Normandie Université

Profiles of Post-traumatic Symptoms and Well-Being Among Young Adults: Associations With Early Adversity, Psychopathology and Social Support

Post-traumatic stress symptoms (PTSS) are common in young adulthood, yet symptom-based approaches provide only a partial account of mental health. The dualcontinua model conceptualizes mental health as the coexistence of psychological distress and psychological well-being (PWB),...

Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models

Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...

Monitoring symptoms and performance in rehabilitation: Can we detect COPD exacerbation?

Background In patients with COPD, exacerbations mark disease progression, with significant reduction in quality of life and impact on mortality. Early detection is crucial to mitigate their consequences. The aim of this study was to investigate whether monitoring symptoms and exe...

Approximation of adelic divisors and equidistribution of small points

Abstract We study the asymptotic distribution of the Galois orbits of generic sequences of algebraic points of small height in a projective variety over a number field. Our main result is a generalization of Yuan’s equidistribution theorem that applies to heights for which Zhang’...

Perceptual-motor processes in cycling: A scoping review

Cycling is increasingly recognized as a sustainable and efficient mode of transport, demanding a high level of perceptual-motor coordination for safety and performance. Despite extensive research on biomechanics and physiological capacities in cycling, perceptual-motor dynamics –...

Pain Management in Older Adults: An Interprofessional Training Approach Assessed by Script Concordance Tests

ABSTRACT Background Optimal perioperative pain management in older adults challenges anesthesiologists due to increased drug sensitivity, altered pharmacokinetics, and limitations of pain assessment tools in cognitively impaired patients. This study evaluated whether a single 60‐...

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

SENIOR ‐ IPI : An easily applicable prognostic index for first‐line large B‐cell lymphomas patients >80 years treated with curative intent

Summary Using LYmphoma Study Association clinical trials combining 438 first‐line large B‐cell lymphomas (LBCL) patients >80 years old, we defined SENIOR‐IPI, an easily applicable prognostic index for this elderly population treated with an anti‐CD20‐miniCHOP (cyclophosphamide, d...

Hydroalkylation and hydroacylation of trifluoromethyl olefins by N-centered direct hydrogen atom transfer photocatalysis

The selective functionalization of trifluoromethyl olefins, while keeping the essential trifluoroalkyl moiety intact, remains a synthetic challenge. In this study, we report the use of an acridinium amidate as a direct hydrogen atom transfer (d-HAT) photocatalyst for the mild and...

Design of Potent, Non-Toxic Antimicrobial Agents Derived from the Frog Skin Peptide Raniseptin-PL Active Against Gram-Negative ESKAPE+ Pathogens

Background/Objectives: The frog skin peptide raniseptin-PL (GVFDTVKKIGKAVGKFALGVAKNYLNS.NH2) is active against a range of antibiotic-resistant bacteria including ESKAPE+ pathogens, but its therapeutic potential is limited by high cytotoxicity against mammalian cells. The study ai...

Evolution of the Involvement of Researchers From the University of Caen (France) in Author Identifiers and Social Networks: 2019–2023

ABSTRACT As author identifier services (AIDs) and academic social networks (ASNs) have become increasingly central to scholarly communication in the last decade, it is important to study how these tools are being used and how far researchers are involved in these services. This s...

The Chornobyl Dogs: Why Scientific Evaluation Must Accompany Population Management

Nearly four decades after the 1986 reactor explosion, several hundred semi-feral dogs persist within the Chornobyl Exclusion Zone. Genomic work has characterised their population structure and shown that radiation-induced mutation does not, on current evidence, drive the differen...

Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model

Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of this study was to...

Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice

Microglia closely associate with the vasculature, but their roles in leukocyte trafficking and cerebral blood flow (CBF) during systemic inflammation are unclear. We show that sustained systemic inflammation leads to altered microglia-vascular interactions, leukocyte recruitment...

Multiscale Symmetry Breaking Enables Tunable Magnetic Anisotropy and Damping in Co 2 FeAl Thin Films

ABSTRACT The ability to simultaneously engineer magnetic stability and spin dissipation remains difficult to realize in scalable metallic thin films. Here, we show that multiscale symmetry breaking provides a route to achieve this control in polycrystalline Co 2 FeAl films withou...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

Exploring the spatial distribution of biomolecules in Pseudomonas aeruginosa biofilms formed on PDMS and lung explants by mass spectrometry imaging

Bacterial biofilms constitute a form of collective organization that enhances bacterial tolerance to both antibiotics and immune defences. Among bacteria, Pseudomonas aeruginosa (P. aeruginosa) is a major opportunistic pathogen, with marked biofilm-forming capacity, highly implic...

Identification of a Point Source in the Heat Equation from Sparse Boundary Measurements

Abstract. In this work we investigate the inverse problem of recovering one point source in the heat equation from sparse boundary measurement, i.e., the flux data at several points on the boundary. We prove the unique recovery of the location and piecewise constant in time ampli...

In-host adaptation of Staphylococcus aureus during recurrent prosthetic joint infections: a retrospective longitudinal study

ABSTRACT The aim of this study was to characterize the in vivo evolution of Staphylococcus aureus strains involved in recurrent prosthetic joint infections (PJIs) both phenotypically and genomically. We conducted a monocentric retrospective study in a 1,437-bed French teaching ho...

Efficient power generation near room temperature in earth-abundant thermoelectric tin sulfide via lattice ordering

The inefficient carrier transport of earth-abundant tin sulfide (SnS), arising from its intrinsically low crystal symmetry, limits its thermoelectric performance at low temperatures. Here, the substitutional Ag+ doping modifies the Na-doped SnS crystal structure by reinforcing la...