Peking University Cancer Hospital

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with gemcitabine resistance remaining a major clinical challenge. Although cancer stemness and autophagy have both been implicated in PDAC chemoresistance, the mechanism by which their crosst...

Peripheral CD4 + T‐Cell Reserve as a Potential Biomarker of CD20 × CD3 Bispecific Antibody Outcomes and BTK Inhibitor–Associated Immune Modulation in B‐Cell Lymphoma

ABSTRACT Bispecific antibodies (BsAbs) targeting CD20 × CD3 have achieved remarkable efficacy in relapsed or refractory (R/R) B‐cell lymphoma, yet clinical responses remain heterogeneous and predictive biomarkers are lacking. We retrospectively evaluated associations between peri...

Preclinical Evaluation of 89Zr-Labeled Anti-Nectin-4 Antibody for Enhanced PET Imaging in Bladder Urothelial Carcinoma

Abstract This study evaluated the preclinical performance of a novel 89Zr-labeled anti-Nectin-4 monoclonal antibody, [89Zr]Zr-DFO-MW282, for PET imaging of bladder urothelial carcinoma (BUC). [89Zr]Zr-DFO-MW282 was prepared via p-isothiocyanatobenzyl-desferrioxamine (p-NCS-Bn-DFO...

Comprehensive role of fluorine-18-labeled fluorodeoxyglucose PET/computed tomography across the disease course of primary malignant melanoma of the esophagus

This study aimed to evaluate the clinical value of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) in managing primary malignant melanoma of the esophagus (PMME). Seventy patients with pathologically confirmed PMME between September 2011 and June 202...

Disitamab vedotin triggers ferroptosis to activate CD8+ T-cell antitumor immunity in HER2-expressing breast cancer

Abstract Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is highly aggressive and is associated with poor prognosis after metastasis or recurrence. The development of anti-HER2 antibody–drug conjugates (ADCs) has markedly improved outcomes. Disitamab vedoti...

Molecular Machine‐Driven Fluorogenic Probes for Motion–Signal Conversion and Hydrophilicity Retention in Live‐Cell Nanoscopy

ABSTRACT Traditional fluorogenic and cell‐permeable molecular probes for live‐cell nanoscopy mainly rely on structural or hydrophilicity changes to generate intracellular fluorescence signals. Here, we introduce molecular machines into fluorogenic probe design. As a proof of conc...

Current and future burden of gastric cancer: an analysis based on CDC WONDER and the global cancer observatory

Gastric cancer remains a major contributor to the global cancer burden, with marked geographic disparities and a substantial contribution from population ageing. We aimed to integrate recent mortality trends in the United States with the latest global burden estimates to provide...

Noncanonical function of Claudin-1 mitigates lethal endoplasmic reticulum stress to drive prostate cancer lineage plasticity and chemoresistance

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mech...

Water hardness and all-cause and cause-specific mortality: evidence from a prospective cohort study

The health implications of domestic water hardness remain controversial, with limited prospective evidence on cause-specific mortality. We investigated associations of calcium carbonate (CaCO 3 ), calcium (Ca), and magnesium (Mg) concentrations with all-cause and cause-specific m...

Drugging the “undruggable” p53: a structure-guided strategy against the Y220C mutation

Abstract Tumor Protein p53 (TP53 ) is the most frequently altered gene in human cancer, yet mutant p53 has long been considered undruggable. The Y220C mutation is exceptional because it both destabilizes the p53 DNA-binding domain (DBD) and creates a unique surface pocket absent...

Efficacy and Safety of DVDMS ‐Photodynamic Therapy for Dysphagia in Advanced Esophageal Cancer: A Phase II Clinical Trial

ABSTRACT Photodynamic therapy (PDT) is a localized treatment for esophageal stenosis and dysphagia in advanced cancer. This study evaluated the efficacy and safety of Cosiporfin sodium (DVDMS)‐mediated PDT for dysphagia in advanced esophageal cancer. In this Phase II trial, patie...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Extracellular vesicle proteins monitor and interfere with CLDN18.2-targeted CAR-T cell and antibody therapies against gastrointestinal cancers

Abstract Claudin 18.2 (CLDN18.2)-targeted CAR-T cell and antibody therapies show promise against gastrointestinal cancers, but biomarkers predictive of long-term benefit and therapeutic sensitization strategies are needed. Here we show that proteins carried by circulating extrace...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Nintedanib in the prevention of radiation-induced lung injury in patients with unresectable stage II-III NSCLC: A protocol for a randomized, multicenter, control group study

Background Radiation-induced lung injury (RILI) is a common and dose-limiting complication in patients with non-small cell lung cancer (NSCLC) receiving radiotherapy, especially in combination with chemotherapy and/or immunotherapy. RILI encompasses acute radiation pneumonitis (R...

Synergistic antitumor immune activation in melanoma using LA-PegPI polymeric gene vaccine in conjunction with PD-1 inhibition

Cancer gene vaccines are a promising avenue for cancer immunotherapy; however, their success depends not only on the gene construct itself but more critically on the efficacy and safety of the gene delivery vehicle. Targeting dendritic cells (DCs), the specialized antigen-present...

Autophagy-regulating bioactive nanoparticle alleviates MASH via gut–liver axis-mediated mitochondria/cAMP/GLP1 pathway

Chronic exposure of the liver to diverse insults can lead to metabolic dysfunction-associated steatohepatitis (MASH), a complex metabolic disorder characterized by hepatic steatosis and inflammation, often accompanied by progressive fibrosis, intestinal barrier dysfunction, and i...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Longitudinal metagenomic profiling of gut microbiome dynamics in B-cell lymphoma patients receiving CAR-T cell therapy

Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes in B-cell malignancies, but treatment response and immune-related toxicities remain heterogeneous. We characterized peri-infusion gut microbiome dynamics and examined their associations with subsequent respons...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...