Newcastle upon Tyne Hospitals NHS Foundation Trust

‘People need to be a bit more understanding that my body is wrecked’: A qualitative exploration of inpatient hospital care for people living with multiple long-term conditions

BACKGROUND: Living with multiple long-term conditions (MLTC) is becoming increasingly common with far-reaching consequences for individuals and healthcare systems. People with MLTC often face complex care pathways through health systems - especially hospitals, which are largely c...

Long-term outcomes of indeterminate breast (B3) lesions managed with vacuum-assisted excision

Abstract Background UK guidelines for indeterminate (B3) breast lesions recommend vacuum-assisted excision (VAE) over diagnostic surgery. However, there is little long-term follow-up published post VAE management. This study evaluates immediate and long-term outcomes of women wit...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

A global study of novel agents in paediatric and adolescent relapsed and refractory B-cell non-Hodgkin lymphoma (Glo-BNHL): protocol for an adaptive international platform clinical trial

The second Paediatric Strategy Forum of the international multi-stakeholder organisation, ACCELERATE (Nov-2017), concluded that an international approach to conducting clinical trials in relapsed and refractory paediatric B-cell non-Hodgkin lymphoma (r/r B-NHL) was critical and t...

Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics

Abstract The meninges are increasingly recognized as key stromal and immune niches supporting cranial development. Here we constructed a paired single-nuclei RNA and Assay for Transposase-Accessible Chromatin atlas of human meningeal development from 6 to 21 postconception weeks...

A qualitative exploration of information access and provision for cancer survivors experiencing chronic bowel symptoms after pelvic radiotherapy: informing a framework to guide improvements to information provision

Abstract Purpose For people living with and beyond cancer, access to clear, accurate, relevant information is crucial for meaningful participation in shared decision-making and is associated with better quality-of-life. Many cancer patients who undergo pelvic radiation experience...

High-resolution Manometry Catheter Insertion During Sedated Endoscopy; A Viable Option When Standard Intubation Fails

Background/Aims: : When high-resolution manometry (HRM) intubation is not tolerated or the catheter fails to traverse the lower esophageal sphincter, the test is often abandoned, leaving patients without a diagnosis to guide therapy. Although endoscopic placement of HRM catheters...

Understanding the impact of Multiple Long-Term Conditions (MLTC) on the completion of delirium screening documentation: analysis using routinely collected clinical data

Abstract Introduction Multiple Long-Term Conditions (MLTC) are a recognised risk factor for delirium, but little is known about the impact of MLTC on delirium screening. This study aimed to explore the impact of MLTC on delirium screening documentation for older, hospitalised peo...

Development and evaluation of a dental nurse-led acupuncture service for myogenous temporomandibular disorder

Aims Acupuncture is an established treatment for myogenous temporomandibular disorder (mTMD). Long waiting times and limited outcome recording highlighted service improvement need. A dental nurse-led acupuncture clinic was introduced to increase access and improve clinical outcom...

Macular neovascularisation subtype determines visual consequences of early fibro-atrophic remodelling in neovascular AMD: PRECISE study report 11

Abstract Purpose To evaluate whether baseline well-delineated hyperreflective material (wdHRM) is associated with short-term visual outcome in treatment-naïve neovascular age-related macular degeneration (nAMD), whether this association differs by macular neovascularisation (MNV)...

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

From questions to impact in spinal muscular atrophy - identifying community-driven research priorities through a multi-stakeholder European initiative

Abstract Background Advances in medicines have transformed the outlook for people living with spinal muscular atrophy (SMA), yet many needs remain unmet. As the scientific and clinical environment evolves, aligning research priorities with the lived experience of patients is incr...

Uncommon benign tumour of the scalp

A 37-year-old male (Fitzpatrick skin type III) presented with a 10-month history of an enlarging nodule on the right parietal scalp. There was a paternal history of melanoma, but no family history of similar skin lesions. Physical examination revealed an ill-defined, pink, round,...

Digital learning to support recruitment into cancer clinical research nursing: evaluation of a national e-learning course

Clinical research nurses (CRNs) are essential to the safe delivery of cancer clinical trials and represent an important component of the specialist cancer nursing workforce. However, nursing students often have limited awareness of the role and may not recognise it as a potential...

Digenic disease causing variants in a patient with severe nephrocalcinosis

Abstract Background Nephrocalcinosis and cystinuria are two distinct kidney disorders. Nephrocalcinosis is the abnormal, generalised deposition of calcium salts, primarily calcium phosphate or calcium oxalate, within the kidney's parenchyma, and has multiple causes including meta...

The diagnosis and management of primary mediastinal B‐cell lymphoma: A British Society for Haematology guideline

Summary Primary mediastinal B‐cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B‐cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematolog...

P1.125. Challenging a Histology-Led Paradigm: Comparable Real-World Survival After Definitive Non-Surgical Treatment in Oesophageal Adenocarcinoma and Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Histology is often treated as a surrogate for radiosensitivity in oesophageal cancer, sustaining the prevailing assumption that squamous cell carcinoma (SCC) benefits more from definitive chemoradiotherapy th...

Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments

BACKGROUND: Early recognition of sepsis in emergency departments (EDs) improves outcomes and reduces healthcare resource use. However, current clinical practice (CCP), largely based on the National Early Warning Score 2 (NEWS2) and clinical judgement, has limited diagnostic sensi...

Vulnerable groups’ engagement with interventions to mitigate the health impacts of exposure to extreme temperature events: a qualitative systematic review

Abstract Extreme temperature events are becoming more frequent. Such events are defined as unusually hot weather persisting for at least two consecutive days (heatwave) or unusually cold weather persisting for at least two consecutive days (cold wave) within the context of geogra...