Oxford University Clinical Research Unit Nepal

Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation

Background The effect of timely appropriate antibiotics in multidrug-resistant Gram-negative bacteria (MDR-GNB) bloodstream infections (BSIs) remains uncertain. Robust evidence is needed to inform diagnostic and treatment strategies, especially across settings with high antimicro...

Exploring factors contributing to inappropriate use of antibiotics for common childhood illnesses among parents in Nepal: a qualitative study

Abstract Background Inappropriate antibiotic use contributes to antimicrobial resistance (AMR) and is particularly concerning in children, who frequently experience common infections. Evidence on how parents use antibiotics for common childhood illnesses in Nepal is limited. This...

Persistence of immune responses 5 years after vaccination with a single dose of typhoid conjugate vaccine (TCV) in Nepalese children

Background A single-dose typhoid conjugate vaccine (TCV) has been recommended in endemic settings. Here we report the 5-year immunogenicity results post a single dose of TCV in Nepal. Methods We conducted a participant- and observer-blinded randomised trial (RCT) in Lalitpur, Nep...