People's Liberation Army 401 Hospital

Integrated single-cell and spatial transcriptomic analysis characterizes a TNBC-enriched EP5-associated malignant epithelial program and prioritizes REEP4 in breast cancer

Triple-negative breast cancer (TNBC) exhibits pronounced epithelial-state plasticity, aggressive clinical behavior, and heterogeneous responses to immune checkpoint blockade (ICB)-based neoadjuvant therapy. Bulk transcriptomic analyses cannot resolve epithelial-state heterogeneit...

Interpretable laboratory-trajectory phenotypes for risk stratification of in-hospital critical events in cancer inpatients

Hospitalized cancer patients accumulate dozens of routine laboratory results within the first week of admission, but these are typically used only to flag individual abnormal values, and interpretability is a prerequisite for the bedside adoption of any clinical decision-support...

Adjuvant lenvatinib plus transarterial chemoembolization is associated with better outcomes than gemcitabine plus cisplatin in combined hepatocellular cholangiocarcinoma

To evaluate and compare the efficacy and safety of lenvatinib combined with transarterial chemoembolization (TACE) and gemcitabine plus cisplatin (GP) as adjuvant treatments for combined hepatocellular-cholangiocarcinoma (cHCC-CCA), and to explore the differential therapeutic ben...

Suturing strategies for annular defects following lumbar discectomy: a structured narrative review and a hypothesis-generating functional assessment framework

Residual annular defects after lumbar discectomy may contribute to recurrent disc herniation, and several repair strategies—including direct annulus-to-annulus suturing, bone-anchored repair, and soft-tissue augmentation—have been described. However, evidence directly comparing s...

Long-term effects of a family-centered comprehensive lifestyle intervention on body composition and cardiometabolic indicators in school-aged obese children aged 6–12 years

Childhood obesity increases risks for metabolic and cardiovascular disease, yet long-term effectiveness of family-centered interventions remains unclear. This retrospective study evaluated associations between a family-centered comprehensive lifestyle intervention and changes in...

Myasthenia gravis complicated by myocarditis associated with anti-titin and anti-VGKC antibodies: a case report

Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorder primarily affecting skeletal muscles. Although myocardial involvement is rare, MG-associated myocarditis can be life-threatening and may be overlooked because symptoms such as dyspnea and fatigue overlap with...

Comparative evaluation of selective media and key factors affecting isolation of V. cholerae and V. parahaemolyticus

Abstract Thiosulfate citrate bile salts sucrose (TCBS) agar is a widely used selective medium for the presumptive isolation of Vibrio spp, playing an essential role in food safety and public health surveillance. However, variations among commercial formulations may significantly...

Splenic Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma：Report of One Case.

Splenic Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma （EBV+IFDCS） is a rare low-grade malignant tumor typically associated with Epstein-Barr virus infection.Most patients are asymptomatic，and the splenic mass is often discovered incidentally during...

Apical hypertrophic cardiomyopathy complicated by multisystem embolism, anticoagulant overdose-induced iliopsoas hematoma, and subsequent cardiocerebral infarction: a cautionary case report on DOAC dosing in renal impairment

Abstract Background Apical hypertrophic cardiomyopathy (ApHCM) is a morphological variant of hypertrophic cardiomyopathy characterized by relative apical hypertrophy (wall thickness ≥ 15 mm) with a relatively favourable prognosis. Approximately 30% of patients with ApHCM develop...

Decoding hypoxia-driven microenvironment remodeling in bladder cancer reveals TPST1 as a key driver of metastasis

Hypoxia is a key feature of the bladder cancer tumor microenvironment, but its cellular organization, prognostic value, and functional effectors remain incompletely defined. Here, we integrated single-cell RNA sequencing, bulk transcriptomic cohorts, machine-learning modeling, im...

Latent profiles and influencing factors of missed nursing care among ICU nurses

Abstract Background Missed nursing care (MNC) is common in intensive care units (ICUs) and seriously threatens patient safety. Most existing studies treat ICU nurses as a homogeneous group, overlooking within-group heterogeneity. Based on the Job Demands-Resources model, this stu...

Multimodal nanomedicine for precision colorectal cancer management: integrated diagnosis, targeted therapy, and personalized theranostics

Colorectal cancer (CRC) imposes a substantial health burden because of its high incidence and mortality. Despite advances in surgical procedures, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the overall efficacy is still unsatisfactory, especially for advanced...

Exploratory analysis of the impact of age stratification on outcomes of combined Salter osteotomy and femoral osteotomy in pediatric developmental dysplasia of the hip using a 3-year cutoff

Abstract Objective This study compared outcomes of combined Salter osteotomy, open reduction, and proximal femoral osteotomy in developmental dysplasia of the hip (DDH) children under 3 years versus those aged 3 years or older. Methods This retrospective study analyzed 65 DDH pat...

A pilot prospective study of tislelizumab and axitinib combined with stereotactic body radiation therapy for oligometastatic renal cell carcinoma

<title>Abstract</title> Background The aim of this study is to investigate the efficacy and safety of tislelizumab and axitinib combined with SBRT in the treatment of omRCC. Methods Eligible pts had oligometastases (≤ 5 leisions) and ≤ 1 prior systemic therapy. All patients recei...

Feasibility analysis of negative pressure wound therapy for odontogenic ascending necrotizing fasciitis: a single-center single-arm retrospective case series

Abstract Background Odontogenic ascending necrotizing fasciitis (ANF) is an extremely rare, rapidly progressive, and destructive craniomaxillofacial necrotizing soft tissue infection. Advanced surgical drainage is essential to improve cure rates, shorten the disease course, and a...

Repetitive transcranial magnetic stimulation normalizes cerebrocerebellar loop functional connectivity in spinocerebellar ataxia type 3

Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disorder characterized by ataxia; structural and functional damage to the cerebrocerebellar loop play key roles in its pathology. However, effective treatments for SCA3 remain limited. Repetitive...

The impact of preoperative radiological paraspinal lumbar measures on the postoperative satisfaction of patients following lumbar fusion surgery– a retrospective case-control study

Paraspinal muscles have been reported to associated with postoperative outcomes in patients undergoing lumbar spine surgery. This study aimed to determine whether preoperative radiological measures of lumbar paraspinal muscles could predict postoperative patient satisfaction. A t...

Development of a nomogram for predicting extramural venous invasion in colon cancer using spectral CT multiparameter imaging

Abstract Purpose To develop a predictive model based on spectral CT-derived parameters for preoperative assessment of extramural venous invasion (EMVI) in patients with colon cancer. Methods This retrospective study included 235 patients with pathologically confirmed colon cancer...

Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial

Background Sex-based differences in treatment response to neuroprotective strategies during endovascular treatment (EVT) for acute ischemic stroke remain poorly understood. Objectives This study aimed to evaluate sex-specific effects of methylprednisolone on outcomes after EVT fo...

Machine learning–guided identification of determinants of PD-L1 expression and tumor mutational burden in lung squamous cell carcinoma

Programmed death-ligand 1 (PD-L1) expression and tumor mutational burden (TMB) are widely used immunotherapy biomarkers, yet their variability and determinants in lung squamous cell carcinoma (LUSC) remain incompletely characterized in real-world testing settings. We analyzed a r...