Post Graduate Institute of Medical Education and Research

Serum Ang-1, sFLT-1, and sST2 Profiles Distinguish Anti-VEGF Responders in Diabetic Macular Edema

Purpose: Diabetic macular edema (DME) remains a significant cause of vision loss despite the widespread use of anti-VEGF therapy. Nearly half of patients experience suboptimal responses in both anatomical and functional outcomes. This study correlates molecular signatures with cl...

Nutritional and Biochemical Correlates of Disease Severity and Hospitalization in Adults with Drug-resistant Tuberculosis: A Prospective Study from North India

BACKGROUND: Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in high-burden countries. While microbiological diagnosis is central to management, factors determining disease severity and hospitalization at presentation are less well characterized, partic...

HOOK3::FGFR1 Fusion in a Background of FGFR1 Amplification in Childhood B‐Cell Acute Lymphoblastic Leukemia

The authors declare no conflicts of interest. Data shall be shared on request to the corresponding author.

Does EQ-5D measure the most relevant aspects of health across cultures? Findings from a multi-country qualitative and card-sorting study

The EQ-5D is a widely used measure of health-related quality of life (HRQoL) in health services and economic evaluations globally. However, its cross-cultural content validity remains underexplored. This study assesses the relevance and adequacy of EQ-5D across diverse cultural c...

Apc-deficient pituitary stem cells drive adamantinomatous craniopharyngioma through senescence-associated inflammation

Abstract Adamantinomatous craniopharyngiomas (aCPs) are complex intracranial neoplasms that arise in the sellar and suprasellar region of the brain, affecting the endocrine and nervous systems, causing severe sequelae. Although most of aCPs are driven by somatic mutations in β-ca...

Effectiveness of Community-Based Educational Interventions in Reducing Blood Pressure in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

Abstract Blood pressure (BP) is a major health burden in low- and middle-income countries (LMICs), where effective control remains a challenge. Community-based education may help improve outcomes in these settings. To systematically review and assess the impact of community-based...

Safety and efficacy of indigenous ultrathin-strut versus international thin-strut drug-eluting coronary stents in percutaneous coronary intervention: a systematic review of randomized controlled trials

Introduction Ultrathin-strut drug-eluting stents (DES) have been developed to enhance vascular healing and reduce restenosis following percutaneous coronary intervention (PCI). Indigenous biodegradable-polymer ultrathin-strut DES are increasingly used in high-burden settings; how...

Loco-regional radiopharmaceutical therapy in breast carcinoma using [177Lu]Lu-microseed implants: Development to proof-of-concept

Local recurrence following tumor resection and limited efficacy of existing therapies for residual or unresectable tumors remain major clinical challenges. To address this, we introduce two loco-regional therapeutic strategies: intraoperative radiopharmaceutical therapy (IORPT),...

Patch Test Relevance and Systemic Exposure Pathways in Eczema Patterns Suspected of Systemic Contact Dermatitis

ABSTRACT Background Systemic contact dermatitis (SCD) occurs when sensitised individuals react to an allergen delivered systemically. Indian data that relate clinical patterns, patch‐test relevance and systemic exposures are limited. Objectives (i) Characterise the clinico‐demogr...

Refractory Intrahepatic Bile Leak in a Young Patient After Blunt Abdominal Trauma: Technique of Endoscopic Management Using Cyanoacrylate Glue-Lipiodol Combination

ABSTRACT Bile leaks are commonly managed endoscopically with either sphincterotomy and/or biliary stenting. Historically, if these procedures failed, surgery was inevitable, carrying high morbidity. Data are sparse on the management of persistent or refractory bile leaks after fa...

Hyperpigmentation Disorders Management in India: A Delphi Based Expert Consensus on Epidemiology, Therapeutic Challenges, and the Evolving Role of Dermocosmetics

ABSTRACT Introduction Hyperpigmentation disorders impose a substantial clinical and psychosocial burden in individuals with darker skin phototypes, yet remain underrepresented in dermatological research. In India, where a large proportion of the population reports pigmentary conc...

A Giant in the Neck: Cytomorphology of a Rare Cervical Vertebral Lesion

BACKGROUND: Giant cell tumour of bone (GCTB) is a locally aggressive primary bone neoplasm that predominantly involves the epiphyseal-metaphyseal regions of long bones. Involvement of the mobile spine is uncommon, with cervical vertebral localization being particularly rare. Preo...

From stem cell therapy to precision regenerative cardiology: integrating the gut microbiota and multi-omics in myocardial infarction

Myocardial infarction (MI) remains a major cause of heart failure because extensive cardiomyocyte loss exceeds the limited regenerative capacity of the adult heart. Adult progenitor cell- and mesenchymal stem cell-based therapies promote cardiac repair predominantly through parac...

When the Review Reads Too Well: Responding to AI-Generated Peer Review

You receive reviewer comments on a submitted manuscript that are polished and lengthy, but strikingly generic. The review offers broad recommendations without engaging meaningfully with the content. The style makes you wonder whether the review had been generated, or heavily draf...

Methodological Guideline for Online Surveys in Health Research

ABSTRACT: Online surveys have gained increasing importance in health research because they are affordable, scalable, and able to reach hard-to-access or stigmatized populations. Although they are widely used, there is still limited consolidated guidance on managing the methodolog...

BRCA1 ‐mediated transcriptional repression of FABP3 – Implications for breast cancer progression and chemosensitivity

Transcriptional regulation of key target genes by BRCA1 is crucial for its diverse functions. Here, we report fatty acid-binding protein 3 (FABP3) as a novel BRCA1-repressible target gene. Functional BRCA1 represses FABP3 promoter activity while mutant BRCA1 breast cancer cell li...

Beyond Omalizumab: Emerging Biologic and Small Molecule Therapies in Chronic Spontaneous Urticaria

Chronic spontaneous urticaria (CSU) remains inadequately controlled by H1-antihistamines and omalizumab in a substantial minority of patients at every age. Recognition that mast cell activation proceeds through IgE-independent as well as IgE-dependent routes has exposed several t...

Consensus recommendations for standardising ILD multidisciplinary discussions in India

Abstract Background Interstitial lung diseases (ILDs) are complex, heterogeneous disorders that require accurate diagnosis and coordinated care. Multidisciplinary discussions (MDMs) are considered the gold standard for ILD management; however, in India, the implementation of stru...

Diagnostic performance and cutoff optimisation of the CTD Screen assay for ANA detection compared with HEp-2 IFA

Aim: Antinuclear antibodies (ANAs) are important in diagnosing systemic autoimmune rheumatic diseases (SARDs), and the HEp-2 cell indirect immunofluorescence assay (HEp-2 IFA) remains the gold standard for their detection. This study evaluates the utility and optimal cutoff of th...

Expanded Dengue Syndrome With Posterior Reversible Encephalopathy Syndrome

Dengue virus infection can present with a wide spectrum of clinical manifestations, ranging from mild febrile illness to severe disease with multiorgan involvement. Neurological complications, though less common, are increasingly recognized in severe dengue, with posterior revers...