Polish Academy of Sciences

Ferroptosis at the tumor–immune interface: seeking a middle ground between tumor eradication and T-cell fitness

Abstract Background Ferroptosis is an iron-dependent form of regulated cell death, which is manifested by the lethal accumulation of lipid peroxides. While it is considered a promising strategy for the elimination of apoptosis-resistant cancer cells, growing evidence highlights t...

Direct Immobilization of Living Poly(2-ethyl-2-oxazoline) Chains onto Mesoporous Silica: A Simplified Grafting-To Strategy for Hybrid Organic–Inorganic Materials

The development of straightforward and efficient strategies for the preparation of polymer-functionalized mesoporous silica remains an important challenge in the design of advanced hybrid materials. Herein, we report a novel and simplified approach to the covalent functionalizati...

Low-Dimensional Ionotronics

Abstract Ionotronics encompasses a broad range of phenomena and devices based either on the electron-controlled manipulation of ions in electrolytic media or on the use of ionic behavior to control electronic functionality. Although the term itself is relatively recent, the scien...

Influence of Ag2O on structural evolution, dissolution behavior and antibacterial response of sodium-calcium aluminoborophosphate glasses

The influence of low-level (0.25–0.75 mol%) silver oxide (Ag 2 O) substitution for Na 2 O on glass structure and in vitro dissolution of sodium–calcium aluminoborophosphate glasses was investigated. Spectroscopic analysis showed that the borate sub-network is dominated by BO 4 un...

Closing the Objectivity Loophole in Bell Tests on a Public Quantum Computer

ABSTRACT We have constructed and run a Bell test of local realism focusing on the objectivity criterion. Objectivity means that the outcomes are macroscopically confirmed by a few observers at each party. The IBM Quantum and IonQ devices turn out to be sufficiently accurate to pa...

Modelling resilient species for the restoration of the Green Dam in Algeria

Algeria has long suffered from ongoing desertification, resulting in the progressive loss of vegetation and soil erosion. This has had a severe impact on rural livelihoods in the north, making local communities more vulnerable and causing a decline in biodiversity. In an attempt...

Tailoring the Microarchitecture and Mechanical Properties of Styrene‐Hexyl Methacrylate PolyHIPEs via Microfluidic Emulsion Templating

Microfluidic emulsion templating enables unmatched control over pore size and ordering in polymerized high internal phase emulsions (PolyHIPE), yet its adoption for hydrophobic, chemically aggressive monomers is limited by the poor solvent compatibility of common chip materials a...

Impact of meteorological and oceanographic conditions on the state of sea ice in Hornsund, Svalbard over 23 years

Abstract. Sea ice in fjords affects local hydrography, ecosystems, glacier stability and coastal erosion. The full archive of historical SAR imagery at ∼50 m resolution (Envisat ASAR, RADARSAT-2 and Sentinel-1) capturing the Hornsund fjord, Svalbard was used to create an unpreced...

Fluctuations of Schensted row insertion

We investigate asymptotic probabilistic phenomena arising from the application of the Schensted row insertion algorithm, a key component of the Robinson–Schensted–Knuth (RSK) correspondence, to random inputs. Our analysis centers on a random tableau T with a given shape λ, which...

Under the Sea: Detection of Explosives Underwater Using Raman Spectroscopy

Secondary explosives such as 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and 2,4,6-trinitrotoluene (TNT) were commonly used in the production of many types of munitions during World War II and still continue to be used, for example, 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX) a...

Holographic is Hamiltonian, relatively

Abstract We show that a relative holographic energy coincides with the relative Hamiltonian energy.

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy

CD19-CAR-T cells are a major therapy for relapsed/refractory B-cell malignancies, yet ~50% of patients relapse after infusion. Clinical data suggest that tisa-cel treatment is associated with higher rates of CD19 mutation than axi-cel, though direct comparisons have been lacking....

Academic mobility and identity in transition: comparative insights from multilingual scholars across higher educational systems

Purpose This paper aims to examine how bi- and multilingual academics reconstruct professional identities during international mobility and how they exercise agency in relation to language hierarchies, institutional expectations, and belonging across higher education systems. Des...

Efficient in-vitro regeneration and transformation for CRISPR/Cas9-mediated genome editing of phytoene desaturase (PDS) gene in pea (Pisum sativum L.)

Key message The present study addresses optimization of in-vitro regeneration via direct organogenesis and Agrobacterium-mediated genetic transformation, enabling efficient multiplex CRISPR/Cas9-based genome editing of the phytoene desaturase (PsPDS) gene in pea. Abstract Pea (Pi...

A compilation of global bio-optical in situ data for ocean-colour satellite applications – version four

Abstract. A global in situ dataset for validation of satellite products from the ESA Ocean Colour Climate Change Initiative (OC-CCI) is presented. This version of the compilation, with data starting in 1996, extends to 2025, which is important for the validation of recent algorit...

Carbazolyl-Substituted Benzoic Anhydrides as Efficient Triplet Harvesters for High-Brightness Blue Organic Light-Emitting Diodes

Abstract A simple and efficient synthetic strategy for the preparation of carbazole-basedC2-symmetric anhydrides with donor−acceptor−donor (D−A−D) architecture is presented. Four benzoic anhydrides incorporating carbazole or 3,6-di-tert-butylcarbazole donor units, linked to the a...

Reverse Time Migration with Modified Nearly Analytical Discretization: Efficient Large-Scale High-Resolution Imaging and Aliasing Suppression

Abstract Reverse time migration (RTM) requires numerically solving the partial differential wave equation because analytical solutions are infeasible. A significant challenge in numerical methods arises from inaccuracies in derivatives approximation, making the numerical wave vel...

Social communication during a sow-piglet foraging paradigm

Offspring may use various sensory modalities to learn from the mother, but this has in pigs received relatively little research attention. The objective of this study was to investigate social cues between sow and piglet during a learning scenario related to foraging. We hypothes...

Kombucha Bacterial Cellulose Obtained from Tea Fermentation for Biomedical Applications

Abstract The symbiotic culture of bacteria and yeast (SCOBY) driving kombucha tea fermentation produces a cellulose pellicle with remarkable promise for biomedical applications. Unlike well-studied bacterial cellulose (BC), which is produced by single-strain cultures, the underex...

Adapted foundation models for breast MRI triaging in contrast-enhanced and non-contrast-enhanced protocols

Abstract Objectives To evaluate a DINOv2-based medical slice transformer (MST) for triaging abbreviated breast MRI by ruling out examinations with suspicious findings that are immediately actionable (Breast Imaging Reporting and Data System [BI-RADS] ≥ 4) across contrast-enhanced...