Palo Alto University

Designing Social Media Health Warnings for Teenagers and Young Adults

Importance Social media use is nearly ubiquitous among US teenagers and young adults and has been associated with increased risk for negative health outcomes such as depression and anxiety. Policymakers in several states have proposed or adopted policies requiring warnings on soc...

Threatened Identity: Self Psychology Informed Communication for Serious Illness Care

Serious illness threatens both the body and the self: the coherent, continuous sense of who one is, from bodily integrity to psychosocial identity. When illness disrupts identity and patients confront mortality and dependence, a range of responses may follow, including behaviors...

Invariant splitting principles for the Lipshitz–Ozsváth–Thurston correspondence

Abstract We prove that the Lipshitz–Ozsváth–Thurston correspondence between extended type D structures of knot complements and knot Floer complexes can be arranged so that ‐invariant splittings of knot Floer chain complexes correspond to ‐invariant splittings of bordered Floer ho...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Testing the use of local large language models to extract trauma identification and contextualize posttraumatic stress symptoms from self-report

Abstract Accurate contextualization of trauma is critical for assessing posttraumatic stress disorder (PTSD) in behavioral health contexts, yet standard self-reports often fail to link symptoms to specific index traumas. This study evaluated the feasibility of using a local, priv...

Assessing physical activity and sleep patterns in glaucoma using wearable devices

Background/aims Glaucoma has been linked to reduced physical activity and disturbed sleep, but large-scale studies using objective wearable data are scarce. We compared activity and sleep metrics between adults with and without glaucoma using commercial wrist-worn devices. Method...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

Ancestry and Kawasaki Disease: Clinical Pathway Considerations

Kawasaki disease (KD) is the leading cause of pediatric acquired heart disease in developed countries.1 Despite decades of research, no established biologic marker has been identified, and KD remains a clinical diagnosis.1,2 However, KD research has shown that different populatio...

Early life exposures association with later diagnosis of spondyloarthritis: A population-based case-control study

Objective To assess whether early-life antibiotics are associated with spondyloarthritis (SpA) diagnosed by age 21. Methods In this population-based, matched case–control study, we used Danish live births (1997-2023) restricted to those reaching minimum relevant ages by December...

Bias in Cohort Studies: The Critical Importance of the “Why” and “When” of Treatment Decisions

When it comes to high-quality, rigorous research, children generally get the short end of the stick. Randomized controlled trials (RCTs)—the “gold standard” for clinical research1—are rare in this population.2 RCTs are expensive, time-consuming, and often fraught with ethical con...

Price comparisons for the leading brands of oral nicotine pouches and cigarettes

Abstract Background and aims United States (US) sales of oral nicotine pouches (ONPs) more than tripled from 2021 to 2024, with Zyn brand consistently the market leader. To understand the relative price of ONPs and cigarettes, this study answers three questions about differences...

Watson's Caring Science-Based Interventions in Holistic Nursing and Health Care: A Scoping Review of Patient Satisfaction and Clinical Outcomes

PurposeTo map and summarize the literature on Watson's Caring Science Theory-based interventions in relation to patient satisfaction and clinical outcomes. Watson's Caring Science Theory provides a foundational framework for relational and holistic nursing care, yet evidence on p...

Resident Perspectives on Post-Rounds Communication With Families Using Diverse Languages

OBJECTIVE To explore pediatric residents’ experiences communicating with families after rounds and identify barriers and facilitators to communication with families using languages other than English (LOE). METHODS We conducted a qualitative study using semi-structured interviews...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...

Real-world use of large language models for mental health in 2024

The extent to which people use general-purpose large language models (LLMs) for their mental health is unknown. Information about use patterns is important for clinicians, developers, and regulators. We surveyed U.S. adults ( n = 1871) between August and October 2024 using strati...