North Sichuan Medical University

Research trends and hotspots in colorectal cancer screening

Background: Colorectal cancer (CRC), is a highly prevalent malignant tumor worldwide, and early screening is key to improving its prognosis. Currently, CRC screening research is growing exponentially, but its core research hotspots, evolutionary trends, and interdisciplinary feat...

Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma

Acrylamide is a potential carcinogen widely encountered in occupational settings and heat-processed foods. However, the potential molecular relationships between acrylamide-associated targets and clear cell renal cell carcinoma remain poorly characterized. The toxicological chara...

Organelle contact sites as intracellular communication hubs linking metabolic stress to inflammatory disease

Abstract Membrane contact sites (MCSs) are specialized, non-fusogenic interfaces that allow organelles to exchange ions, lipids, metabolites and stress signals. These contacts support adaptation to nutrient, proteotoxic and inflammatory stress. However, persistent or misregulated...

Differential associations of aging attitude risk with depression, anxiety, and suicide-related risk among older Chinese adults: a network analysis and GGMNIRA-based simulated intervention study

Attitudes toward aging reflect how individuals understand and appraise their own aging process and may be closely associated with mental health in later life. Previous studies have primarily examined associations of attitudes toward aging with depression, anxiety, and suicide-rel...

A randomized controlled trial of internet-based cognitive behavioral therapy for sleep disturbances in ICU survivors

Objective To investigate the efficacy of Internet-based Cognitive Behavioral Therapy (ICBT) for sleep disturbances in patients discharged from the Intensive Care Unit (ICU). Methods A prospective, randomized controlled study was conducted, enrolling 120 patients with sleep distur...

A retrospective cohort study of the association between triglyceride-glucose index and its derived indicators and all-cause mortality among community-dwelling adults with a history of stroke

Abstract Objective As a novel marker of insulin resistance, the triglyceride-glucose (TyG) index has been documented to correlate with mortality in coronary artery disease and heart failure. In recent years, growing attention has been paid to the relationship between the TyG inde...

Association between ticagrelor loading timing within the primary PCI workflow and ST-segment resolution in STEMI: a single-center real-world cohort study

We examined whether the timing of ticagrelor loading relative to culprit-lesion wire crossing within the primary PCI workflow was associated with ST-segment resolution (STR) after STEMI. The loading-to-wire-crossing interval was treated as a workflow-related timing measure rather...

Sandwich structured Ω-shaped fiber optic-based sensor with dual signals for simultaneous temperature and refractive index detection

Measurements of refractive index (RI) and temperature play a vital role in a wide range of applications. Nevertheless, cross-sensitivity remains a major obstacle when RI and temperature need to be measured simultaneously. In this study, a novel sandwich structured Ω-shaped fiber...

Slogan handwritten effect: How fonts of environmental slogan affect tourists’ garbage sorting intention

Previous studies have found that text content in handwritten fonts affects individual behavior. However, the role played by handwritten font of environmental slogans in scenic spots on the tourists’ garbage sorting intention is not clear. From the perspective of social informatio...

Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes

Senescence-associated secretory phenotype (SASP)-related inflammatory programs have been implicated in type 2 diabetes mellitus (T2DM), yet blood-based candidates have not been systematically screened and validated across independent cohorts. We adopted standardized senescence si...

Limited L1 transfer and efficiency-driven strategies in L2 syntax–semantics processing: An ERP study

Cross-linguistic transfer accounts predict that second language (L2) learners benefit from structural overlap between their native language (L1) and L2, while the accessibility–complexity–efficiency model proposes that L2 learners rely on accessible cues to maintain efficiency wh...

AI-assisted age estimation from first molars: an integrated evaluation of regression, machine learning, and 1D-CNN models using CBCT-derived pulp-dentin index

Abstract Background Accurate age estimation is crucial for forensic identification, and teeth serve as durable biological markers due to their post-mortem stability. While cone-beam computed tomography (CBCT) enables precise three-dimensional assessment of age-related pulp change...

Circulating and intraplaque interleukin-40 is associated with CTA-defined high-risk carotid plaques: an integrated imaging, serological, and histopathological study

Risk assessment of carotid atherosclerosis is moving beyond stenosis-based evaluation toward the identification of biologically active plaque phenotypes. Although CTA can characterize high-risk plaque morphology, biomarkers that reflect the inflammatory processes underlying these...

Molecular engineering of peptide-drug conjugates: strategies for enhancing precision oncology

Malignant neoplasms remain a formidable challenge to global public health, representing the second leading cause of mortality worldwide. While conventional small-molecule chemotherapeutics have historically served as a cornerstone of clinical oncology, their clinical utility is s...

EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect

ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migrati...

Glycolipid metabolic crosstalk in tumor immune evasion and therapeutic targeting

Tumor immune evasion remains a major barrier to effective cancer immunotherapy and is closely associated with metabolic reprogramming. Glucose and lipid metabolism are highly interconnected processes that cooperatively reshape the tumor microenvironment (TME), regulate immune-cel...

SGLT2 inhibitors for heart failure outcomes across baseline glycemic status: a systematic review and stratified meta-analysis of independent parent trial populations

Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve heart failure outcomes, but whether relative effects are consistent across normoglycemia, prediabetes, and diabetes/type 2 diabetes remains uncertain. Linked publications from the same randomized populations may also be do...

New-onset and persistent suicidal ideation and non-suicidal self-injury among Chinese university students: A one-year longitudinal study

Suicidal ideation (SI) and non-suicidal self-injury (NSSI) are clinically important mental health concerns among university students, yet longitudinal evidence distinguishing new-onset and persistent patterns remains limited. This one-year longitudinal study examined changes in S...

Integrative genomic dissection of cardio-kidney-metabolic syndrome reveals novel loci, causal genes, and tissue-specific pathways in European populations

Cardiovascular-kidney-metabolic (CKM) syndrome has placed a substantial burden on society both socially and economically. But currently, little is known about the genetic structure of CKM syndrome. A multivariate genome-wide association study (GWAS) of CKM syndrome (mvCKM) in Eur...

Trends in Smoking-Attributable Disease Burden in China, 1990–2021: Age, Sex, and Risk Factors in a Global Context

INTRODUCTION: Smoking remains one of the leading preventable causes of morbidity and mortality worldwide. Understanding long-term trends in smoking-related diseases is essential for evaluating policy effectiveness and guiding prevention efforts. This study assessed the burden of...