric Analysis of Clinical Trials on Tobacco Use and Mental Health: Research Trends and Implications for Oral Health

Background: Mental illness and tobacco use are often associated. This study aimed to analyze the trends in tobacco use and mental health research published from 2014 to 2024, including oral health-related research within this literature, and to identify gaps for future work. Mate...

The effect of a telephonic reminder on fasting duration in children undergoing computed tomography scan under sedation in a resource-limited setting – A randomized controlled trial

Abstract Background and Aims: Prolonged preprocedural fasting remains common among children undergoing diagnostic imaging, particularly in low- and middle-income country (LMIC) settings where communication challenges and high patient turnover can limit effective counseling. It ca...

Generative drawing systems and emergent spiral formation

Emergent Spirals: Generative Drawing Systems and Emergent Spiral Formation is a practice-based research paper investigating how complex spiral structures can emerge through the repeated application of a simple manual drawing procedure. Developed through sustained studio research...

Generative drawing systems and emergent spiral formation

Emergent Spirals: Generative Drawing Systems and Emergent Spiral Formation is a practice-based research paper investigating how complex spiral structures can emerge through the repeated application of a simple manual drawing procedure. Developed through sustained studio research...

Effect of Single Session Solution Focused Circle Technique on Working Memory, Hope and Psychological Well-being Among Individuals with Depression: A Controlled Study

Background Depression is a common mental health condition that is often misunderstood, leading to delays in early intervention. It can impair working memory, reduce hope, and negatively affect psychological well-being. Although Cognitive Behaviour Therapy (CBT) is an effective fi...

Strengthening Tobacco Control through Multi-Stakeholder Engagement: The Uttarakhand Tobacco-Free Coalition (UTFC) for Protecting Youth and Communities

Abstract Tobacco use remains a significant public health concern in Uttarakhand, with 26.5% of adults reported to use tobacco (Global Adult Tobacco Survey [GATS] 2016–17). Although national frameworks such as the Cigarettes and Other Tobacco Products Act (COTPA), 2003 and the Nat...

A prospective observational study to evaluate the prevalence of severe asthma among subjects with difficult-to-treat asthma at a tertiary care center in North India

Background: Severe asthma accounts for disproportionate asthma-related morbidity, mortality, and healthcare costs, yet prospective data on its prevalence remain limited, particularly for developing countries. We aimed to determine the prevalence of severe asthma among subjects wi...

Marine chitinase BtChi disrupts cell wall integrity in Candida albicans and non-albicans species by chitin targeting and release of chitooligosaccharides

Abstract Increasing resistance to conventional antifungal drugs against Candida species, along with the limited availability of drug targets due to similarities between fungal and human cellular processes, necessitates alternative antifungal strategies. Chitin, a key polysacchari...

A prospective, randomized study comparing different therapeutic modalities for acute adenoviral conjunctivitis

PURPOSE: To compare the outcomes of three different therapeutic modalities in acute adenoviral conjunctivitis. DESIGN: Prospective randomized study. METHODS: A total of 65 eyes of 65 patients with nested polymerase chain reaction (PCR)-proven adenoviral conjunctivitis were enroll...

Insulin Resistance and Subclinical Myocardial Dysfunction in Type 2 Diabetes: A Cross-sectional Study

Introduction: Left atrial (LA) strain and left ventricular (LV) global longitudinal strain (GLS) on two-dimensional echocardiography in asymptomatic Type 2 diabetes mellitus (T2DM) patients might help recognise subclinical myocardial dysfunction in these patients. Since T2DM is a...

P1.136. Toward Vagal-Sparing Esophagectomy: Defining Surgically Reproducible Zones of Pulmonary Autonomic Preservation

Abstract Topic Esophageal Cancer: Other Background Pulmonary complications remain a major cause of morbidity after transthoracic esophagectomy. Injury to pulmonary vagal branches during mediastinal lymphadenectomy may contribute to postoperative respiratory dysfunction. Precise s...

P1.133. Strengthening the Host Before Surgery: Role of Immunonutrition in Esophagectomy for Esophageal Cancer

Abstract Topic Esophageal Cancer: Other Background Esophageal cancer commonly presents with dysphagia and malnutrition. Esophagectomy following neoadjuvant chemoradiation is the standard treatment for locally advanced disease but is associated with significant postoperative morbi...

Community Street Play Versus Facility-based Screening for Mental Health Literacy in Rural India: A Mixed-methods Quasi-experimental Study

Background: Community-based approaches to mental health literacy (MHL), including street theatre, remain underrepresented. No study has compared street play with primary care facility-based screening as parallel MHL strategies. This study evaluated the effectiveness and acceptabi...

Non-ST Elevation Myocardial Infarction After High-dose Intravenous Immunoglobulin in a Patient with Systemic Lupus Erythematosus

Intravenous immunoglobulin is frequently used in the treatment of autoimmune and hematologic disorders. While generally well tolerated, intravenous immunoglobulin administration can rarely precipitate serious cardiovascular events, including acute coronary syndrome, particularly...

Epidemiology of Kawasaki disease in Chandigarh, India (2020–2024): COVID-19 pandemic-related decline and post-pandemic resurgence

BACKGROUND: Kawasaki disease is the leading cause of acquired heart disease in children worldwide. Previous studies from Chandigarh, India, documented a rising incidence until 2019. The COVID-19 pandemic, with its infection-control measures and emergence of multisystem inflammato...

Drug stock-outs in HIV, tuberculosis, and malaria programs: a systematic review

Background Stock-outs of antiretroviral, anti-tuberculosis, and anti-malarial medicines remain a major challenge in low- and middle-income countries, affecting both health systems and patient outcomes. This systematic review aimed to synthesize evidence on the causes, consequence...