Novo Nordisk (Denmark)

High sensitivity C-reactive protein and the risk of cardio-kidney outcomes in adults with moderate to severe chronic kidney disease: a nationwide study

BACKGROUND AND HYPOTHESIS: The burden and prognostic significance of inflammation in chronic kidney disease (CKD) remains poorly characterized, with prior studies yielding conflicting estimates of the association between elevated high-sensitivity C-reactive protein (hsCRP) and ca...

Engineering and Kinetic Profiling of a Thrombin-Activable Prodrug Antibody Targeting P-Selectin.

Antibody prodrugs represent a promising therapeutic format that provides advantages compared to conventional monoclonal antibody therapeutics. In this study, we engineered an antibody prodrug using an anti-P-selectin antibody as a model system, incorporating N-terminal heavy chai...

Efficient sampling of liver tissue for histological analysis of rodent MASLD/MASH models.

Mouse and rat models of MASLD/MASH can provide valuable information about the effects of potential new treatments on liver histopathology. Liver samples for histology must therefore be representative of the entire organ, but it is also important that they can be collected efficie...

Machine Learning-Guided Discovery of Robust Conditions for Photochemical Nickel-Catalyzed Cysteine Arylation

Abstract Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional...

Real-world cardiovascular effects of liraglutide: transportability analysis of the LEADER trial

Abstract Appropriate use of recently approved type 2 diabetes treatments depends on external validity of landmark clinical trials (RCTs) in real-world populations that may differ from trial participants. This study transported effect estimates from the Liraglutide Effect and Acti...

Effect of Semaglutide on Thigh Skeletal Muscle Volume, Fat Infiltration and Physical Function in People With Obesity: Secondary Analysis of STEP UP

ABSTRACT Aims To assess the effect of semaglutide on body composition and physical function. Materials and Methods The phase 3b STEP UP trial randomised adults with body mass index ≥ 30 kg/m 2 to once‐weekly subcutaneous semaglutide 7.2 mg, semaglutide 2.4 mg or placebo for 72 we...

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

AIM: Oxytocin has been proposed to exert glucose-stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin d...

Single-cell profiling identifies obesity-disrupted brain glucose sensing

Abstract Neuronal nutrient sensing in the hypothalamus and brainstem is thought to regulate energy and glucose homeostasis, yet how these brain regions respond to elevated adiposity or blood glucose remains unclear. We performed single-nucleus RNA-sequencing on 75,787 cells from...

The effect of telemonitoring on quality of life in people with insulin‐treated type 2 diabetes: A secondary analysis of a randomised controlled trial

Abstract Aims Telemonitoring in type 2 diabetes (T2D) care has demonstrated positive trends in terms of glycaemic control. However, evidence regarding its impact on patient‐reported outcomes, such as general and diabetes‐specific quality of life (QoL), remains inconclusive. In pa...

Glucose in Motion: Characterizing Temporal Patterns in Real-World Glycemic Control in a Large Observational Cohort

OBJECTIVE: To identify and characterize daily and weekly patterns in glycemic management in longitudinal real-world continuous glucose monitoring (CGM) data from people with diabetes to enhance clinical interpretation and support more effective personalized diabetes management. R...

Quantifying the fiscal benefits of obesity prevalence reduction in China

With obesity becoming increasingly prevalent in China, its impact extends beyond health losses to wider public finance pressures. This study assessed the fiscal implications of reducing obesity prevalence from the government perspective and explored the potential fiscal benefits...