Northwestern University

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Revealing the Proton Slingshot Mechanism in Solid Acid Electrolytes through Machine-Learning Molecular Dynamics

Abstract In solid acid electrolytes CsH2PO4 and CsHSO4, the origin of fast proton conduction has long been debated, attributed either to local proton hopping or to polyanion rotation. However, the precise role of polyanion rotation and its interplay with proton hopping remains un...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Metformin Spacer Conformation Is a Structure-Directing Element in a 2D Perovskite with Strong X-ray Response

Abstract Direct X-ray detection in two-dimensional (2D) hybrid metal-halide perovskites is dictated by the interplay between organic spacer chemistry, crystal structure, and charge transport. Among these materials, the metformin (MF2+)-based perovskite MFPbI4 has recently emerged...

Oxide-Nitride Heteroepitaxy for Low-Loss Dielectrics in Superconducting Quantum Circuits

Abstract Superconducting qubits show great promise for the realization of fault-tolerant quantum computing, but lossy, amorphous dielectrics limit current technology. Identifying highly crystalline and stoichiometric dielectrics with intrinsically low microwave loss is therefore...

A compact, wireless fluorimeter system for continuous, real-time monitoring of tissue perfusion via in vivo fluorescence signals

In vivo fluorescence signals provide physiological and pathological insights for the interpretation of biological states associated with anatomical abnormalities or disease. Conventional methods for measuring fluorescence signals rely on bulky, costly instrumentation for imaging...

Geometry-engineered ion transport enables over 4000-h salt-free solar evaporation using Janus electrospun membranes

Abstract Salt accumulation and surface fouling remain major barriers to long-term solar-driven interfacial evaporation. Here we report a geometry-engineered Janus electrospun membrane that integrates asymmetric wetting with structural design to suppress salt buildup. The membrane...

Engineered Orthogonal Translation Systems from Metagenomic Libraries Expand the Genetic Code

Abstract Genetic code expansion with noncanonical amino acids (ncAAs) opens new opportunities for the design and engineering of proteins by broadening their chemical repertoire. Unfortunately, ncAA incorporation into proteins is limited both by a small collection of orthogonal am...

EPR and ENDOR Characterization of Fe- and S-Ethylated [4Fe-4S]1+ Clusters, and a Cascade of H-Atom Abstractions Following Photolysis of the Fe–C Bond

Abstract Initiation of radical reactions by radical S-adenosyl-l-methionine (SAM) enzymes involves a central organometallic intermediate denoted Ω, with an Fe–C bond between the unique iron of a [4Fe-4S]3+ cluster and 5′C of 5′-dAdo. In some radical SAM (RS) enzyme processes, the...

Why translation is not enough and how functional language use can improve cultural adaptation in bilingual implementation settings

Despite widespread bilingualism, most intervention adaptation efforts remain grounded in monolingual assumptions. This approach poorly reflects how bilingual communication functions. Research in sociolinguistics and psycholinguistics shows that bilingual speakers do not “turn off...

Exploiting Acquired Drug Resistance in Pancreatic Cancer through Selective Covalent Targeting of MAP2K4/7

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and remains largely refractory to targeted therapy despite its near-universal dependence on oncogenic KRAS. Single-agent KRAS inhibitors often fail due to adaptive resistance mechanisms that emerge under pharmacologic press...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

An Experience-Sampling Approach to Examining Cortisol and Testosterone Profiles in Bipolar and Depressive Mood Disorders

Emotion dysregulation is a core component of bipolar disorder (BD). However, there is a critical gap concerning the measurement of emotion-relevant neuroendocrine processes in this population. The present investigation examined neuroendocrine profiles (i.e., cortisol and testoste...

Evaluating Rate and Time Effects on Cyclically Loaded Offshore Foundations via a Bounding-Surface Viscoplastic Model

Abstract Offshore foundations are subjected to cyclic loading from waves, winds, and operations, and their response is inherently time-dependent and strongly influenced by loading rates due to the viscosity of clays. This study develops a simple yet theoretically robust framework...

The animation of the opposite of finite sets

We give a direct proof of the fact that the animation of the category Finop is a 1-category. This article is part of the theme issue 'Derived Lie algebras in geometry and topology'.

Reconceptualizing Cerebral Palsy as a Lifelong Condition Characterized by Systemic and Accelerated Biological Decline

Cerebral palsy (CP), the most common childhood-onset disability worldwide, affects an estimated 50 million individuals globally. Although most individuals with CP are adults, CP education and training remain heavily concentrated within pediatric subspecialties, contributing to su...

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer

Background: Small-cell lung cancer (SCLC) is characterized by pervasive chromosomal instability (CIN) and remains largely refractory to targeted therapies. KIF18A, a motor protein that regulates chromosome alignment during mitosis, has emerged as a selective dependency in CIN-hig...

A memorial tribute to Dr. Asgerally T. Fazleabas

Gregory W Burns, Yong Song, J Julie Kim; A memorial tribute to Dr. Asgerally T. Fazleabas, Biology of Reproduction, , ioag180, https://doi.org/10.1093/biol

Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults

BACKGROUND: Whether isolated diastolic hypertension (IDH) in young adults represents a benign, age-specific phenotype or confers increased cardiovascular disease risk remains uncertain. We assessed the associations between hypertension subtypes, IDH, isolated systolic hypertensio...